Exacerbation of HIV viral load simultaneous with asymptomatic reactivation of chronic Chagas' disease
Chronic Trypanosoma cruzi infection can reactivate in patients with immunosuppression related to human immunodeficiency virus (HIV) infection, resulting in severe meningoencephalitis or myocarditis and high parasitemia. The effects of T. cruzi on HIV infection are unknown. We describe an HIV-infecte...
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| Veröffentlicht in: | The American journal of tropical medicine and hygiene 2002-11, Vol.67 (5), p.521-523 |
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| container_title | The American journal of tropical medicine and hygiene |
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| creator | Sartori, AM Caiaffa-Filho, HH Bezerra, RC do Guilherme, S C Lopes, MH Shikanai-Yasuda, MA |
| description | Chronic Trypanosoma cruzi infection can reactivate in patients with immunosuppression related to human immunodeficiency virus (HIV) infection, resulting in severe meningoencephalitis or myocarditis and high parasitemia. The effects of T. cruzi on HIV infection are unknown. We describe an HIV-infected patient with chronic Chagas' disease who experienced an asymptomatic T. cruzi reactivation characterized by the finding of the parasite in direct microscopic examination of blood. The patient's HIV viral load had increased simultaneously with the exacerbation of T. cruzi parasitemia and decreased to previous levels after successful antiparasitic treatment. This otherwise unexplained finding suggests that T. cruzi infection might up-regulate HIV replication, which may affect HIV disease progression. Asymptomatic reactivation of Chagas' disease has not been reported before. This could mean that the severe clinical manifestations related to the reactivation of trypanosomiasis are just the tip of the iceberg. |
| doi_str_mv | 10.4269/ajtmh.2002.67.521 |
| format | Article |
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The effects of T. cruzi on HIV infection are unknown. We describe an HIV-infected patient with chronic Chagas' disease who experienced an asymptomatic T. cruzi reactivation characterized by the finding of the parasite in direct microscopic examination of blood. The patient's HIV viral load had increased simultaneously with the exacerbation of T. cruzi parasitemia and decreased to previous levels after successful antiparasitic treatment. This otherwise unexplained finding suggests that T. cruzi infection might up-regulate HIV replication, which may affect HIV disease progression. Asymptomatic reactivation of Chagas' disease has not been reported before. This could mean that the severe clinical manifestations related to the reactivation of trypanosomiasis are just the tip of the iceberg.</description><identifier>ISSN: 0002-9637</identifier><identifier>EISSN: 1476-1645</identifier><identifier>DOI: 10.4269/ajtmh.2002.67.521</identifier><identifier>PMID: 12479555</identifier><identifier>CODEN: AJTHAB</identifier><language>eng</language><publisher>Lawrence, KS: ASTMH</publisher><subject>Adult ; Animals ; Biological and medical sciences ; Chagas Disease - complications ; Chagas Disease - drug therapy ; Chagas Disease - parasitology ; Chronic Disease ; Disease Progression ; HIV - isolation & purification ; HIV - physiology ; HIV Infections - complications ; HIV Infections - drug therapy ; HIV Infections - immunology ; HIV Infections - virology ; Human protozoal diseases ; Human viral diseases ; Humans ; Infectious diseases ; Male ; Medical sciences ; Parasitic diseases ; Protozoal diseases ; Recurrence ; Tropical medicine ; Trypanosoma cruzi - isolation & purification ; Trypanosomiasis ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Viral Load ; Virus Replication</subject><ispartof>The American journal of tropical medicine and hygiene, 2002-11, Vol.67 (5), p.521-523</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-f0a0f6a3e7a615b2eb81246612b1b29e34e34d13c2f8a061f5fcd9b03bdad8003</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14385363$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12479555$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sartori, AM</creatorcontrib><creatorcontrib>Caiaffa-Filho, HH</creatorcontrib><creatorcontrib>Bezerra, RC</creatorcontrib><creatorcontrib>do Guilherme, S C</creatorcontrib><creatorcontrib>Lopes, MH</creatorcontrib><creatorcontrib>Shikanai-Yasuda, MA</creatorcontrib><title>Exacerbation of HIV viral load simultaneous with asymptomatic reactivation of chronic Chagas' disease</title><title>The American journal of tropical medicine and hygiene</title><addtitle>Am J Trop Med Hyg</addtitle><description>Chronic Trypanosoma cruzi infection can reactivate in patients with immunosuppression related to human immunodeficiency virus (HIV) infection, resulting in severe meningoencephalitis or myocarditis and high parasitemia. The effects of T. cruzi on HIV infection are unknown. We describe an HIV-infected patient with chronic Chagas' disease who experienced an asymptomatic T. cruzi reactivation characterized by the finding of the parasite in direct microscopic examination of blood. The patient's HIV viral load had increased simultaneously with the exacerbation of T. cruzi parasitemia and decreased to previous levels after successful antiparasitic treatment. This otherwise unexplained finding suggests that T. cruzi infection might up-regulate HIV replication, which may affect HIV disease progression. Asymptomatic reactivation of Chagas' disease has not been reported before. This could mean that the severe clinical manifestations related to the reactivation of trypanosomiasis are just the tip of the iceberg.