Metabolic Response to a Mixed Meal in Obese and Lean Women from Two South African Populations
Objective: Lower lipid and insulin levels are found during a glucose‐tolerance test in obese black than obese white South African women. Therefore, β‐cell function and lipid metabolism were compared in these populations during a mixed meal. Research Methods and Procedures: Blood concentrations of gl...
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| Veröffentlicht in: | Obesity (Silver Spring, Md.) Md.), 2002-12, Vol.10 (12), p.1207-1216 |
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| container_title | Obesity (Silver Spring, Md.) |
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| creator | Punyadeera, Chamindie Crowther, Nigel J. Merwe, Maria‐Terésa Toman, Marketa Immelman, Andrew Ronnie Schlaphoff, Glen P. Gray, Ian Peter |
| description | Objective: Lower lipid and insulin levels are found during a glucose‐tolerance test in obese black than obese white South African women. Therefore, β‐cell function and lipid metabolism were compared in these populations during a mixed meal.
Research Methods and Procedures: Blood concentrations of glucose, free fatty acids (FFAs), insulin, lipograms, and in vivo FFA oxidation were determined at fasting and for 7 hours after oral administration of a mixed emulsion containing glucose‐casein‐sucrose‐lipid and [1‐13C] palmitic acid in 8 lean black women (LBW), 10 obese black women (OBW), 9 lean white women (LWW), and 10 obese white women (OWW). Subcutaneous and visceral fat mass was assessed by computerized tomography.
Results: Visceral fat area was higher in OWW (152.7 ± 17.0 cm2) than OBW (80.0 ± 6.7 cm2; p < 0.01). In OBW, 30‐minute insulin levels were higher (604.3 ± 117.6 pM) than OWW (311.0 ± 42.9 pM; p < 0.05). Total triglyceride was higher in OWW (706.7 ± 96.0 mM × 7 hours) than OBW (465.7 ± 48.2 mM × 7 hours; p < 0.05) and correlated with visceral fat area (β = 0.38, p = 0.05). Palmitate oxidation was higher in lean than obese women in both ethnic groups and correlated negatively with fat mass (β = −0.58, p < 0.005).
Discussion: The higher 30‐minute insulin response in OBW may reflect a higher insulinotropic effect of FFAs or glucose. The elevated triglyceride level of OWW may be due to their higher visceral fat mass and possibly reduced clearance by adipose tissue. |
| doi_str_mv | 10.1038/oby.2002.165 |
| format | Article |
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Research Methods and Procedures: Blood concentrations of glucose, free fatty acids (FFAs), insulin, lipograms, and in vivo FFA oxidation were determined at fasting and for 7 hours after oral administration of a mixed emulsion containing glucose‐casein‐sucrose‐lipid and [1‐13C] palmitic acid in 8 lean black women (LBW), 10 obese black women (OBW), 9 lean white women (LWW), and 10 obese white women (OWW). Subcutaneous and visceral fat mass was assessed by computerized tomography.
Results: Visceral fat area was higher in OWW (152.7 ± 17.0 cm2) than OBW (80.0 ± 6.7 cm2; p < 0.01). In OBW, 30‐minute insulin levels were higher (604.3 ± 117.6 pM) than OWW (311.0 ± 42.9 pM; p < 0.05). Total triglyceride was higher in OWW (706.7 ± 96.0 mM × 7 hours) than OBW (465.7 ± 48.2 mM × 7 hours; p < 0.05) and correlated with visceral fat area (β = 0.38, p = 0.05). Palmitate oxidation was higher in lean than obese women in both ethnic groups and correlated negatively with fat mass (β = −0.58, p < 0.005).
