Advanced presentation of lung cancer in Asian immigrants: A case-control study
To determine if Asian immigrants to the United States present with more advanced lung cancer compared to non-Asians. A 5-year retrospective case-control study (January 1, 1992, to December 31, 1996) of patients with lung cancer identified using the New England Medical Center cancer center database....
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| Veröffentlicht in: | Chest 2002-12, Vol.122 (6), p.1938-1943 |
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| container_issue | 6 |
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| container_title | Chest |
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| creator | FINLAY, Geraldine A JOSEPH, Brenda RODRIGUES, Cynthia R GRIFFITH, John WHITE, Alexander C |
| description | To determine if Asian immigrants to the United States present with more advanced lung cancer compared to non-Asians.
A 5-year retrospective case-control study (January 1, 1992, to December 31, 1996) of patients with lung cancer identified using the New England Medical Center cancer center database. A 2-year follow up was obtained in all subjects.
A tertiary level care hospital providing all levels of medical care to the local Asian population in the Boston area.
Forty-two Asian immigrants with lung cancer diagnosed over the study period were matched for age and sex with 42 non-Asian control subjects.
Asians presented more frequently with advanced stage (stage III or IV) and less frequently with early stage (stage I or II) lung cancer compared with the non-Asian control group (p < 0.05). Asians were more likely to present with hemoptysis or constitutional symptoms (p < 0.01) and had a longer duration of symptoms prior to presentation (p < 0.01) compared with non-Asians. There was no difference in the length of time elapsed between diagnosis and start of treatment (approximation of workup time) between the two groups. The utilization of tests and procedures for clinical disease staging was not significantly different between the two groups. The incidence of large cell carcinoma (p < 0.05) was higher in Asians compared with non-Asians. Asians were more likely to receive radiotherapy and less likely to receive combination therapy compared with non-Asians (p < 0.05). The treatment of stage I and II lung cancer did not differ between the two groups. The median 2-year survival was significantly reduced in Asians compared with non-Asians: Asians, 7 months (95% confidence interval [CI], 3.1 to 10.9); non-Asians, 15 months (95% CI, 12.0 to 17.5) [p < 0.001].
Asian immigrants with lung cancer appear to present with more advanced stage of disease, have more prolonged symptomatology, and have reduced survival compared with non-Asians. These data suggest that ethnicity may play a role in the presentation and outcome of lung cancer in the Asian immigrant population. |
| doi_str_mv | 10.1378/chest.122.6.1938 |
| format | Article |
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A 5-year retrospective case-control study (January 1, 1992, to December 31, 1996) of patients with lung cancer identified using the New England Medical Center cancer center database. A 2-year follow up was obtained in all subjects.
A tertiary level care hospital providing all levels of medical care to the local Asian population in the Boston area.
Forty-two Asian immigrants with lung cancer diagnosed over the study period were matched for age and sex with 42 non-Asian control subjects.
Asians presented more frequently with advanced stage (stage III or IV) and less frequently with early stage (stage I or II) lung cancer compared with the non-Asian control group (p < 0.05). Asians were more likely to present with hemoptysis or constitutional symptoms (p < 0.01) and had a longer duration of symptoms prior to presentation (p < 0.01) compared with non-Asians. There was no difference in the length of time elapsed between diagnosis and start of treatment (approximation of workup time) between the two groups. The utilization of tests and procedures for clinical disease staging was not significantly different between the two groups. The incidence of large cell carcinoma (p < 0.05) was higher in Asians compared with non-Asians. Asians were more likely to receive radiotherapy and less likely to receive combination therapy compared with non-Asians (p < 0.05). The treatment of stage I and II lung cancer did not differ between the two groups. The median 2-year survival was significantly reduced in Asians compared with non-Asians: Asians, 7 months (95% confidence interval [CI], 3.1 to 10.9); non-Asians, 15 months (95% CI, 12.0 to 17.5) [p < 0.001].
