A Single Nucleotide Polymorphism in the Matrix Metalloproteinase-3 Promoter Enhances Breast Cancer Susceptibility

Purpose: Matrix metalloproteinases (MMPs) are likely to be involved in invasion and metastasis of several tumors by degrading the extracellular matrix. A single adenine insertion/deletion polymorphism (5A/6A) in the MMP-3 promoter region causes the elevation of transcriptional level and local expres...

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Veröffentlicht in:	Clinical cancer research 2002-12, Vol.8 (12), p.3820-3823
Hauptverfasser:	GHILARDI, Giorgio, BIONDI, Maria Luisa, CAPUTO, Maria, LEVITI, Simona, DEMONTI, Marco, GUAGNELLINI, Emma, SCORZA, Roberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - enzymology Adenocarcinoma - genetics Adult Aged Aged, 80 and over Biological and medical sciences Breast Neoplasms - enzymology Breast Neoplasms - genetics Case-Control Studies DNA Mutational Analysis Female Gene Frequency Genetic Predisposition to Disease Genotype Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Matrix Metalloproteinase 1 - genetics Matrix Metalloproteinase 3 - genetics Medical sciences Middle Aged Neoplasm Invasiveness Neoplasm Staging Pilot Projects Polymorphism, Single Nucleotide - genetics Promoter Regions, Genetic - genetics Tumors
Online-Zugang:	Volltext
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