Discussion: The higher 30‐minute insulin response in OBW may reflect a higher insulinotropic effect of FFAs or glucose. The elevated triglyceride level of OWW may be due to their higher visceral fat mass and possibly reduced clearance by adipose tissue.</description><identifier>ISSN: 1071-7323</identifier><identifier>ISSN: 1930-7381</identifier><identifier>EISSN: 1550-8528</identifier><identifier>EISSN: 1930-739X</identifier><identifier>DOI: 10.1038/oby.2002.165</identifier><identifier>PMID: 12490664</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adipose Tissue ; African Continental Ancestry Group ; Blood Glucose - analysis ; Body Composition ; Body Constitution ; Carbon Isotopes ; Caseins - administration & dosage ; Dietary Fats - administration & dosage ; Emulsions ; European Continental Ancestry Group ; Fasting ; Fatty Acids, Nonesterified - blood ; Female ; Food ; Glucose - administration & dosage ; Glucose Tolerance Test ; Humans ; in vivo lipid oxidation ; Insulin - blood ; insulin secretion ; Lipids - blood ; Middle Aged ; Obesity - metabolism ; Oxidation-Reduction ; Palmitic Acid - administration & dosage ; South Africa ; Sucrose - administration & dosage ; Tomography, X-Ray Computed ; triglyceride metabolism ; Triglycerides - blood ; Viscera ; visceral obesity</subject><ispartof>Obesity (Silver Spring, Md.), 2002-12, Vol.10 (12), p.1207-1216</ispartof><rights>2002 North American Association for the Study of Obesity (NAASO)</rights><rights>Copyright Nature Publishing Group Dec 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3957-7056749aa9c67d88d327ce6b0df7a26580db7e6d36ab08d065934aa96356106d3</citedby><cites>FETCH-LOGICAL-c3957-7056749aa9c67d88d327ce6b0df7a26580db7e6d36ab08d065934aa96356106d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1038%2Foby.2002.165$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1038%2Foby.2002.165$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27903,27904,45553,45554,46388,46812</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12490664$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Punyadeera, Chamindie</creatorcontrib><creatorcontrib>Crowther, Nigel J.</creatorcontrib><creatorcontrib>Merwe, Maria‐Terésa</creatorcontrib><creatorcontrib>Toman, Marketa</creatorcontrib><creatorcontrib>Immelman, Andrew Ronnie</creatorcontrib><creatorcontrib>Schlaphoff, Glen P.</creatorcontrib><creatorcontrib>Gray, Ian Peter</creatorcontrib><title>Metabolic Response to a Mixed Meal in Obese and Lean Women from Two South African Populations</title><title>Obesity (Silver Spring, Md.)</title><addtitle>Obes Res</addtitle><description>Objective: Lower lipid and insulin levels are found during a glucose‐tolerance test in obese black than obese white South African women. Therefore, β‐cell function and lipid metabolism were compared in these populations during a mixed meal.
Research Methods and Procedures: Blood concentrations of glucose, free fatty acids (FFAs), insulin, lipograms, and in vivo FFA oxidation were determined at fasting and for 7 hours after oral administration of a mixed emulsion containing glucose‐casein‐sucrose‐lipid and [1‐13C] palmitic acid in 8 lean black women (LBW), 10 obese black women (OBW), 9 lean white women (LWW), and 10 obese white women (OWW). Subcutaneous and visceral fat mass was assessed by computerized tomography.
Results: Visceral fat area was higher in OWW (152.7 ± 17.0 cm2) than OBW (80.0 ± 6.7 cm2; p < 0.01). In OBW, 30‐minute insulin levels were higher (604.3 ± 117.6 pM) than OWW (311.0 ± 42.9 pM; p < 0.05). Total triglyceride was higher in OWW (706.7 ± 96.0 mM × 7 hours) than OBW (465.7 ± 48.2 mM × 7 hours; p < 0.05) and correlated with visceral fat area (β = 0.38, p = 0.05). Palmitate oxidation was higher in lean than obese women in both ethnic groups and correlated negatively with fat mass (β = −0.58, p < 0.005).
