IgM Antibody Response in Acute Hepatitis C Viral Infection
IgM antibody against hepatitis C virus (IgM anti-HCV) was measured in serial samples from 15 transfusion recipients in whom posttransfusion chronic non-A, non-B hepatitis (NANBH) developed and three plasmapheresis donors during acute HCV infection using recombinant proteins derived from three immuno...
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| Veröffentlicht in: | Blood 1992-01, Vol.79 (1), p.169-172 |
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| creator | Clemens, John M. Taskar, Suhas Chau, Kurt Vallari, David Shih, J. Wai-Kuo Alter, Harvey J. Schleicher, Joseph B. Mimms, Larry T. |
| description | IgM antibody against hepatitis C virus (IgM anti-HCV) was measured in serial samples from 15 transfusion recipients in whom posttransfusion chronic non-A, non-B hepatitis (NANBH) developed and three plasmapheresis donors during acute HCV infection using recombinant proteins derived from three immunodominant regions: core, NS-3, and NS-4 (c100). IgM anti-HCV core was detected in 13 of 15 posttrans-fusion patients. Nine of these patients had transient, acute-phase IgM anti-HCV core detected coincidentally or earlier than active IgG anti-HCV core response. The average dura- tion of IgM anti-HCV core reactivity was 8.1 ± 3.7 weeks. One patient lacking an IgM anti-HCV core response had detectable IgM anti-HCV NS-3 during the acute phase. Passive transfer of IgM anti-HCV was not observed in these posttrans-fusion cases, in contrast to the high frequency observed for IgG anti-HCV. Late IgM anti-HCV was detectable against core, c100, and NS-3 in three, two, and one posttransfusion patients, respectively. These data indicate that IgM anti-HCV core is a useful acute-phase marker in HCV infection.© 1992 by The American Society of Hematology. 0006–4971/92/7901-0030$3.00/0 |
| doi_str_mv | 10.1182/blood.V79.1.169.169 |
| format | Article |
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Wai-Kuo ; Alter, Harvey J. ; Schleicher, Joseph B. ; Mimms, Larry T.</creator><creatorcontrib>Clemens, John M. ; Taskar, Suhas ; Chau, Kurt ; Vallari, David ; Shih, J. Wai-Kuo ; Alter, Harvey J. ; Schleicher, Joseph B. ; Mimms, Larry T.</creatorcontrib><description>IgM antibody against hepatitis C virus (IgM anti-HCV) was measured in serial samples from 15 transfusion recipients in whom posttransfusion chronic non-A, non-B hepatitis (NANBH) developed and three plasmapheresis donors during acute HCV infection using recombinant proteins derived from three immunodominant regions: core, NS-3, and NS-4 (c100). IgM anti-HCV core was detected in 13 of 15 posttrans-fusion patients. Nine of these patients had transient, acute-phase IgM anti-HCV core detected coincidentally or earlier than active IgG anti-HCV core response. The average dura- tion of IgM anti-HCV core reactivity was 8.1 ± 3.7 weeks. One patient lacking an IgM anti-HCV core response had detectable IgM anti-HCV NS-3 during the acute phase. Passive transfer of IgM anti-HCV was not observed in these posttrans-fusion cases, in contrast to the high frequency observed for IgG anti-HCV. Late IgM anti-HCV was detectable against core, c100, and NS-3 in three, two, and one posttransfusion patients, respectively. These data indicate that IgM anti-HCV core is a useful acute-phase marker in HCV infection.© 1992 by The American Society of Hematology. 0006–4971/92/7901-0030$3.00/0</description><identifier>ISSN: 0006-4971</identifier><identifier>EISSN: 1528-0020</identifier><identifier>DOI: 10.1182/blood.V79.1.169.169</identifier><identifier>PMID: 1309424</identifier><language>eng</language><publisher>Washington, DC: Elsevier Inc</publisher><subject>Antigens, Viral - immunology ; Biological and medical sciences ; Blood Donors ; Blood Transfusion ; Hepacivirus - immunology ; Hepatitis Antibodies - blood ; Hepatitis C - immunology ; Hepatitis C - transmission ; hepatitis C virus ; Human viral diseases ; Humans ; Immunization, Passive ; Immunoglobulin G - blood ; Immunoglobulin M - blood ; Infectious diseases ; Medical sciences ; Plasmapheresis ; Prospective Studies ; Viral Core Proteins - immunology ; Viral diseases ; Viral diseases of the digestive system ; Viral Nonstructural Proteins - immunology</subject><ispartof>Blood, 1992-01, Vol.79 (1), p.169-172</ispartof><rights>1992 American Society of Hematology</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3749-738dab406db80622ca6a5583d810c8a3bc132f2549d690b6be230f001e192b83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,4025,27928,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5139553$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1309424$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Clemens, John M.