VEGF-mediated angiogenesis of human pheochromocytomas is associated to malignancy and inhibited by anti-VEGF antibodies in experimental tumors

Background. Pheochromocytomas are well-vascularized tumors of the adrenal medulla. In human pheochromocytomas, angiogenesis has been associated with tumor progression. The mechanisms, however, are unknown. Methods. Surgical specimens of benign, invasive, and metastatic human pheochromocytomas (n = 1...

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Veröffentlicht in:	Surgery 2002-12, Vol.132 (6), p.1056-1063
Hauptverfasser:	Zielke, Andreas, Middeke, Martin, Hoffmann, Sebastian, Colombo-Benkmann, Mario, Barth, Peter, Hassan, Iyad, Wunderlich, Annette, Hofbauer, Lorenz C., Duh, Quan-Yang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Gland Neoplasms - metabolism Adrenal Gland Neoplasms - therapy Animals Antibodies, Monoclonal - pharmacology Cell Division Endothelial Growth Factors - immunology Endothelial Growth Factors - metabolism Female Immunotherapy In Vitro Techniques Intercellular Signaling Peptides and Proteins - immunology Intercellular Signaling Peptides and Proteins - metabolism Lymphokines - immunology Lymphokines - metabolism Mice Mice, Inbred BALB C Mice, Nude Neoplasm Transplantation Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - therapy PC12 Cells Pheochromocytoma - metabolism Pheochromocytoma - therapy Rats Specific Pathogen-Free Organisms Transplantation, Heterologous Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors
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