Deficiency of Glutathione Peroxidase-1 Sensitizes Hyperhomocysteinemic Mice to Endothelial Dysfunction

OBJECTIVE—We tested the hypothesis that deficiency of cellular glutathione peroxidase (GPx-1) enhances susceptibility to endothelial dysfunction in mice with moderate hyperhomocysteinemia. METHODS AND RESULTS—Mice that were wild type (Gpx1), heterozygous (Gpx1), or homozygous (Gpx1) for the mutated...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2002-12, Vol.22 (12), p.1996-2002
Hauptverfasser:	Dayal, Sanjana, Brown, Kara L, Weydert, Christine J, Oberley, Larry W, Arning, Erland, Bottiglieri, Teodoro, Faraci, Frank M, Lentz, Steven R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta, Thoracic - drug effects Aorta, Thoracic - enzymology Biological and medical sciences Cardiology. Vascular system Carotid Arteries - chemistry Carotid Arteries - drug effects Carotid Arteries - enzymology Catalase - metabolism Coronary heart disease Diet Endothelium, Vascular - enzymology Endothelium, Vascular - physiopathology Ethidium - analogs & derivatives Ethidium - analysis Glutathione Peroxidase - blood Glutathione Peroxidase - deficiency Glutathione Peroxidase - genetics Heart Homocysteine - blood Hyperhomocysteinemia - blood Hyperhomocysteinemia - enzymology Hyperhomocysteinemia - genetics Liver - enzymology Medical sciences Methionine - blood Methionine - metabolism Mice Mice, Congenic Mice, Inbred C57BL Mice, Knockout Superoxide Dismutase - metabolism Superoxides - analysis Vasomotor System - drug effects Vasomotor System - enzymology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!