Bisintercalators of DNA with a rigid linker in an extended configuration

A new class of DNA bisintercalators is reported in which phenanthridinium or acridinium rings are connected by rigid and extended linkers of varied length. Cross-linking of DNA by bisintercalation is inferred from the unwinding and folding of linear DNA induced by the compound; after ligation and re...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemistry (Easton) 1992-01, Vol.31 (3), p.842-849
Hauptverfasser:	Mullins, Stephen T, Annan, Nikoi K, Cook, Peter R, Lowe, Gordon
Format:	Artikel
Sprache:	eng
Schlagworte:	Acridines - chemical synthesis Acridines - chemistry Analytical, structural and metabolic biochemistry Biological and medical sciences DNA - chemistry Dna, deoxyribonucleoproteins Fundamental and applied biological sciences. Psychology Indicators and Reagents Intercalating Agents - chemistry Ligands Magnetic Resonance Spectroscopy Models, Structural Molecular Structure Nucleic acids Phenanthridines - chemical synthesis Phenanthridines - chemistry Plasmids Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!