Aberrant Promoter Methylation in Chinese Patients with Non-Small Cell Lung Cancer: Patterns in Primary Tumors and Potential Diagnostic Application in Bronchoalevolar Lavage

This study was aimed at defining patterns of aberrant gene methylation in non-small cell lung cancer (NSCLC) in Chinese patients and its use in detecting cancer cells in bronchoalveolar lavage (BAL). The methylation-specific PCR (MSP) was used to study methylation of the p16 , retinoic acid receptor...

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Veröffentlicht in:	Clinical cancer research 2002-12, Vol.8 (12), p.3741-3746
Hauptverfasser:	CHAN, Eunice C, LAM, Shui Y, TSANG, Kenneth W, LAM, Bing, HO, James C. M, FU, Kin H, LAM, Wah K, KWONG, Yok L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Apoptosis Regulatory Proteins Biological and medical sciences Bronchoalveolar Lavage Calcium-Calmodulin-Dependent Protein Kinases - genetics Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Squamous Cell - genetics China - epidemiology Cyclin-Dependent Kinase Inhibitor p16 - genetics Death-Associated Protein Kinases DNA Methylation DNA, Neoplasm - metabolism Female Gene Expression Regulation, Neoplastic Gene Silencing Humans Lung Neoplasms - genetics Male Medical sciences O-Methylguanine-DNA Methyltransferase - genetics Pneumology Polymerase Chain Reaction - methods Promoter Regions, Genetic - genetics Prospective Studies Receptors, Retinoic Acid - genetics Risk Factors Sensitivity and Specificity Survival Rate Tumors of the respiratory system and mediastinum
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