Autologous Transplantation of Canine Long-Term Marrow Culture Cells Genetically Marked by Retroviral Vectors

Retroviral infection of bone marrow cells in long-term marrow cultures (LTMCs) offers several theoretical advantages over other methods for gene transfer into hematopoietic stem cells. To investigate the feasibility of this approach in a large animal model system, we subjected LTMCs from nine dogs t...

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Veröffentlicht in:	Blood 1992-01, Vol.79 (2), p.356-364
Hauptverfasser:	Carter, Ronald F., Abrams-Ogg, Anthony C.G., Dick, John E., Kruth, Steven A., Valli, Victor E., Kamel-Reid, Suzanne, Dubé, Ian D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Base Sequence Biological and medical sciences Bone Marrow - microbiology Bone Marrow Cells Bone Marrow Transplantation Bone marrow, stem cells transplantation. Graft versus host reaction Cells, Cultured DNA - analysis Dogs Genetic Markers Genetic Vectors Granulocytes - chemistry Hematopoietic Stem Cells - chemistry Kanamycin Kinase Macrophages - chemistry Medical sciences Molecular Sequence Data Phosphotransferases - genetics Polymerase Chain Reaction Retroviridae - genetics Transfection Transfusions. Complications. Transfusion reactions. Cell and gene therapy
Online-Zugang:	Volltext
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