IGF-2 Is a Mediator of Prolactin-Induced Morphogenesis in the Breast

The mechanisms by which prolactin controls proliferation of mammary epithelial cells (MECs) and morphogenesis of the breast epithelium are poorly understood. We show that cyclin D1 −/− MECs fail to proliferate in response to prolactin and identify IGF-2 as a downstream target of prolactin signaling...

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Veröffentlicht in:	Developmental cell 2002-12, Vol.3 (6), p.877-887
Hauptverfasser:	Brisken, Cathrin, Ayyannan, Ayyakkannu, Nguyen, Cuc, Heineman, Anna, Reinhardt, Ferenc, Jan, Tian, Dey, S.K., Dotto, G.Paolo, Weinberg, Robert A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Breast Neoplasms - genetics Carcinoma - genetics Carrier Proteins Cell Division - genetics Cells, Cultured Cyclin D1 - deficiency Cyclin D1 - genetics Epithelial Cells - cytology Epithelial Cells - drug effects Epithelial Cells - metabolism Female Gene Expression Regulation, Developmental - genetics Genes - drug effects Genes - genetics Genetic Testing Insulin-Like Growth Factor II - genetics Insulin-Like Growth Factor II - metabolism Mammary Glands, Animal - cytology Mammary Glands, Animal - embryology Mammary Glands, Animal - metabolism Membrane Glycoproteins Mice Mice, Knockout Oligonucleotide Array Sequence Analysis Progesterone - metabolism Progesterone - pharmacology Prolactin - genetics Prolactin - metabolism Prolactin - pharmacology RANK Ligand Receptor Activator of Nuclear Factor-kappa B Receptors, Progesterone - deficiency Receptors, Progesterone - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction - genetics
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