Atherosclerotic Lesions and Mitochondria DNA Deletions in Brain Microvessels as a Central Target for the Development of Human AD and AD-Like Pathology in Aged Transgenic Mice

: We have studied the ultrastructural features of vascular lesions and mitochondria in brain vascular wall cells from human AD brain biopsy, human short postmortem brain tissues, and yeast artificial chromosome (YAC) and C57B6/SJL transgenic positive (Tg+) mice overexpressing amyloid beta precursor...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2002-11, Vol.977 (1), p.45-64
Hauptverfasser:	ALIEV, GJUMRAKCH, SEYIDOVA, DILARA, NEAL, MAXWELL L., SHI, JIONG, LAMB, BRUCE T., SIEDLAK, SANDRA L., VINTERS, HARRY V., HEAD, ELIZABETH, PERRY, GEORGE, LAMANNA, JOSEPH C., FRIEDLAND, ROBERT P., COTMAN, CARL W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - genetics Alzheimer Disease - pathology Alzheimer's disease Amyloid beta-Protein Precursor - genetics Animals Arteriosclerosis - pathology Base Sequence Cerebrovascular Disorders - pathology DNA Probes DNA, Mitochondrial - genetics free radicals Humans metabolism Mice Mice, Transgenic Microcirculation - pathology mitochondria Models, Animal neurodegeneration Oxidative Stress Sequence Deletion vascular factors
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