Induction of Apoptosis in Mesothelioma Cells by Antisurvivin Oligonucleotides

Malignant pleural mesothelioma is a rare and aggressive tumor characterized by rapid progression, late metastases, and poor prognosis. In this study, we investigated the expression of survivin, a member of the inhibitors of apoptosis protein gene family, in mesothelioma and an antisense oligonucleot...

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Veröffentlicht in:	Molecular cancer therapeutics 2002-07, Vol.1 (9), p.687-694
Hauptverfasser:	Xia, Chunyao, Xu, Zhidong, Yuan, Xiaocheng, Uematsu, Kazutsugu, You, Liang, Li, Kai, Li, Li, McCormick, Frank, Jablons, David M
Format:	Artikel
Sprache:	eng
Schlagworte:	Annexin A5 - pharmacology Apoptosis Blotting, Western Caspase 3 Caspases - metabolism Cell Division Cell Survival DNA, Complementary - metabolism Dose-Response Relationship, Drug Down-Regulation Flow Cytometry Genetic Therapy Humans Inhibitor of Apoptosis Proteins Mesothelioma - pathology Mesothelioma - therapy Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Microtubule-Associated Proteins - pharmacology Neoplasm Proteins Oligonucleotide Array Sequence Analysis Oligonucleotides - pharmacology Oligonucleotides, Antisense - pharmacology Proto-Oncogene Proteins c-bcl-2 - metabolism Reverse Transcriptase Polymerase Chain Reaction Time Factors Transfection Tumor Cells, Cultured
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