</creatorcontrib><creatorcontrib>Taskar, Suhas</creatorcontrib><creatorcontrib>Chau, Kurt</creatorcontrib><creatorcontrib>Vallari, David</creatorcontrib><creatorcontrib>Shih, J. Wai-Kuo</creatorcontrib><creatorcontrib>Alter, Harvey J.</creatorcontrib><creatorcontrib>Schleicher, Joseph B.</creatorcontrib><creatorcontrib>Mimms, Larry T.</creatorcontrib><title>IgM Antibody Response in Acute Hepatitis C Viral Infection</title><title>Blood</title><addtitle>Blood</addtitle><description>IgM antibody against hepatitis C virus (IgM anti-HCV) was measured in serial samples from 15 transfusion recipients in whom posttransfusion chronic non-A, non-B hepatitis (NANBH) developed and three plasmapheresis donors during acute HCV infection using recombinant proteins derived from three immunodominant regions: core, NS-3, and NS-4 (c100). IgM anti-HCV core was detected in 13 of 15 posttrans-fusion patients. Nine of these patients had transient, acute-phase IgM anti-HCV core detected coincidentally or earlier than active IgG anti-HCV core response. The average dura- tion of IgM anti-HCV core reactivity was 8.1 ± 3.7 weeks. One patient lacking an IgM anti-HCV core response had detectable IgM anti-HCV NS-3 during the acute phase. Passive transfer of IgM anti-HCV was not observed in these posttrans-fusion cases, in contrast to the high frequency observed for IgG anti-HCV. Late IgM anti-HCV was detectable against core, c100, and NS-3 in three, two, and one posttransfusion patients, respectively. These data indicate that IgM anti-HCV core is a useful acute-phase marker in HCV infection.© 1992 by The American Society of Hematology. 0006–4971/92/7901-0030$3.00/0</description><subject>Antigens, Viral - immunology</subject><subject>Biological and medical sciences</subject><subject>Blood Donors</subject><subject>Blood Transfusion</subject><subject>Hepacivirus - immunology</subject><subject>Hepatitis Antibodies - blood</subject><subject>Hepatitis C - immunology</subject><subject>Hepatitis C - transmission</subject><subject>hepatitis C virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunization, Passive</subject><subject>Immunoglobulin G - blood</subject><subject>Immunoglobulin M - blood</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Plasmapheresis</subject><subject>Prospective Studies</subject><subject>Viral Core Proteins - immunology</subject><subject>Viral diseases</subject><subject>Viral diseases of the digestive system</subject><subject>Viral Nonstructural Proteins - immunology</subject><issn>0006-4971</issn><issn>1528-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1rGzEQhkVpSN0kv6AE9lB6W3dGWu2uCj0Y0zaGhEIJuQp9zBaV9cqV1oX8-8q1SW7pYZjDPO_L8DD2DmGJ2POPdozRLx86tcQltuowr9gCJe9rAA6v2QIA2rpRHb5hb3P-BYCN4PKcnaMA1fBmwT5tft5Vq2kONvrH6gflXZwyVWGqVm4_U3VDOzOHOeRqXT2EZMZqMw3k5hCnS3Y2mDHT1WlfsPuvX-7XN_Xt92-b9eq2dqJrVN2J3hvbQOttDy3nzrRGyl74HsH1RliHgg9cNsq3CmxriQsYyquEitteXLAPx9pdir_3lGe9DdnROJqJ4j7rjnelFeG_ILay6wpZQHEEXYo5Jxr0LoWtSY8aQR_M6n9mdTGrscTUYUrq-lS_t1vyz5mjynJ_f7qb7Mw4JDO5kJ8wiUJJKQr2-YhRUfYnUNLZBZoc-ZCKV-1jePGNv6CBlI8</recordid><startdate>19920101</startdate><enddate>19920101</enddate><creator>Clemens, John M.</creator><creator>Taskar, Suhas</creator><creator>Chau, Kurt</creator><creator>Vallari, David</creator><creator>Shih, J. Wai-Kuo</creator><creator>Alter, Harvey J.</creator><creator>Schleicher, Joseph B.</creator><creator>Mimms, Larry T.