Antioxidant status during cutaneous wound healing in immunocompromised rats
The present investigation was undertaken to investigate the endogenous status of free radical scavengers during cutaneous wound healing in immunocompromised rats. Antioxidant contents and lipid peroxidation product in terms of malondialdehyde (MDA) have been monitored in the wound tissues of immunos...
Gespeichert in:
| Veröffentlicht in: | Molecular and cellular biochemistry 2002-12, Vol.241 (1-2), p.1-7 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 7 |
|---|---|
| container_issue | 1-2 |
| container_start_page | 1 |
| container_title | Molecular and cellular biochemistry |
| container_volume | 241 |
| creator | Gupta, Asheesh Singh, Ram L Raghubir, Ram |
| description | The present investigation was undertaken to investigate the endogenous status of free radical scavengers during cutaneous wound healing in immunocompromised rats. Antioxidant contents and lipid peroxidation product in terms of malondialdehyde (MDA) have been monitored in the wound tissues of immunosuppressed rats at different time intervals (2, 7 and 14 days) following cutaneous injury. A significant increase in MDA content and decrease in glutathione and vitamin C content was observed in the skin of immunocompromised rats as compared to control subjects. Further, a significant decrease in vitamin C, vitamin E content, catalase and glutathione peroxidase activity was observed at 2 days postwounding in immunocompromised rats. A significant and time-dependent decrease in glutathione content was also observed at 7 and 14 days postwounding. However, the healing tissue on 2 and 7 days postwounding exhibited significantly elevated superoxide dismutase activity. The MDA content was augmented only at 2 days postwounding in immunosuppressed rats. Thus significant alterations in the antioxidant profile accompanied by elevated levels of MDA, a marker of free radical damage may be contributory to impaired wound healing in immunocompromised rats. |
| doi_str_mv | 10.1023/a:1020804916733 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_72769074</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2153377251</sourcerecordid><originalsourceid>FETCH-LOGICAL-c346t-e8d8529d9ec4438c5652a1e5237ec2dea0543cf207b6aa577550bb46c1ec6acb3</originalsourceid><addsrcrecordid>eNpdkEtLAzEUhYMotlbX7mRw4W4070zcleILC250PWSSVFNmkjpJsP57I60b4cLhHj7uPRwAzhG8RhCTG3VbBDaQSsQFIQdgipggdVnlIZhCAmHdICEm4CTGNYSoDDoGE4RpgyGSU_A898mFrTPKpyomlXKsTB6df690TsrbUIyvkL2pPqzqf33nKzcM2Qcdhs0YBhetqUaV4ik4Wqk-2rO9zsDb_d3r4rFevjw8LebLWhPKU20b0zAsjbSaUtJoxhlWyDJMhNXYWAUZJXqFoei4UkwIxmDXUa6R1VzpjszA1e5u-f6ZbUxtyaBt3-_itgILLqGgBbz8B65DHn3J1grGMSUUyQJd7KHcDda0m9ENavxu_zoiP21IaTw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>756243419</pqid></control><display><type>article</type><title>Antioxidant status during cutaneous wound healing in immunocompromised rats</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Gupta, Asheesh ; Singh, Ram L ; Raghubir, Ram</creator><creatorcontrib>Gupta, Asheesh ; Singh, Ram L ; Raghubir, Ram</creatorcontrib><description>The present investigation was undertaken to investigate the endogenous status of free radical scavengers during cutaneous wound healing in immunocompromised rats. Antioxidant contents and lipid peroxidation product in terms of malondialdehyde (MDA) have been monitored in the wound tissues of immunosuppressed rats at different time intervals (2, 7 and 14 days) following cutaneous injury. A significant increase in MDA content and decrease in glutathione and vitamin C content was observed in the skin of immunocompromised rats as compared to control subjects. Further, a significant decrease in vitamin C, vitamin E content, catalase and glutathione peroxidase activity was observed at 2 days postwounding in immunocompromised rats. A significant and time-dependent decrease in glutathione content was also observed at 7 and 14 days postwounding. However, the healing tissue on 2 and 7 days postwounding exhibited significantly elevated superoxide dismutase activity. The MDA content was augmented only at 2 days postwounding in immunosuppressed rats. Thus significant alterations in the antioxidant profile accompanied by elevated levels of MDA, a marker of free radical damage may be contributory to impaired wound healing in immunocompromised rats.