Asian immigrants with lung cancer appear to present with more advanced stage of disease, have more prolonged symptomatology, and have reduced survival compared with non-Asians. These data suggest that ethnicity may play a role in the presentation and outcome of lung cancer in the Asian immigrant population.]]></description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.122.6.1938</identifier><identifier>PMID: 12475830</identifier><identifier>CODEN: CHETBF</identifier><language>eng</language><publisher>Northbrook, IL: American College of Chest Physicians</publisher><subject>Aged ; Asia - ethnology ; Asians ; Attitude ; Biological and medical sciences ; Boston ; Case-Control Studies ; Demographic aspects ; Disease susceptibility ; Emigration and Immigration ; Health aspects ; Humans ; Immigrants ; Lung cancer ; Lung Neoplasms - mortality ; Lung Neoplasms - pathology ; Male ; Medical sciences ; Pneumology ; Tumors of the respiratory system and mediastinum</subject><ispartof>Chest, 2002-12, Vol.122 (6), p.1938-1943</ispartof><rights>2003 INIST-CNRS</rights><rights>COPYRIGHT 2002 Elsevier B.V.</rights><rights>Copyright American College of Chest Physicians Dec 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14409050$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12475830$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FINLAY, Geraldine A</creatorcontrib><creatorcontrib>JOSEPH, Brenda</creatorcontrib><creatorcontrib>RODRIGUES, Cynthia R</creatorcontrib><creatorcontrib>GRIFFITH, John</creatorcontrib><creatorcontrib>WHITE, Alexander C</creatorcontrib><title>Advanced presentation of lung cancer in Asian immigrants: A case-control study</title><title>Chest</title><addtitle>Chest</addtitle><description><![CDATA[To determine if Asian immigrants to the United States present with more advanced lung cancer compared to non-Asians.
A 5-year retrospective case-control study (January 1, 1992, to December 31, 1996) of patients with lung cancer identified using the New England Medical Center cancer center database. A 2-year follow up was obtained in all subjects.
A tertiary level care hospital providing all levels of medical care to the local Asian population in the Boston area.
Forty-two Asian immigrants with lung cancer diagnosed over the study period were matched for age and sex with 42 non-Asian control subjects.
Asians presented more frequently with advanced stage (stage III or IV) and less frequently with early stage (stage I or II) lung cancer compared with the non-Asian control group (p < 0.05). Asians were more likely to present with hemoptysis or constitutional symptoms (p < 0.01) and had a longer duration of symptoms prior to presentation (p < 0.01) compared with non-Asians. There was no difference in the length of time elapsed between diagnosis and start of treatment (approximation of workup time) between the two groups. The utilization of tests and procedures for clinical disease staging was not significantly different between the two groups. The incidence of large cell carcinoma (p < 0.05) was higher in Asians compared with non-Asians. Asians were more likely to receive radiotherapy and less likely to receive combination therapy compared with non-Asians (p < 0.05). The treatment of stage I and II lung cancer did not differ between the two groups. The median 2-year survival was significantly reduced in Asians compared with non-Asians: Asians, 7 months (95% confidence interval [CI], 3.1 to 10.9); non-Asians, 15 months (95% CI, 12.0 to 17.5) [p < 0.001].
Asian immigrants with lung cancer appear to present with more advanced stage of disease, have more prolonged symptomatology, and have reduced survival compared with non-Asians. These data suggest that ethnicity may play a role in the presentation and outcome of lung cancer in the Asian immigrant population.]]></description><subject>Aged</subject><subject>Asia - ethnology</subject><subject>Asians</subject><subject>Attitude</subject><subject>Biological and medical sciences</subject><subject>Boston</subject><subject>Case-Control Studies</subject><subject>Demographic aspects</subject><subject>Disease susceptibility</subject><subject>Emigration and Immigration</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Immigrants</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - mortality</subject><subject>Lung Neoplasms - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pneumology</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpt0c9r2zAUB3BRVpY0272nIQbtqc4kPUc_djOh7QahvXRnI8uyp2JLqWQP8t9XIxmDUnR4SO-D9PgKoUtK1hSE_GZ-2zStKWNrvqYK5Bla5kIL2JTwAS0JoawArtgCXaT0TPKeKv4RLSgrxUYCWaKHqv2jvbEt3kebrJ_05ILHocPD7Hts_vYidh5XyWmP3Ti6Pmo_pe-4yt1kCxP8FMOA0zS3h0_ovNNDsp9PdYV-3d0-bX8Uu8f7n9tqV_QAaiqkEpDf5MRQCp0VugFpmGi0YbRrqaCsI0RapgCkNoaVplFNKxknWQjGYYWuj_fuY3iZcwj16JKxw6C9DXOqBROcMAkZfn0Dn8McfZ6tZoSUGw6SZXRzRL0ebO18F6aoTW-9jXoI3nYuH1eKA-E5wsyLd3herR2dec9_Oc0wN6Nt6310o46H-t8vZHB1AjoZPXQ5YOPSf1eWRJENgVeHU5Uu</recordid><startdate>20021201</startdate><enddate>20021201</enddate><creator>FINLAY, Geraldine