</creator><general>Elsevier Inc</general><general>The Americain Society of Hematology</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19920101</creationdate><title>IgM Antibody Response in Acute Hepatitis C Viral Infection</title><author>Clemens, John M. ; Taskar, Suhas ; Chau, Kurt ; Vallari, David ; Shih, J. Wai-Kuo ; Alter, Harvey J. ; Schleicher, Joseph B. ; Mimms, Larry T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3749-738dab406db80622ca6a5583d810c8a3bc132f2549d690b6be230f001e192b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Antigens, Viral - immunology</topic><topic>Biological and medical sciences</topic><topic>Blood Donors</topic><topic>Blood Transfusion</topic><topic>Hepacivirus - immunology</topic><topic>Hepatitis Antibodies - blood</topic><topic>Hepatitis C - immunology</topic><topic>Hepatitis C - transmission</topic><topic>hepatitis C virus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunization, Passive</topic><topic>Immunoglobulin G - blood</topic><topic>Immunoglobulin M - blood</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Plasmapheresis</topic><topic>Prospective Studies</topic><topic>Viral Core Proteins - immunology</topic><topic>Viral diseases</topic><topic>Viral diseases of the digestive system</topic><topic>Viral Nonstructural Proteins - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Clemens, John M.</creatorcontrib><creatorcontrib>Taskar, Suhas</creatorcontrib><creatorcontrib>Chau, Kurt</creatorcontrib><creatorcontrib>Vallari, David</creatorcontrib><creatorcontrib>Shih, J. Wai-Kuo</creatorcontrib><creatorcontrib>Alter, Harvey J.</creatorcontrib><creatorcontrib>Schleicher, Joseph B.</creatorcontrib><creatorcontrib>Mimms, Larry T.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Blood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Clemens, John M.</au><au>Taskar, Suhas</au><au>Chau, Kurt</au><au>Vallari, David</au><au>Shih, J. Wai-Kuo</au><au>Alter, Harvey J.</au><au>Schleicher, Joseph B.</au><au>Mimms, Larry T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IgM Antibody Response in Acute Hepatitis C Viral Infection</atitle><jtitle>Blood</jtitle><addtitle>Blood</addtitle><date>1992-01-01</date><risdate>1992</risdate><volume>79</volume><issue>1</issue><spage>169</spage><epage>172</epage><pages>169-172</pages><issn>0006-4971</issn><eissn>1528-0020</eissn><abstract>IgM antibody against hepatitis C virus (IgM anti-HCV) was measured in serial samples from 15 transfusion recipients in whom posttransfusion chronic non-A, non-B hepatitis (NANBH) developed and three plasmapheresis donors during acute HCV infection using recombinant proteins derived from three immunodominant regions: core, NS-3, and NS-4 (c100). IgM anti-HCV core was detected in 13 of 15 posttrans-fusion patients. Nine of these patients had transient, acute-phase IgM anti-HCV core detected coincidentally or earlier than active IgG anti-HCV core response. The average dura- tion of IgM anti-HCV core reactivity was 8.1 ± 3.7 weeks. One patient lacking an IgM anti-HCV core response had detectable IgM anti-HCV NS-3 during the acute phase. Passive transfer of IgM anti-HCV was not observed in these posttrans-fusion cases, in contrast to the high frequency observed for IgG anti-HCV. Late IgM anti-HCV was detectable against core, c100, and NS-3 in three, two, and one posttransfusion patients, respectively. These data indicate that IgM anti-HCV core is a useful acute-phase marker in HCV infection.© 1992 by The American Society of Hematology. 0006–4971/92/7901-0030$3.00/0</abstract><cop>Washington, DC</cop><pub>Elsevier Inc</pub><pmid>1309424</pmid><doi>10.1182/blood.V79.1.169.169</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Antigens, Viral - immunology Biological and medical sciences Blood Donors Blood Transfusion Hepacivirus - immunology Hepatitis Antibodies - blood Hepatitis C - immunology Hepatitis C - transmission hepatitis C virus Human viral diseases Humans Immunization, Passive Immunoglobulin G - blood Immunoglobulin M - blood Infectious diseases Medical sciences Plasmapheresis Prospective Studies Viral Core Proteins - immunology Viral diseases Viral diseases of the digestive system Viral Nonstructural Proteins - immunology |
| title | IgM Antibody Response in Acute Hepatitis C Viral Infection |
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