Bisintercalators of DNA with a rigid linker in an extended configuration
A new class of DNA bisintercalators is reported in which phenanthridinium or acridinium rings are connected by rigid and extended linkers of varied length. Cross-linking of DNA by bisintercalation is inferred from the unwinding and folding of linear DNA induced by the compound; after ligation and re...
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| Veröffentlicht in: | Biochemistry (Easton) 1992-01, Vol.31 (3), p.842-849 |
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| container_end_page | 849 |
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| container_issue | 3 |
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| container_title | Biochemistry (Easton) |
| container_volume | 31 |
| creator | Mullins, Stephen T Annan, Nikoi K Cook, Peter R Lowe, Gordon |
| description | A new class of DNA bisintercalators is reported in which phenanthridinium or acridinium rings are connected by rigid and extended linkers of varied length. Cross-linking of DNA by bisintercalation is inferred from the unwinding and folding of linear DNA induced by the compound; after ligation and removal of the bisintercalator, superhelical circles, catenanes, and knots that bear an imprint of the bisintercalator are observed. These novel bisintercalators are of interest because they can be used to probe the organization of DNA in three-dimensional space, especially near sites of replication, recombination, or topoisomerase action, where two duplexes must be in close proximity. |
| doi_str_mv | 10.1021/bi00118a029 |
| format | Article |
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These novel bisintercalators are of interest because they can be used to probe the organization of DNA in three-dimensional space, especially near sites of replication, recombination, or topoisomerase action, where two duplexes must be in close proximity.</description><identifier>ISSN: 0006-2960</identifier><identifier>EISSN: 1520-4995</identifier><identifier>DOI: 10.1021/bi00118a029</identifier><identifier>PMID: 1731942</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Acridines - chemical synthesis ; Acridines - chemistry ; Analytical, structural and metabolic biochemistry ; Biological and medical sciences ; DNA - chemistry ; Dna, deoxyribonucleoproteins ; Fundamental and applied biological sciences. Psychology ; Indicators and Reagents ; Intercalating Agents - chemistry ; Ligands ; Magnetic Resonance Spectroscopy ; Models, Structural ; Molecular Structure ; Nucleic acids ; Phenanthridines - chemical synthesis ; Phenanthridines - chemistry ; Plasmids ; Structure-Activity Relationship</subject><ispartof>Biochemistry (Easton), 1992-01, Vol.31 (3), p.842-849</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a383t-156da6a396bb60c781a38c5e38b867b0cd12dad5ba236ac4625dcfc36b55181d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/bi00118a029$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/bi00118a029$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5109093$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1731942$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mullins, Stephen T</creatorcontrib><creatorcontrib>Annan, Nikoi K</creatorcontrib><creatorcontrib>Cook, Peter R</creatorcontrib><creatorcontrib>Lowe, Gordon</creatorcontrib><title>Bisintercalators of DNA with a rigid linker in an extended configuration</title><title>Biochemistry (Easton)</title><addtitle>Biochemistry</addtitle><description>A new class of DNA bisintercalators is reported in which phenanthridinium or acridinium rings are connected by rigid and extended linkers of varied length. Cross-linking of DNA by bisintercalation is inferred from the unwinding and folding of linear DNA induced by the compound; after ligation and removal of the bisintercalator, superhelical circles, catenanes, and knots that bear an imprint of the bisintercalator are observed. These novel bisintercalators are of interest because they can be used to probe the organization of DNA in three-dimensional space, especially near sites of replication, recombination, or topoisomerase action, where two duplexes must be in close proximity.