MMP-9 and EBA immunoreactivity after papaverine mediated opening of the blood–brain barrier

Papaverine is a non-specific vasodilatory drug, which was found to unexpectedly cause opening of the blood–brain barrier (BBB). We studied the expression of two endothelial cell related markers, endothelial barrier antigen (EBA) as a marker of BBB intactness, and matrix metalloproteinase-9 (MMP-9),...

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Veröffentlicht in:	Neuroreport 2002-12, Vol.13 (17), p.2217-2221
Hauptverfasser:	Bhattacharjee, Abesh Kumar, Kondoh, Takeshi, Ikeda, Mitsuru, Kohmura, Eiji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Surface - drug effects Antigens, Surface - metabolism Biological and medical sciences Blood-Brain Barrier - drug effects Blood-Brain Barrier - physiology Brain - cytology Brain - drug effects Brain - metabolism Cerebral Arteries - drug effects Cerebral Arteries - enzymology Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Diffusion - drug effects Endothelium, Vascular - drug effects Endothelium, Vascular - enzymology Evans Blue Fundamental and applied biological sciences. Psychology Immunohistochemistry Male Matrix Metalloproteinase 9 - drug effects Matrix Metalloproteinase 9 - metabolism Microcirculation - drug effects Microcirculation - enzymology Papaverine - pharmacology Rats Rats, Sprague-Dawley Reaction Time - drug effects Reaction Time - physiology Recovery of Function - drug effects Recovery of Function - physiology Vertebrates: nervous system and sense organs
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