Hyperzincaemia and hypercalprotectinaemia: a new disorder of zinc metabolism
Calprotectin (complex of S100A8 and S100A9) is the major calcium and zinc-binding protein of phagocytes. We report a new syndrome with recurrent infections, inflammation, and hyperzincaemia associated with excessively high plasma concentrations of calprotectin. We measured calprotectin in plasma and...
Gespeichert in:
| Veröffentlicht in: | The Lancet (British edition) 2002-11, Vol.360 (9347), p.1742-1745 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1745 |
|---|---|
| container_issue | 9347 |
| container_start_page | 1742 |
| container_title | The Lancet (British edition) |
| container_volume | 360 |
| creator | Sampson, Barry Fagerhol, Magne K Sunderkötter, Cord Golden, Barbara E Richmond, Peter Klein, Nigel Kovar, Ilya Z Beattie, John H Wolska-Kusnierz, Beata Saito, Yoshiaki Roth, Johannes |
| description | Calprotectin (complex of S100A8 and S100A9) is the major calcium and zinc-binding protein of phagocytes. We report a new syndrome with recurrent infections, inflammation, and hyperzincaemia associated with excessively high plasma concentrations of calprotectin.
We measured calprotectin in plasma and protein fractions by ELISA assay and zinc by atomic absorption spectrometry. Plasma proteins were fractionated by size exclusion chromatography and electrophoresis. Mass spectra of purified proteins were determined by MALDI-TOFMS.
We assessed five patients, two of whom are related. All patients had much the same biochemical findings of hyperzincaemia (77–200 μmol/L, reference range 11–18 μmol/L) and raised plasma calprotectin concentrations (1·4–6·5 g/L, reference range |
| doi_str_mv | 10.1016/S0140-6736(02)11683-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72773877</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0140673602116837</els_id><sourcerecordid>72773877</sourcerecordid><originalsourceid>FETCH-LOGICAL-c388t-ab07e64737e61d147be901bb3d24c2dd66fae6431d087691592b89609590d6053</originalsourceid><addsrcrecordid>eNqFkE1LxDAQhoMouq7-BKV4ED1UJ22apF5ExC9Y8KCCt5Amsxjpx5p0Ff31pruLghcPSSDzzJvJQ8gehRMKlJ8-AGWQcpHzI8iOKeUyT8UaGVEmWFow8bxORj_IFtkO4RUAGIdik2zRjElgmRyRye3nDP2Xa43GxulEtzZ5Ga6Mrme-69H0rl2UzhKdtPiRWBc6b9En3TQZ-pIGe111tQvNDtmY6jrg7uock6frq8fL23Ryf3N3eTFJTS5ln-oKBHIm8rhTGweusARaVbnNmMms5XyqYz2nFqTgJS3KrJIlh7IowcYP5GNyuMyNE77NMfSqccFgXesWu3lQIhMil3GNycEf8LWb-zbOpmhZgiy4pBEqlpDxXQgep2rmXaP9p6KgBtdq4VoNIhVkauFaDeH7q_B51aD97VrJjcD5EsDo4t2hV8E4bA1a56NXZTv3zxPfUiaNMQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>199085681</pqid></control><display><type>article</type><title>Hyperzincaemia and hypercalprotectinaemia: a new disorder of zinc metabolism</title><source>MEDLINE</source><source>Business Source Complete</source><source>ScienceDirect Journals (5 years ago - present)</source><source>ProQuest Central UK/Ireland</source><creator>Sampson, Barry ; Fagerhol, Magne K ; Sunderkötter, Cord ; Golden, Barbara E ; Richmond, Peter ; Klein, Nigel ; Kovar, Ilya Z ; Beattie, John H ; Wolska-Kusnierz, Beata ; Saito, Yoshiaki ; Roth, Johannes</creator><creatorcontrib>Sampson, Barry ; Fagerhol, Magne K ; Sunderkötter, Cord ; Golden, Barbara E ; Richmond, Peter ; Klein, Nigel ; Kovar, Ilya Z ; Beattie, John H ; Wolska-Kusnierz, Beata ; Saito, Yoshiaki ; Roth, Johannes</creatorcontrib><description>Calprotectin (complex of S100A8 and S100A9) is the major calcium and zinc-binding protein of phagocytes. We report a new syndrome with recurrent infections, inflammation, and hyperzincaemia associated with excessively high plasma concentrations of calprotectin.
