Detection of capsular polysaccharide antigen of Cryptococcus neoformans in patients with AIDS and neurocryptococcosis in São Paulo, Brazil
Capsular polysaccharide antigen (AgPC) of Cryptococcus neoformans was detected by latex agglutination technique (LA) in cerebrospinal fluid and serum of patients with AIDS during their first central nervous system manifestation of the disease. Direct mycological examination and culture were used as...
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| Veröffentlicht in: | Revista do Instituto de Medicina Tropical de São Paulo 1991-11, Vol.33 (6), p.485-490 |
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| container_title | Revista do Instituto de Medicina Tropical de São Paulo |
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| creator | Calvo, B Fischman, O Castelo Filho, A Reis Filho, J Del Bianco, R Barbosa, R M Zaror, L |
| description | Capsular polysaccharide antigen (AgPC) of Cryptococcus neoformans was detected by latex agglutination technique (LA) in cerebrospinal fluid and serum of patients with AIDS during their first central nervous system manifestation of the disease. Direct mycological examination and culture were used as controls. Sensitivity was 100% by LA allowing an early specific treatment of cryptococcosis. Initial titres of AgPC in such patients can be > 1000000 and it appears that when such titres are present in the serum they are related to mortality during treatment. Surviving patients showed positivity of the direct mycological examination and AgPC of C. neoformans in cerebrospinal fluid and sera even after treatment and clinical recovery. |
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Direct mycological examination and culture were used as controls. Sensitivity was 100% by LA allowing an early specific treatment of cryptococcosis. Initial titres of AgPC in such patients can be > 1000000 and it appears that when such titres are present in the serum they are related to mortality during treatment. 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Direct mycological examination and culture were used as controls. Sensitivity was 100% by LA allowing an early specific treatment of cryptococcosis. Initial titres of AgPC in such patients can be > 1000000 and it appears that when such titres are present in the serum they are related to mortality during treatment. Surviving patients showed positivity of the direct mycological examination and AgPC of C. neoformans in cerebrospinal fluid and sera even after treatment and clinical recovery.</description><subject>Acquired Immunodeficiency Syndrome - immunology</subject><subject>Acquired Immunodeficiency Syndrome - mortality</subject><subject>Adolescent</subject><subject>Adult</subject><subject>AIDS/HIV</subject><subject>Antigens, Bacterial - isolation & purification</subject><subject>Brain Diseases - immunology</subject><subject>Brain Diseases - mortality</subject><subject>Brazil</subject><subject>Cryptococcosis - immunology</subject><subject>Cryptococcosis - mortality</subject><subject>Cryptococcus neoformans - immunology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polysaccharides - immunology</subject><issn>0036-4665</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo90E1OwzAQBWAvQKUUjoDkFSsiOYnjn2VpoVSqBFK7jya2Q42SONiOULkCx-AoXIyoVKxmMd970swZmhKSs4QyVlygyxDeCCGSSDZBk1RQKrmcoq-liUZF6zrsaqygD0MDHveuOQRQag_eaoOhi_bVHMnCH_rolFNqCLgzrna-hS5g2-EeojVdDPjDxj2er5fbMahHNHin_mMu2KPe_nw7_AJD4-7wvYdP21yh8xqaYK5Pc4Z2jw-7xVOyeV6tF_NN0he5TFLNKFRU6IxxKaoUQABRoMFIneWUFllRURCM8yoXGjKm1LipBZdKSVJk-Qzd_tX23r0PJsSytUGZpoHxnCGUPOOsIDQd4c0JDlVrdNl724I_lKfn5b80dG4c</recordid><startdate>199111</startdate><enddate>199111</enddate><creator>Calvo, B</creator><creator>Fischman, O</creator><creator>Castelo Filho, A</creator><creator>Reis Filho, J</creator><creator>Del Bianco, R</creator><creator>Barbosa, R M</creator><creator>Zaror, L</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199111</creationdate><title>Detection of capsular polysaccharide antigen of Cryptococcus neoformans in patients with AIDS and neurocryptococcosis in São Paulo, Brazil</title><author>Calvo, B ; Fischman, O ; Castelo Filho, A ; Reis Filho, J ; Del Bianco, R ; Barbosa, R M ; Zaror, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p539-1d64ab48d26798b1aa8a0cadae9d2344525b4a8677b38da26cce9df879cc90523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>spa</language><creationdate>1991</creationdate><topic>Acquired Immunodeficiency Syndrome - immunology</topic><topic>Acquired Immunodeficiency Syndrome - mortality</topic><topic>Adolescent</topic><topic>Adult</topic><topic>AIDS/HIV</topic><topic>Antigens, Bacterial - isolation & purification</topic><topic>Brain Diseases - immunology</topic><topic>Brain Diseases - mortality</topic><topic>Brazil</topic><topic>Cryptococcosis - immunology</topic><topic>Cryptococcosis - mortality</topic><topic>Cryptococcus neoformans - immunology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Polysaccharides - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Calvo, B</creatorcontrib><creatorcontrib>Fischman, O</creatorcontrib><creatorcontrib>Castelo Filho, A</creatorcontrib><creatorcontrib>Reis Filho, J</creatorcontrib><creatorcontrib>Del Bianco, R</creatorcontrib><creatorcontrib>Barbosa, R M</creatorcontrib><creatorcontrib>Zaror, L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Revista do Instituto de Medicina Tropical de São Paulo</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Calvo, B</au><au>Fischman, O</au><au>Castelo Filho, A</au><au>Reis Filho, J</au><au>Del Bianco, R</au><au>Barbosa, R M</au><au>Zaror, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detection of capsular polysaccharide antigen of Cryptococcus neoformans in patients with AIDS and neurocryptococcosis in São Paulo, Brazil</atitle><jtitle>Revista do Instituto de Medicina Tropical de São Paulo</jtitle><addtitle>Rev Inst Med Trop Sao Paulo</addtitle><date>1991-11</date><risdate>1991</risdate><volume>33</volume><issue>6</issue><spage>485</spage><epage>490</epage><pages>485-490</pages><issn>0036-4665</issn><abstract>Capsular polysaccharide antigen (AgPC) of Cryptococcus neoformans was detected by latex agglutination technique (LA) in cerebrospinal fluid and serum of patients with AIDS during their first central nervous system manifestation of the disease. 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| identifier | ISSN: 0036-4665 |
| ispartof | Revista do Instituto de Medicina Tropical de São Paulo, 1991-11, Vol.33 (6), p.485-490 |
| issn | 0036-4665 |
| language | spa |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Acquired Immunodeficiency Syndrome - immunology Acquired Immunodeficiency Syndrome - mortality Adolescent Adult AIDS/HIV Antigens, Bacterial - isolation & purification Brain Diseases - immunology Brain Diseases - mortality Brazil Cryptococcosis - immunology Cryptococcosis - mortality Cryptococcus neoformans - immunology Female Humans Male Middle Aged Polysaccharides - immunology |
| title | Detection of capsular polysaccharide antigen of Cryptococcus neoformans in patients with AIDS and neurocryptococcosis in São Paulo, Brazil |
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