</description><identifier>ISSN: 0300-8177</identifier><identifier>EISSN: 1573-4919</identifier><identifier>DOI: 10.1023/a:1020804916733</identifier><identifier>PMID: 12482019</identifier><language>eng</language><publisher>Netherlands: Springer Nature B.V</publisher><subject>Animals ; Antioxidants ; Antioxidants - metabolism ; Immunocompromised Host ; Lipid Peroxidation ; Male ; Malondialdehyde - metabolism ; Nutrition ; Peroxidation ; Rats ; Rats, Sprague-Dawley ; Rodents ; Thiobarbituric Acid Reactive Substances ; Wound Healing</subject><ispartof>Molecular and cellular biochemistry, 2002-12, Vol.241 (1-2), p.1-7</ispartof><rights>Kluwer Academic Publishers 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c346t-e8d8529d9ec4438c5652a1e5237ec2dea0543cf207b6aa577550bb46c1ec6acb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12482019$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gupta, Asheesh</creatorcontrib><creatorcontrib>Singh, Ram L</creatorcontrib><creatorcontrib>Raghubir, Ram</creatorcontrib><title>Antioxidant status during cutaneous wound healing in immunocompromised rats</title><title>Molecular and cellular biochemistry</title><addtitle>Mol Cell Biochem</addtitle><description>The present investigation was undertaken to investigate the endogenous status of free radical scavengers during cutaneous wound healing in immunocompromised rats. Antioxidant contents and lipid peroxidation product in terms of malondialdehyde (MDA) have been monitored in the wound tissues of immunosuppressed rats at different time intervals (2, 7 and 14 days) following cutaneous injury. A significant increase in MDA content and decrease in glutathione and vitamin C content was observed in the skin of immunocompromised rats as compared to control subjects. Further, a significant decrease in vitamin C, vitamin E content, catalase and glutathione peroxidase activity was observed at 2 days postwounding in immunocompromised rats. A significant and time-dependent decrease in glutathione content was also observed at 7 and 14 days postwounding. However, the healing tissue on 2 and 7 days postwounding exhibited significantly elevated superoxide dismutase activity. The MDA content was augmented only at 2 days postwounding in immunosuppressed rats. Thus significant alterations in the antioxidant profile accompanied by elevated levels of MDA, a marker of free radical damage may be contributory to impaired wound healing in immunocompromised rats.</description><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>Immunocompromised Host</subject><subject>Lipid Peroxidation</subject><subject>Male</subject><subject>Malondialdehyde - metabolism</subject><subject>Nutrition</subject><subject>Peroxidation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rodents</subject><subject>Thiobarbituric Acid Reactive Substances</subject><subject>Wound Healing</subject><issn>0300-8177</issn><issn>1573-4919</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkEtLAzEUhYMotlbX7mRw4W4070zcleILC250PWSSVFNmkjpJsP57I60b4cLhHj7uPRwAzhG8RhCTG3VbBDaQSsQFIQdgipggdVnlIZhCAmHdICEm4CTGNYSoDDoGE4RpgyGSU_A898mFrTPKpyomlXKsTB6df690TsrbUIyvkL2pPqzqf33nKzcM2Qcdhs0YBhetqUaV4ik4Wqk-2rO9zsDb_d3r4rFevjw8LebLWhPKU20b0zAsjbSaUtJoxhlWyDJMhNXYWAUZJXqFoei4UkwIxmDXUa6R1VzpjszA1e5u-f6ZbUxtyaBt3-_itgILLqGgBbz8B65DHn3J1grGMSUUyQJd7KHcDda0m9ENavxu_zoiP21IaTw</recordid><startdate>20021201</startdate><enddate>20021201</enddate><creator>Gupta, Asheesh</creator><creator>Singh, Ram L</creator><creator>Raghubir, Ram</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20021201</creationdate><title>Antioxidant status