Debrisoquine polymorphism: novel CYP2D6 gene Bam HI restriction fragment length polymorphism in the Ngawbé Guaymí Indian of Panama

Markedly decreased cytochrome P450-mediated metabolism of debrisoquine, sparteine, and more than two dozen additional commonly prescribed drugs is an autosomal recessive trait that has been associated with several RFLP patterns involving the CYP2D6 gene. In Caucasians there are at least six variant...

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Veröffentlicht in:	Pharmacogenetics (London) 1991-12, Vol.1 (3), p.136-142
Hauptverfasser:	Petersen, D D, Kong, A N, Jorge, L F, Nebert, D W, Arias, T D
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Biological Evolution Cytochrome P-450 CYP2D6 Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism Debrisoquin - metabolism Female Humans Indians, Central American - genetics Male Mixed Function Oxygenases - genetics Mixed Function Oxygenases - metabolism Panama Pedigree Phenotype Polymorphism, Restriction Fragment Length Pseudogenes Sparteine - metabolism
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