Role of cell surface GM3 ganglioside and sialic acid in the antitumor activity of a GM3-based vaccine in the murine B16 melanoma model

To examine the role of GM3 monosialoganglioside and sialic acid in the antitumor activity of a vaccine based on GM3, hydrophobically conjugated with the outer-membrane-protein complex from Neisseria meningitidis (GM3/VSSP). In order to evaluate the relationship between antitumor activity and the pre...

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Veröffentlicht in:	Journal of cancer research and clinical oncology 2002-12, Vol.128 (12), p.669-677
Hauptverfasser:	GABRI, Mariano R, RIPOLL, Giselle V, ALONSO, Daniel F, GOMEZ, Daniel E
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Animals Antineoplastic agents Bacterial Outer Membrane Proteins - immunology Biological and medical sciences Cancer Vaccines - therapeutic use Cell Division - drug effects Cell Membrane - immunology Cells Disease Models, Animal Enzyme-Linked Immunosorbent Assay Female Flow Cytometry G(M3) Ganglioside - immunology G(M3) Ganglioside - pharmacology Immunoglobulin G - therapeutic use Immunoglobulin M - therapeutic use Immunotherapy Mammary Neoplasms, Experimental - immunology Mammary Neoplasms, Experimental - therapy Medical sciences Melanoma, Experimental - immunology Melanoma, Experimental - pathology Melanoma, Experimental - therapy Mice Mice, Inbred C57BL N-Acetylneuraminic Acid - immunology Neisseria meningitidis - immunology Pharmacology. Drug treatments Tumors Vaccines
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