Multidrug resistance phenotype associated with selection of an aminopterin resistant dog kidney cell line

A determination of the mechanisms of drug resistance in tumour cells is important for developing strategies to combat such resistance in persons receiving chemotherapy. This report describes a combined cellular, biochemical, and molecular analysis of a dog kidney cell line selected for resistance to...

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Veröffentlicht in:	Pharmacogenetics (London) 1991-12, Vol.1 (3), p.149-160
Hauptverfasser:	Turker, M S, Duffin, K Z, Smith, A C, Martin, G M, Martin, A W, DiMartino, D L, Kersey, D S
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminopterin - pharmacokinetics Aminopterin - pharmacology Animals ATP-Binding Cassette, Sub-Family B, Member 1 Cell Line Colchicine - pharmacology Dogs Drug Resistance - genetics Immunohistochemistry Kidney Membrane Glycoproteins - metabolism Phenotype RNA, Messenger - genetics RNA, Messenger - metabolism Tetrahydrofolate Dehydrogenase - metabolism
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