A</creator><creator>JOSEPH, Brenda</creator><creator>RODRIGUES, Cynthia R</creator><creator>GRIFFITH, John</creator><creator>WHITE, Alexander C</creator><general>American College of Chest Physicians</general><general>Elsevier B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20021201</creationdate><title>Advanced presentation of lung cancer in Asian immigrants: A case-control study</title><author>FINLAY, Geraldine A ; JOSEPH, Brenda ; RODRIGUES, Cynthia R ; GRIFFITH, John ; WHITE, Alexander C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g339t-8973ced60c113fe7ab38c27bac21fd1712f008e29338acc24cb9bd8260ac27263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Aged</topic><topic>Asia - ethnology</topic><topic>Asians</topic><topic>Attitude</topic><topic>Biological and medical sciences</topic><topic>Boston</topic><topic>Case-Control Studies</topic><topic>Demographic aspects</topic><topic>Disease susceptibility</topic><topic>Emigration and Immigration</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Immigrants</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - mortality</topic><topic>Lung Neoplasms - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pneumology</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FINLAY, Geraldine A</creatorcontrib><creatorcontrib>JOSEPH, Brenda</creatorcontrib><creatorcontrib>RODRIGUES, Cynthia R</creatorcontrib><creatorcontrib>GRIFFITH, John</creatorcontrib><creatorcontrib>WHITE, Alexander C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FINLAY, Geraldine A</au><au>JOSEPH, Brenda</au><au>RODRIGUES, Cynthia R</au><au>GRIFFITH, John</au><au>WHITE, Alexander C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Advanced presentation of lung cancer in Asian immigrants: A case-control study</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>2002-12-01</date><risdate>2002</risdate><volume>122</volume><issue>6</issue><spage>1938</spage><epage>1943</epage><pages>1938-1943</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><coden>CHETBF</coden><abstract><![CDATA[To determine if Asian immigrants to the United States present with more advanced lung cancer compared to non-Asians.
A 5-year retrospective case-control study (January 1, 1992, to December 31, 1996) of patients with lung cancer identified using the New England Medical Center cancer center database. A 2-year follow up was obtained in all subjects.
A tertiary level care hospital providing all levels of medical care to the local Asian population in the Boston area.
Forty-two Asian immigrants with lung cancer diagnosed over the study period were matched for age and sex with 42 non-Asian control subjects.
Asians presented more frequently with advanced stage (stage III or IV) and less frequently with early stage (stage I or II) lung cancer compared with the non-Asian control group (p < 0.05). Asians were more likely to present with hemoptysis or constitutional symptoms (p < 0.01) and had a longer duration of symptoms prior to presentation (p < 0.01) compared with non-Asians. There was no difference in the length of time elapsed between diagnosis and start of treatment (approximation of workup time) between the two groups. The utilization of tests and procedures for clinical disease staging was not significantly different between the two groups. The incidence of large cell carcinoma (p < 0.05) was higher in Asians compared with non-Asians. Asians were more likely to receive radiotherapy and less likely to receive combination therapy compared with non-Asians (p < 0.05). The treatment of stage I and II lung cancer did not differ between the two groups. The median 2-year survival was significantly reduced in Asians compared with non-Asians: Asians, 7 months (95% confidence interval [CI], 3.1 to 10.9); non-Asians, 15 months (95% CI, 12.0 to 17.5) [p < 0.001].
Asian immigrants with lung cancer appear to present with more advanced stage of disease, have more prolonged symptomatology, and have reduced survival compared with non-Asians. These data suggest that ethnicity may play a role in the presentation and outcome of lung cancer in the Asian immigrant population.]]></abstract><cop>Northbrook, IL</cop><pub>American College of Chest Physicians</pub><pmid>12475830</pmid><doi>10.1378/chest.122.6.1938</doi><tpages>6</tpages></addata></record> |
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| ispartof | Chest, 2002-12, Vol.122 (6), p.1938-1943 |
| issn | 0012-3692 1931-3543 |
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| subjects | Aged Asia - ethnology Asians Attitude Biological and medical sciences Boston Case-Control Studies Demographic aspects Disease susceptibility Emigration and Immigration Health aspects Humans Immigrants Lung cancer Lung Neoplasms - mortality Lung Neoplasms - pathology Male Medical sciences Pneumology Tumors of the respiratory system and mediastinum |
| title | Advanced presentation of lung cancer in Asian immigrants: A case-control study |
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