</description><subject>Adult</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chagas Disease - complications</subject><subject>Chagas Disease - drug therapy</subject><subject>Chagas Disease - parasitology</subject><subject>Chronic Disease</subject><subject>Disease Progression</subject><subject>HIV - isolation & purification</subject><subject>HIV - physiology</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - immunology</subject><subject>HIV Infections - virology</subject><subject>Human protozoal diseases</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Parasitic diseases</subject><subject>Protozoal diseases</subject><subject>Recurrence</subject><subject>Tropical medicine</subject><subject>Trypanosoma cruzi - isolation & purification</subject><subject>Trypanosomiasis</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><subject>Viral Load</subject><subject>Virus Replication</subject><issn>0002-9637</issn><issn>1476-1645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv3CAQhVHVqtmk_QG5RFyanrxlwGD7WK2SJlKkXtpe0RhDTITXW_DGyb8Pm11lj5GQkJjvvZnhEXIObFly1fzAh2nol5wxvlTVUnL4QBZQVqoAVcqPZMFypWiUqE7IaUoPjEHNAT6TE-Bl1UgpF8RePaGxscXJj2s6Onpz-48--oiBhhE7mvywDROu7bhNdPZTTzE9D5tpHLLC0GjRTP7xTW36OK7z-6rHe0zfaeeTxWS_kE8OQ7JfD_cZ-Xt99Wd1U9z9_nW7-nlXmFLAVDiGzCkUtkIFsuW2rfOkSgFvoeWNFWU-HQjDXY1MgZPOdE3LRNthVzMmzsjl3ncTx_9bmyY9-GRsCPsFdMUrxaGR74JQ17wWqswg7EETx5SidXoT_YDxWQPTuxD0awh6F4JWlc4hZM3FwXzbDrY7Kg6_noFvBwCTweAiro1PR64UtRRKHLne3_ezj1anAUPItqDned61e234AkBfnsA</recordid><startdate>20021101</startdate><enddate>20021101</enddate><creator>Sartori, AM</creator><creator>Caiaffa-Filho, HH</creator><creator>Bezerra, RC</creator><creator>do Guilherme, S C</creator><creator>Lopes, MH</creator><creator>Shikanai-Yasuda, MA</creator><general>ASTMH</general><general>Allen Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>20021101</creationdate><title>Exacerbation of HIV viral load simultaneous with asymptomatic reactivation of chronic Chagas' disease</title><author>Sartori, AM ; Caiaffa-Filho, HH ; Bezerra, RC ; do Guilherme, S C ; Lopes, MH ; Shikanai-Yasuda, MA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-f0a0f6a3e7a615b2eb81246612b1b29e34e34d13c2f8a061f5fcd9b03bdad8003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chagas Disease - complications</topic><topic>Chagas Disease - drug therapy</topic><topic>Chagas Disease - parasitology</topic><topic>Chronic Disease</topic><topic>Disease Progression</topic><topic>HIV - isolation & purification</topic><topic>HIV - physiology</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - immunology</topic><topic>HIV Infections - virology</topic><topic>Human protozoal diseases</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Parasitic diseases</topic><topic>Protozoal diseases</topic><topic>Recurrence</topic><topic>Tropical medicine</topic><topic>Trypanosoma cruzi - isolation & purification</topic><topic>Trypanosomiasis</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><topic>Viral Load</topic><topic>Virus Replication</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sartori, AM</creatorcontrib><creatorcontrib>Caiaffa-Filho, HH</creatorcontrib><creatorcontrib>Bezerra, RC</creatorcontrib><creatorcontrib>do Guilherme, S C</creatorcontrib><creatorcontrib>Lopes, MH</creatorcontrib><creatorcontrib>Shikanai-Yasuda, MA</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of tropical medicine and hygiene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sartori, AM</au><au>Caiaffa-Filho, HH</au><au>Bezerra, RC</au><au>do Guilherme, S C</au><au>Lopes, MH</au><au>Shikanai-Yasuda, MA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exacerbation of HIV viral load simultaneous with asymptomatic reactivation of chronic Chagas' disease</atitle><jtitle>The American journal of tropical medicine and hygiene</jtitle><addtitle>Am J Trop Med Hyg</addtitle><date>2002-11-01</date><risdate>2002</risdate><volume>67</volume><issue>5</issue><spage>521</spage><epage>523</epage><pages>521-523</pages><issn>0002-9637</issn><eissn>1476-1645</eissn><coden>AJTHAB</coden><abstract>Chronic Trypanosoma cruzi infection can reactivate in patients with immunosuppression related to human immunodeficiency virus (HIV) infection, resulting in severe meningoencephalitis or myocarditis and high parasitemia. The effects of T. cruzi on HIV infection are unknown. We describe an HIV-infected patient with chronic Chagas' disease who experienced an asymptomatic T. cruzi reactivation characterized by the finding of the parasite in direct microscopic examination of blood. The patient's HIV viral load had increased simultaneously with the exacerbation of T. cruzi parasitemia and decreased to previous levels after successful antiparasitic treatment. This otherwise unexplained finding suggests that T. cruzi infection might up-regulate HIV replication, which may affect HIV disease progression. Asymptomatic reactivation of Chagas' disease has not been reported before. This could mean that the severe clinical manifestations related to the reactivation of trypanosomiasis are just the tip of the iceberg.</abstract><cop>Lawrence, KS</cop><pub>ASTMH</pub><pmid>12479555</pmid><doi>10.4269/ajtmh.2002.67.521</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Animals Biological and medical sciences Chagas Disease - complications Chagas Disease - drug therapy Chagas Disease - parasitology Chronic Disease Disease Progression HIV - isolation & purification HIV - physiology HIV Infections - complications HIV Infections - drug therapy HIV Infections - immunology HIV Infections - virology Human protozoal diseases Human viral diseases Humans Infectious diseases Male Medical sciences Parasitic diseases Protozoal diseases Recurrence Tropical medicine Trypanosoma cruzi - isolation & purification Trypanosomiasis Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load Virus Replication |
| title | Exacerbation of HIV viral load simultaneous with asymptomatic reactivation of chronic Chagas' disease |
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