Prodomains and Protein Folding Catalysis

Bryan describes what general inferences about protein folding can be made from prodomain catalyzed folding. General questions include whether native protein conformation is always thermodynamically determined, what causes high kinetic barriers between unfolded and native states, and what do prodomai...

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Veröffentlicht in:	Chemical reviews 2002-12, Vol.102 (12), p.4805-4816
1. Verfasser:	Bryan, Philip N
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - chemistry Biochemistry Catalysis Endopeptidases - chemistry Enzyme Precursors - chemistry Enzyme Stability Kinetics Protein Folding Protein Precursors - chemistry Protein Structure, Tertiary Proteins Thermodynamics
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Bryan describes what general inferences about protein folding can be made from prodomain catalyzed folding. General questions include whether native protein conformation is always thermodynamically determined, what causes high kinetic barriers between unfolded and native states, and what do prodomains do to reduce these kinetic barriers.
ISSN:	0009-2665 1520-6890
DOI:	10.1021/cr010190b