Proteasome-dependent processing of nuclear proteins is correlated with their subnuclear localization

Although proteasomes are abundant in the nucleoplasm little is known of proteasome-dependent proteolysis within the nucleus. Thus, we monitored the subcellular distribution of nuclear proteins in correlation with proteasomes. The proteasomal pathway clears away endogenous proteins, regulates numerou...

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Veröffentlicht in:	Journal of structural biology 2002-10, Vol.140 (1), p.189-199
Hauptverfasser:	Dino Rockel, Thomas, von Mikecz, Anna
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - analogs & derivatives Acetylcysteine - pharmacology Actins - metabolism Antigen processing Cell Nucleus - metabolism Cell Survival Cysteine Endopeptidases - metabolism Cysteine Proteinase Inhibitors - pharmacology Electrophoresis, Polyacrylamide Gel HeLa Cells Humans Immunoblotting Lactacystin Microscopy, Confocal Microscopy, Fluorescence Multienzyme Complexes - metabolism Neoplasm Proteins - metabolism Nuclear Proteins Nucleus PML Promyelocytic Leukemia Protein Proteasome Endopeptidase Complex Proteasomes Spliceosome Spliceosomes - metabolism Time Factors Transcription Factors - metabolism Tumor Suppressor Proteins
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