ADAM-9 Is an Insulin-like Growth Factor Binding Protein-5 Protease Produced and Secreted by Human Osteoblasts

IGF binding protein-5 (BP-5) is an important bone formation regulator. Therefore, elucidation of the identity of IGF binding protein-5 (BP-5) protease produced by osteoblasts is important for our understanding of the molecular pathways that control the action of BP-5. In this regard, BP-5 protease p...

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Veröffentlicht in:	Biochemistry (Easton) 2002-12, Vol.41 (51), p.15394-15403
Hauptverfasser:	Mohan, Subburaman, Thompson, Garrett R, Amaar, Yousef G, Hathaway, Gary, Tschesche, Harald, Baylink, David J
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins alpha-Macroglobulins - biosynthesis alpha-Macroglobulins - chemistry Cell Line, Transformed Cells, Cultured Disintegrins Electrophoresis, Polyacrylamide Gel Humans Insulin-Like Growth Factor Binding Protein 5 - metabolism meltrin-^g Membrane Proteins - biosynthesis Membrane Proteins - chemistry Membrane Proteins - isolation & purification Membrane Proteins - metabolism Metalloendopeptidases - biosynthesis Metalloendopeptidases - chemistry Metalloendopeptidases - isolation & purification Metalloendopeptidases - metabolism Muscle Proteins - biosynthesis Muscle Proteins - chemistry Muscle Proteins - isolation & purification Muscle Proteins - metabolism Osteoblasts - enzymology Osteoblasts - metabolism Peptide Fragments - chemistry Peptide Fragments - isolation & purification Protein Binding Recombinant Proteins - biosynthesis Recombinant Proteins - chemistry Recombinant Proteins - isolation & purification Sequence Analysis, Protein Substrate Specificity Tumor Cells, Cultured
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