</description><subject>Acridines - chemical synthesis</subject><subject>Acridines - chemistry</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Biological and medical sciences</subject><subject>DNA - chemistry</subject><subject>Dna, deoxyribonucleoproteins</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Indicators and Reagents</subject><subject>Intercalating Agents - chemistry</subject><subject>Ligands</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Models, Structural</subject><subject>Molecular Structure</subject><subject>Nucleic acids</subject><subject>Phenanthridines - chemical synthesis</subject><subject>Phenanthridines - chemistry</subject><subject>Plasmids</subject><subject>Structure-Activity Relationship</subject><issn>0006-2960</issn><issn>1520-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkMFPFTEQhxuDgQd68mzSA4GDWZ222-7u8YEgmhc0EYVbM9t2obCvi-1uxP_emn0BDp4mM78vv0w-Qt4weM-Asw-tB2CsRuDNC7JgkkNRNo3cIgsAUAVvFOyQ3ZRu81pCVW6TbVYJ1pR8Qc6OfPJhdNFgj-MQEx06-vF8SX_78YYijf7aW9r7cOci9YFioO5hdME6S80QOn89RRz9EF6Rlx32yb3ezD3y4_Tk4visWH399Pl4uSpQ1GIsmFQWFYpGta0CU9Us3410om5rVbVgLOMWrWyRC4WmVFxa0xmhWilZzazYIwdz730cfk0ujXrtk3F9j8ENU9IVr2pQoszguxk0cUgpuk7fR7_G-Ecz0P-86WfeMv12Uzu1a2ef2FlUzvc3OaasqosYjE-PmGTQQCMyVsyYT6N7eIwx3mlViUrqi2_f9flP9eXqcpW_yPzhzKNJ-naYYsju_vvgX1Edj5s</recordid><startdate>19920128</startdate><enddate>19920128</enddate><creator>Mullins, Stephen T</creator><creator>Annan, Nikoi K</creator><creator>Cook, Peter R</creator><creator>Lowe, Gordon</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920128</creationdate><title>Bisintercalators of DNA with a rigid linker in an extended configuration</title><author>Mullins, Stephen T ; Annan, Nikoi K ; Cook, Peter R ; Lowe, Gordon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a383t-156da6a396bb60c781a38c5e38b867b0cd12dad5ba236ac4625dcfc36b55181d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Acridines - chemical synthesis</topic><topic>Acridines - chemistry</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Biological and medical sciences</topic><topic>DNA - chemistry</topic><topic>Dna, deoxyribonucleoproteins</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Indicators and Reagents</topic><topic>Intercalating Agents - chemistry</topic><topic>Ligands</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Models, Structural</topic><topic>Molecular Structure</topic><topic>Nucleic acids</topic><topic>Phenanthridines - chemical synthesis</topic><topic>Phenanthridines - chemistry</topic><topic>Plasmids</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mullins, Stephen T</creatorcontrib><creatorcontrib>Annan, Nikoi K</creatorcontrib><creatorcontrib>Cook, Peter R</creatorcontrib><creatorcontrib>Lowe, Gordon</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemistry (Easton)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mullins, Stephen T</au><au>Annan, Nikoi K</au><au>Cook, Peter R</au><au>Lowe, Gordon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bisintercalators of DNA with a rigid linker in an extended configuration</atitle><jtitle>Biochemistry (Easton)</jtitle><addtitle>Biochemistry</addtitle><date>1992-01-28</date><risdate>1992</risdate><volume>31</volume><issue>3</issue><spage>842</spage><epage>849</epage><pages>842-849</pages><issn>0006-2960</issn><eissn>1520-4995</eissn><abstract>A new class of DNA bisintercalators is reported in which phenanthridinium or acridinium rings are connected by rigid and extended linkers of varied length. Cross-linking of DNA by bisintercalation is inferred from the unwinding and folding of linear DNA induced by the compound; after ligation and removal of the bisintercalator, superhelical circles, catenanes, and knots that bear an imprint of the bisintercalator are observed. These novel bisintercalators are of interest because they can be used to probe the organization of DNA in three-dimensional space, especially near sites of replication, recombination, or topoisomerase action, where two duplexes must be in close proximity.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>1731942</pmid><doi>10.1021/bi00118a029</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-2960 |
| ispartof | Biochemistry (Easton), 1992-01, Vol.31 (3), p.842-849 |
| issn | 0006-2960 1520-4995 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72780634 |
| source | MEDLINE; ACS Publications |
| subjects | Acridines - chemical synthesis Acridines - chemistry Analytical, structural and metabolic biochemistry Biological and medical sciences DNA - chemistry Dna, deoxyribonucleoproteins Fundamental and applied biological sciences. Psychology Indicators and Reagents Intercalating Agents - chemistry Ligands Magnetic Resonance Spectroscopy Models, Structural Molecular Structure Nucleic acids Phenanthridines - chemical synthesis Phenanthridines - chemistry Plasmids Structure-Activity Relationship |
| title | Bisintercalators of DNA with a rigid linker in an extended configuration |
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