Discussion: The higher 30‐minute insulin response in OBW may reflect a higher insulinotropic effect of FFAs or glucose. The elevated triglyceride level of OWW may be due to their higher visceral fat mass and possibly reduced clearance by adipose tissue.</description><subject>Adipose Tissue</subject><subject>African Continental Ancestry Group</subject><subject>Blood Glucose - analysis</subject><subject>Body Composition</subject><subject>Body Constitution</subject><subject>Carbon Isotopes</subject><subject>Caseins - administration & dosage</subject><subject>Dietary Fats - administration & dosage</subject><subject>Emulsions</subject><subject>European Continental Ancestry Group</subject><subject>Fasting</subject><subject>Fatty Acids, Nonesterified - blood</subject><subject>Female</subject><subject>Food</subject><subject>Glucose - administration & dosage</subject><subject>Glucose Tolerance Test</subject><subject>Humans</subject><subject>in vivo lipid oxidation</subject><subject>Insulin - blood</subject><subject>insulin secretion</subject><subject>Lipids - blood</subject><subject>Middle Aged</subject><subject>Obesity - metabolism</subject><subject>Oxidation-Reduction</subject><subject>Palmitic Acid - administration & dosage</subject><subject>South Africa</subject><subject>Sucrose - administration & dosage</subject><subject>Tomography, X-Ray Computed</subject><subject>triglyceride metabolism</subject><subject>Triglycerides - blood</subject><subject>Viscera</subject><subject>visceral obesity</subject><issn>1071-7323</issn><issn>1930-7381</issn><issn>1550-8528</issn><issn>1930-739X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90MtLxDAQBvAgiuvr5lkCgie7Tprm0aOKL9hlRVfEg5S0mWKlbdamRfe_N7ILggdPGTI_PoaPkEMGYwZcn7l8OY4B4jGTYoPsMCEg0iLWm2EGxSLFYz4iu96_AzCZaLZNRixOUpAy2SGvU-xN7uqqoA_oF671SHtHDZ1WX2jpFE1Nq5bOcgwL01o6QdPSZ9dgS8vONXT-6eijG_o3el52VRGW924x1KavQtY-2SpN7fFg_e6Rp-ur-eVtNJnd3F2eT6KCp0JFCoRUSWpMWkhltbY8VgXKHGypTCyFBpsrlJZLk4O2IEXKk6AlF5JB-N8jJ6vcRec-BvR91lS-wLo2LbrBZypWSgJnAR7_ge9u6NpwWxbKhJTp0FBQpytVdM77Dsts0VWN6ZYB_TidhdKzn9KzUHrgR-vQIW_Q_uJ1ywGwFfisalz-G5bNLl5YIhX_BvlEih0</recordid><startdate>200212</startdate><enddate>200212</enddate><creator>Punyadeera, Chamindie</creator><creator>Crowther, Nigel J.</creator><creator>Merwe, Maria‐Terésa</creator><creator>Toman, Marketa</creator><creator>Immelman, Andrew Ronnie</creator><creator>Schlaphoff, Glen P.</creator><creator>Gray, Ian Peter</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200212</creationdate><title>Metabolic Response to a Mixed Meal in Obese and Lean Women from Two South African Populations</title><author>Punyadeera, Chamindie ; Crowther, Nigel J. ; Merwe, Maria‐Terésa ; Toman, Marketa ; Immelman, Andrew Ronnie ; Schlaphoff, Glen P. ; Gray, Ian Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3957-7056749aa9c67d88d327ce6b0df7a26580db7e6d36ab08d065934aa96356106d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adipose Tissue</topic><topic>African Continental Ancestry Group</topic><topic>Blood Glucose - analysis</topic><topic>Body Composition</topic><topic>Body Constitution</topic><topic>Carbon Isotopes</topic><topic>Caseins - administration & dosage</topic><topic>Dietary Fats - administration & dosage</topic><topic>Emulsions</topic><topic>European Continental Ancestry Group</topic><topic>Fasting</topic><topic>Fatty Acids, Nonesterified - blood</topic><topic>Female</topic><topic>Food</topic><topic>Glucose - administration & dosage</topic><topic>Glucose Tolerance Test</topic><topic>Humans</topic><topic>in vivo lipid oxidation</topic><topic>Insulin - blood</topic><topic>insulin secretion</topic><topic>Lipids - blood</topic><topic>Middle Aged</topic><topic>Obesity - metabolism</topic><topic>Oxidation-Reduction</topic><topic>Palmitic Acid - administration & dosage</topic><topic>South Africa</topic><topic>Sucrose - administration & dosage</topic><topic>Tomography, X-Ray Computed</topic><topic>triglyceride metabolism</topic><topic>Triglycerides - blood</topic><topic>Viscera</topic><topic>visceral obesity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Punyadeera, Chamindie</creatorcontrib><creatorcontrib>Crowther, Nigel J.