β-Arrestin 1 Couples Thrombin to the Rapid Activation of the Akt Pathway

: In a variety of cell types including chinese hamster embryonic fibroblasts (IIC9 cells), α‐thrombin is a potent mitogen. Thrombin irreversibly activates Par 1, a member of the seven membrane‐spanning superfamily of G protein‐coupled receptors (GPCRs). This, in turn, activates several heterotrimeri...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2002-11, Vol.973 (1), p.138-141
Hauptverfasser:	GOEL, REEMA, BALDASSARE, JOSEPH J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt pathway Animals Arrestins - physiology beta-Arrestin 1 beta-Arrestins Cell Line Humans Kinetics MAP Kinase Signaling System - physiology Protein Transport Protein-Serine-Threonine Kinases Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Thrombin - physiology α-thrombin β-arrestin 1
Online-Zugang:	Volltext
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