The decomposition of thionitrites

The decomposition of thionitrites

The mechanism of thionitrite decomposition, both in vivo and in vitro, remains unclear. Thionitrite stability is highly variable; it is a complex function of thionitrite structure and environmental condition. Several recent advances clarify the role of unimolecular homlytic decomposition, metal-cata...

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Veröffentlicht in:Current Opinion in Chemical Biology 2002-12, Vol.6 (6), p.779-785
Hauptverfasser: Stamler, Jonathan S, Toone, Eric J
Format: Artikel
Sprache:eng
Schlagworte:
Aldehyde Oxidoreductases - metabolism
Animals
Copper - chemistry
Copper - pharmacology
Drug Stability
Humans
Kinetics
Nitric oxide
Nitric Oxide - chemistry
Nitrites - chemistry
Nitrites - metabolism
nitrosothiol stability
Oxidation-Reduction
Oxygen - chemistry
Oxygen - pharmacology
Sulfhydryl Compounds - chemistry
Sulfhydryl Compounds - metabolism
Sulfur - chemistry
thionitrite stability
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Zusammenfassung:The mechanism of thionitrite decomposition, both in vivo and in vitro, remains unclear. Thionitrite stability is highly variable; it is a complex function of thionitrite structure and environmental condition. Several recent advances clarify the role of unimolecular homlytic decomposition, metal-catalyzed reductive decomposition and higher-order enzymatic and non-enzymatic processes to the overall observed stability of thionitrites. The importance of various unimolecular and bimolecular processes to thionitrite decomposition is considered.
ISSN:1367-5931
1879-0402
DOI:10.1016/S1367-5931(02)00383-6