From Extracellular to Intracellular Targets, Inhibiting MAP Kinases in Treatment of Crohn's Disease

: In recent years the emphasis in finding new therapeutic options for chronic inflammatory diseases has been on targeting extracellular mediators of inflammation. A range of tools has become available to interfere with signaling by cytokines and their receptors. As our understanding of the intracell...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2002-11, Vol.973 (1), p.349-358
Hauptverfasser:	VAN DEN BLINK, BERNT, ten HOVE, TESSA, VAN DEN BRINK, GIJS R., PEPPELENBOSCH, MAIKEL P., VAN DEVENTER, SANDER J.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Crohn Disease - drug therapy Crohn Disease - enzymology Crohn's disease cytokines Enzyme Inhibitors - therapeutic use Extracellular Space - physiology human Humans inflammation Interferon-gamma - biosynthesis Interleukin-12 - physiology Interleukin-18 - physiology Intracellular Fluid - physiology MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - physiology mitogen-activated protein kinases Mitogen-Activated Protein Kinases - antagonists & inhibitors Models, Biological Th1/Th2 cells therapy Tumor Necrosis Factor-alpha - physiology
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