We measured calprotectin in plasma and protein fractions by ELISA assay and zinc by atomic absorption spectrometry. Plasma proteins were fractionated by size exclusion chromatography and electrophoresis. Mass spectra of purified proteins were determined by MALDI-TOFMS.
We assessed five patients, two of whom are related. All patients had much the same biochemical findings of hyperzincaemia (77–200 μmol/L, reference range 11–18 μmol/L) and raised plasma calprotectin concentrations (1·4–6·5 g/L, reference range <1 mg/L). All patients presented with recurrent infections, hepatosplenomegaly, anaemia, and evidence of systemic inflammation. Three patients had cutaneous inflammation and three presented in infancy with severe growth failure. Size exclusion chromatography showed that zinc and calprotectin were associated in a broad fraction with molecular weight range 100–300 kDa. Analysis by electrophoresis and mass spectrometry showed that the patients' protein contained normal S100A8 and S100A9 subunits.
Dysregulation of zinc metabolism associated with accumulation in plasma of S100A8 and S100A9 defines a new disease, which encompasses a pathological role for dysregulation of two members of the large S100 protein family.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(02)11683-7</identifier><identifier>PMID: 12480428</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Atomic absorption spectroscopy ; Calcium ; Child ; Chromatography ; Electrophoresis ; Female ; Humans ; Immune response ; Isotope studies ; Leukocyte L1 Antigen Complex - blood ; Leukocyte L1 Antigen Complex - metabolism ; Leukocyte L1 Antigen Complex - physiology ; Lymphocytes ; Male ; Mass spectra ; Mass spectrometry ; Medical disorders ; Medical research ; Metabolism ; Pathology ; Proteins ; Spectral analysis ; Stable isotopes ; Syndrome ; Zinc ; Zinc - blood ; Zinc - metabolism</subject><ispartof>The Lancet (British edition), 2002-11, Vol.360 (9347), p.1742-1745</ispartof><rights>2002 Elsevier Ltd</rights><rights>Copyright Lancet Ltd. Nov 30, 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-ab07e64737e61d147be901bb3d24c2dd66fae6431d087691592b89609590d6053</citedby><cites>FETCH-LOGICAL-c388t-ab07e64737e61d147be901bb3d24c2dd66fae6431d087691592b89609590d6053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/199085681?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72341</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12480428$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sampson, Barry</creatorcontrib><creatorcontrib>Fagerhol, Magne K</creatorcontrib><creatorcontrib>Sunderkötter, Cord</creatorcontrib><creatorcontrib>Golden, Barbara E</creatorcontrib><creatorcontrib>Richmond, Peter</creatorcontrib><creatorcontrib>Klein, Nigel</creatorcontrib><creatorcontrib>Kovar, Ilya Z</creatorcontrib><creatorcontrib>Beattie, John H</creatorcontrib><creatorcontrib>Wolska-Kusnierz, Beata</creatorcontrib><creatorcontrib>Saito, Yoshiaki</creatorcontrib><creatorcontrib>Roth, Johannes</creatorcontrib><title>Hyperzincaemia and hypercalprotectinaemia: a new disorder of zinc metabolism</title><title>The Lancet (British edition)</title><addtitle>Lancet</addtitle><description>Calprotectin (complex of S100A8 and S100A9) is the major calcium and zinc-binding protein of phagocytes. We report a new syndrome with recurrent infections, inflammation, and hyperzincaemia associated with excessively high plasma concentrations of calprotectin.
We measured calprotectin in plasma and protein fractions by ELISA assay and zinc by atomic absorption spectrometry. Plasma proteins were fractionated by size exclusion chromatography and electrophoresis. Mass spectra of purified proteins were determined by MALDI-TOFMS.
We assessed five patients, two of whom are related. All patients had much the same biochemical findings of hyperzincaemia (77–200 μmol/L, reference range 11–18 μmol/L) and raised plasma calprotectin concentrations (1·4–6·5 g/L, reference range <1 mg/L). All patients presented with recurrent infections, hepatosplenomegaly, anaemia, and evidence of systemic inflammation. Three patients had cutaneous inflammation and three presented in infancy with severe growth failure. Size exclusion chromatography showed that zinc and calprotectin were associated in a broad fraction with molecular weight range 100–300 kDa. Analysis by electrophoresis and mass spectrometry showed that the patients' protein contained normal S100A8 and S100A9 subunits.