</creatorcontrib><creatorcontrib>Merwe, Maria‐Terésa</creatorcontrib><creatorcontrib>Toman, Marketa</creatorcontrib><creatorcontrib>Immelman, Andrew Ronnie</creatorcontrib><creatorcontrib>Schlaphoff, Glen P.</creatorcontrib><creatorcontrib>Gray, Ian Peter</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity (Silver Spring, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Punyadeera, Chamindie</au><au>Crowther, Nigel J.</au><au>Merwe, Maria‐Terésa</au><au>Toman, Marketa</au><au>Immelman, Andrew Ronnie</au><au>Schlaphoff, Glen P.</au><au>Gray, Ian Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolic Response to a Mixed Meal in Obese and Lean Women from Two South African Populations</atitle><jtitle>Obesity (Silver Spring, Md.)</jtitle><addtitle>Obes Res</addtitle><date>2002-12</date><risdate>2002</risdate><volume>10</volume><issue>12</issue><spage>1207</spage><epage>1216</epage><pages>1207-1216</pages><issn>1071-7323</issn><issn>1930-7381</issn><eissn>1550-8528</eissn><eissn>1930-739X</eissn><abstract>Objective: Lower lipid and insulin levels are found during a glucose‐tolerance test in obese black than obese white South African women. Therefore, β‐cell function and lipid metabolism were compared in these populations during a mixed meal.
Research Methods and Procedures: Blood concentrations of glucose, free fatty acids (FFAs), insulin, lipograms, and in vivo FFA oxidation were determined at fasting and for 7 hours after oral administration of a mixed emulsion containing glucose‐casein‐sucrose‐lipid and [1‐13C] palmitic acid in 8 lean black women (LBW), 10 obese black women (OBW), 9 lean white women (LWW), and 10 obese white women (OWW). Subcutaneous and visceral fat mass was assessed by computerized tomography.
Results: Visceral fat area was higher in OWW (152.7 ± 17.0 cm2) than OBW (80.0 ± 6.7 cm2; p < 0.01). In OBW, 30‐minute insulin levels were higher (604.3 ± 117.6 pM) than OWW (311.0 ± 42.9 pM; p < 0.05). Total triglyceride was higher in OWW (706.7 ± 96.0 mM × 7 hours) than OBW (465.7 ± 48.2 mM × 7 hours; p < 0.05) and correlated with visceral fat area (β = 0.38, p = 0.05). Palmitate oxidation was higher in lean than obese women in both ethnic groups and correlated negatively with fat mass (β = −0.58, p < 0.005).
Discussion: The higher 30‐minute insulin response in OBW may reflect a higher insulinotropic effect of FFAs or glucose. The elevated triglyceride level of OWW may be due to their higher visceral fat mass and possibly reduced clearance by adipose tissue.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>12490664</pmid><doi>10.1038/oby.2002.165</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Free Content; EZB-FREE-00999 freely available EZB journals |
| subjects | Adipose Tissue African Continental Ancestry Group Blood Glucose - analysis Body Composition Body Constitution Carbon Isotopes Caseins - administration & dosage Dietary Fats - administration & dosage Emulsions European Continental Ancestry Group Fasting Fatty Acids, Nonesterified - blood Female Food Glucose - administration & dosage Glucose Tolerance Test Humans in vivo lipid oxidation Insulin - blood insulin secretion Lipids - blood Middle Aged Obesity - metabolism Oxidation-Reduction Palmitic Acid - administration & dosage South Africa Sucrose - administration & dosage Tomography, X-Ray Computed triglyceride metabolism Triglycerides - blood Viscera visceral obesity |
| title | Metabolic Response to a Mixed Meal in Obese and Lean Women from Two South African Populations |
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