Zebrafish as a Model Organism for the Identification and Characterization of Drugs and Genes Affecting p53 Signaling

p53 and its main negative regulator, Mdm2, are key players in mammalian cancer development. Activation of the transcription factor p53 through DNA damage or other stresses can result in cell cycle arrest, apoptosis, or both [1, 2]. Because of the absence of characterized p53 signaling in zebrafish (...

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