Dysregulation of zinc metabolism associated with accumulation in plasma of S100A8 and S100A9 defines a new disease, which encompasses a pathological role for dysregulation of two members of the large S100 protein family.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Atomic absorption spectroscopy</subject><subject>Calcium</subject><subject>Child</subject><subject>Chromatography</subject><subject>Electrophoresis</subject><subject>Female</subject><subject>Humans</subject><subject>Immune response</subject><subject>Isotope studies</subject><subject>Leukocyte L1 Antigen Complex - blood</subject><subject>Leukocyte L1 Antigen Complex - metabolism</subject><subject>Leukocyte L1 Antigen Complex - physiology</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Mass spectra</subject><subject>Mass spectrometry</subject><subject>Medical disorders</subject><subject>Medical research</subject><subject>Metabolism</subject><subject>Pathology</subject><subject>Proteins</subject><subject>Spectral analysis</subject><subject>Stable isotopes</subject><subject>Syndrome</subject><subject>Zinc</subject><subject>Zinc - blood</subject><subject>Zinc - metabolism</subject><issn>0140-6736</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkE1LxDAQhoMouq7-BKV4ED1UJ22apF5ExC9Y8KCCt5Amsxjpx5p0Ff31pruLghcPSSDzzJvJQ8gehRMKlJ8-AGWQcpHzI8iOKeUyT8UaGVEmWFow8bxORj_IFtkO4RUAGIdik2zRjElgmRyRye3nDP2Xa43GxulEtzZ5Ga6Mrme-69H0rl2UzhKdtPiRWBc6b9En3TQZ-pIGe111tQvNDtmY6jrg7uock6frq8fL23Ryf3N3eTFJTS5ln-oKBHIm8rhTGweusARaVbnNmMms5XyqYz2nFqTgJS3KrJIlh7IowcYP5GNyuMyNE77NMfSqccFgXesWu3lQIhMil3GNycEf8LWb-zbOpmhZgiy4pBEqlpDxXQgep2rmXaP9p6KgBtdq4VoNIhVkauFaDeH7q_B51aD97VrJjcD5EsDo4t2hV8E4bA1a56NXZTv3zxPfUiaNMQ</recordid><startdate>20021130</startdate><enddate>20021130</enddate><creator>Sampson, Barry</creator><creator>Fagerhol, Magne K</creator><creator>Sunderkötter, Cord</creator><creator>Golden, Barbara E</creator><creator>Richmond, Peter</creator><creator>Klein, Nigel</creator><creator>Kovar, Ilya Z</creator><creator>Beattie, John H</creator><creator>Wolska-Kusnierz, Beata</creator><creator>Saito, Yoshiaki</creator><creator>Roth, Johannes</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TT</scope><scope>0TZ</scope><scope>0U~</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88C</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8C2</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>KB~</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20021130</creationdate><title>Hyperzincaemia and hypercalprotectinaemia: a new disorder of zinc metabolism</title><author>Sampson, Barry ; Fagerhol, Magne K ; Sunderkötter, Cord ; Golden, Barbara E ; Richmond, Peter ; Klein, Nigel ; Kovar, Ilya Z ; Beattie, John H ; Wolska-Kusnierz, Beata ; Saito, Yoshiaki ; Roth, Johannes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-ab07e64737e61d147be901bb3d24c2dd66fae6431d087691592b89609590d6053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Atomic absorption spectroscopy</topic><topic>Calcium</topic><topic>Child</topic><topic>Chromatography</topic><topic>Electrophoresis</topic><topic>Female</topic><topic>Humans</topic><topic>Immune response</topic><topic>Isotope studies</topic><topic>Leukocyte L1 Antigen Complex - blood</topic><topic>Leukocyte L1 Antigen Complex - metabolism</topic><topic>Leukocyte L1 Antigen Complex - physiology</topic><topic>Lymphocytes</topic><topic>Male</topic><topic>Mass spectra</topic><topic>Mass spectrometry</topic><topic>Medical disorders</topic><topic>Medical research</topic><topic>Metabolism</topic><topic>Pathology</topic><topic>Proteins</topic><topic>Spectral analysis</topic><topic>Stable isotopes</topic><topic>Syndrome</topic><topic>Zinc</topic><topic>Zinc - blood</topic><topic>Zinc - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sampson, Barry</creatorcontrib><creatorcontrib>Fagerhol, Magne K</creatorcontrib><creatorcontrib>Sunderkötter, Cord</creatorcontrib><creatorcontrib>Golden, Barbara E</creatorcontrib><creatorcontrib>Richmond, Peter</creatorcontrib><creatorcontrib>Klein, Nigel</creatorcontrib><creatorcontrib>Kovar, Ilya Z</creatorcontrib><creatorcontrib>Beattie, John H</creatorcontrib><creatorcontrib>Wolska-Kusnierz, Beata</creatorcontrib><creatorcontrib>Saito, Yoshiaki</creatorcontrib><creatorcontrib>Roth, Johannes</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>News