A selective somatostatin type-2 receptor agonist inhibits neointimal thickening and enhances endothelial cell growth and morphology following aortic balloon injury in the rabbit

Somatostatin analogs have been shown to inhibit vascular smooth muscle cell (VSMC) proliferation and attenuate neointimal thickening following experimental balloon catheter injury. In this study, the effects of a selective agonist for the somatostatin receptor subtype 2, PRL-2486, on neointimal thic...

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Veröffentlicht in:	Molecular and cellular biochemistry 2002-11, Vol.240 (1-2), p.31-37
Hauptverfasser:	Schiller, Natalie K, Timothy, Alvin M, Aurora, Harmeet S, Chen, I-Li, Coy, David H, Murphy, William A, Akers, Donald L, Fonseca, Vivian A, Kadowitz, Philip J, McNamara, Dennis B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - injuries Aorta - pathology Aorta - ultrastructure Catheterization - adverse effects Cell Division - drug effects Cell morphology Cell Size - drug effects Cells Disease Models, Animal Endothelium, Vascular - drug effects Endothelium, Vascular - injuries Endothelium, Vascular - pathology Male Medical instruments Microscopy, Electron Muscular system Rabbits Receptors, Somatostatin - agonists Regrowth Sensitivity and Specificity Tunica Intima - drug effects Tunica Intima - injuries Tunica Intima - pathology
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