during cutaneous wound healing in immunocompromised rats</title><author>Gupta, Asheesh ; Singh, Ram L ; Raghubir, Ram</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c346t-e8d8529d9ec4438c5652a1e5237ec2dea0543cf207b6aa577550bb46c1ec6acb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Antioxidants</topic><topic>Antioxidants - metabolism</topic><topic>Immunocompromised Host</topic><topic>Lipid Peroxidation</topic><topic>Male</topic><topic>Malondialdehyde - metabolism</topic><topic>Nutrition</topic><topic>Peroxidation</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Rodents</topic><topic>Thiobarbituric Acid Reactive Substances</topic><topic>Wound Healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gupta, Asheesh</creatorcontrib><creatorcontrib>Singh, Ram L</creatorcontrib><creatorcontrib>Raghubir, Ram</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular and cellular biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gupta, Asheesh</au><au>Singh, Ram L</au><au>Raghubir, Ram</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antioxidant status during cutaneous wound healing in immunocompromised rats</atitle><jtitle>Molecular and cellular biochemistry</jtitle><addtitle>Mol Cell Biochem</addtitle><date>2002-12-01</date><risdate>2002</risdate><volume>241</volume><issue>1-2</issue><spage>1</spage><epage>7</epage><pages>1-7</pages><issn>0300-8177</issn><eissn>1573-4919</eissn><abstract>The present investigation was undertaken to investigate the endogenous status of free radical scavengers during cutaneous wound healing in immunocompromised rats. Antioxidant contents and lipid peroxidation product in terms of malondialdehyde (MDA) have been monitored in the wound tissues of immunosuppressed rats at different time intervals (2, 7 and 14 days) following cutaneous injury. A significant increase in MDA content and decrease in glutathione and vitamin C content was observed in the skin of immunocompromised rats as compared to control subjects. Further, a significant decrease in vitamin C, vitamin E content, catalase and glutathione peroxidase activity was observed at 2 days postwounding in immunocompromised rats. A significant and time-dependent decrease in glutathione content was also observed at 7 and 14 days postwounding. However, the healing tissue on 2 and 7 days postwounding exhibited significantly elevated superoxide dismutase activity. The MDA content was augmented only at 2 days postwounding in immunosuppressed rats. Thus significant alterations in the antioxidant profile accompanied by elevated levels of MDA, a marker of free radical damage may be contributory to impaired wound healing in immunocompromised rats.</abstract><cop>Netherlands</cop><pub>Springer Nature B.V</pub><pmid>12482019</pmid><doi>10.1023/a:1020804916733</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-8177 |
| ispartof | Molecular and cellular biochemistry, 2002-12, Vol.241 (1-2), p.1-7 |
| issn | 0300-8177 1573-4919 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72769074 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Antioxidants Antioxidants - metabolism Immunocompromised Host Lipid Peroxidation Male Malondialdehyde - metabolism Nutrition Peroxidation Rats Rats, Sprague-Dawley Rodents Thiobarbituric Acid Reactive Substances Wound Healing |
| title | Antioxidant status during cutaneous wound healing in immunocompromised rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T07%3A09%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Antioxidant%20status%20during%20cutaneous%20wound%20healing%20in%20immunocompromised%20rats&rft.jtitle=Molecular%20and%20cellular%20biochemistry&rft.au=Gupta,%20Asheesh&rft.date=2002-12-01&rft.volume=241&rft.issue=1-2&rft.spage=1&rft.epage=7&rft.pages=1-7&rft.issn=0300-8177&rft.eissn=1573-4919&rft_id=info:doi/10.1023/a:1020804916733&rft_dat=%3Cproquest_pubme%3E2153377251%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=756243419&rft_id=info:pmid/12482019&rfr_iscdi=true |