Proapoptotic Bax is hyperexpressed in isolated human islets compared with antiapoptotic Bcl-2

Apoptosis is a well-documented pathway for islet cell death. One potential mechanism is overexpression of death-promoting Bax compared with antiapoptotic Bcl-2 in islets. We isolated islets from 10 human pancreata and measured the expression of Bax mRNA and Bcl-2 mRNA by real-time quantitative polym...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Transplantation 2002-12, Vol.74 (11), p.1489-1496
Hauptverfasser:	THOMAS, Dolca, HUA YANG, KAPUR, Sandip, HANCOCK, Wayne W, SUTHANTHIRAN, Manikkam, BOFFA, Daniel J, RUCHUANG DING, SHARMA, Vijay K, LAGMAN, Milagros, BAOGUI LI, HERING, Bernhard, MOHANAKUMAR, Thalachallour, LAKEY, Jonathan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Apoptosis - physiology bcl-2-Associated X Protein Biological and medical sciences Cryopreservation Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Female Humans Islets of Langerhans - metabolism Islets of Langerhans - physiology Male Management. Various non-drug treatments. Langerhans islet grafts Medical sciences Middle Aged Pancreas Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - physiology Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - physiology RNA, Messenger - metabolism Time Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!