PRO</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Global News & ABI/Inform Professional</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Lancet Titles</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>British Nursing Index</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Newsstand Professional</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>The Lancet (British edition)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sampson, Barry</au><au>Fagerhol, Magne K</au><au>Sunderkötter, Cord</au><au>Golden, Barbara E</au><au>Richmond, Peter</au><au>Klein, Nigel</au><au>Kovar, Ilya Z</au><au>Beattie, John H</au><au>Wolska-Kusnierz, Beata</au><au>Saito, Yoshiaki</au><au>Roth, Johannes</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hyperzincaemia and hypercalprotectinaemia: a new disorder of zinc metabolism</atitle><jtitle>The Lancet (British edition)</jtitle><addtitle>Lancet</addtitle><date>2002-11-30</date><risdate>2002</risdate><volume>360</volume><issue>9347</issue><spage>1742</spage><epage>1745</epage><pages>1742-1745</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><coden>LANCAO</coden><abstract>Calprotectin (complex of S100A8 and S100A9) is the major calcium and zinc-binding protein of phagocytes. We report a new syndrome with recurrent infections, inflammation, and hyperzincaemia associated with excessively high plasma concentrations of calprotectin.
We measured calprotectin in plasma and protein fractions by ELISA assay and zinc by atomic absorption spectrometry. Plasma proteins were fractionated by size exclusion chromatography and electrophoresis. Mass spectra of purified proteins were determined by MALDI-TOFMS.
We assessed five patients, two of whom are related. All patients had much the same biochemical findings of hyperzincaemia (77–200 μmol/L, reference range 11–18 μmol/L) and raised plasma calprotectin concentrations (1·4–6·5 g/L, reference range <1 mg/L). All patients presented with recurrent infections, hepatosplenomegaly, anaemia, and evidence of systemic inflammation. Three patients had cutaneous inflammation and three presented in infancy with severe growth failure. Size exclusion chromatography showed that zinc and calprotectin were associated in a broad fraction with molecular weight range 100–300 kDa. Analysis by electrophoresis and mass spectrometry showed that the patients' protein contained normal S100A8 and S100A9 subunits.
Dysregulation of zinc metabolism associated with accumulation in plasma of S100A8 and S100A9 defines a new disease, which encompasses a pathological role for dysregulation of two members of the large S100 protein family.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>12480428</pmid><doi>10.1016/S0140-6736(02)11683-7</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0140-6736 |
| ispartof | The Lancet (British edition), 2002-11, Vol.360 (9347), p.1742-1745 |
| issn | 0140-6736 1474-547X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72773877 |
| source | MEDLINE; Business Source Complete; ScienceDirect Journals (5 years ago - present); ProQuest Central UK/Ireland |
| subjects | Adolescent Adult Atomic absorption spectroscopy Calcium Child Chromatography Electrophoresis Female Humans Immune response Isotope studies Leukocyte L1 Antigen Complex - blood Leukocyte L1 Antigen Complex - metabolism Leukocyte L1 Antigen Complex - physiology Lymphocytes Male Mass spectra Mass spectrometry Medical disorders Medical research Metabolism Pathology Proteins Spectral analysis Stable isotopes Syndrome Zinc Zinc - blood Zinc - metabolism |
| title | Hyperzincaemia and hypercalprotectinaemia: a new disorder of zinc metabolism |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T05%3A50%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hyperzincaemia%20and%20hypercalprotectinaemia:%20a%20new%20disorder%20of%20zinc%20metabolism&rft.jtitle=The%20Lancet%20(British%20edition)&rft.au=Sampson,%20Barry&rft.date=2002-11-30&rft.volume=360&rft.issue=9347&rft.spage=1742&rft.epage=1745&rft.pages=1742-1745&rft.issn=0140-6736&rft.eissn=1474-547X&rft.coden=LANCAO&rft_id=info:doi/10.1016/S0140-6736(02)11683-7&rft_dat=%3Cproquest_cross%3E72773877%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=199085681&rft_id=info:pmid/12480428&rft_els_id=S0140673602116837&rfr_iscdi=true |