Hemangiomas of Infancy: Clinical Characteristics, Morphologic Subtypes, and Their Relationship to Race, Ethnicity, and Sex
BACKGROUND Hemangiomas of infancy vary widely in appearance, size, and depth of cutaneous involvement. There is currently no standard classification system for these lesions. While they occur in any race, an increased incidence occurs in girls, light-skinned whites, and premature infants, especially...
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| Veröffentlicht in: | Archives of dermatology (1960) 2002-12, Vol.138 (12), p.1567-1576 |
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| creator | Chiller, Katarina G Passaro, Douglas Frieden, Ilona J |
| description | BACKGROUND Hemangiomas of infancy vary widely in appearance, size, and depth of cutaneous involvement. There is currently no standard classification system for these lesions. While they occur in any race, an increased incidence occurs in girls, light-skinned whites, and premature infants, especially those weighing less than 1500 g. Other epidemiologic and demographic factors have not been well characterized. OBJECTIVE To determine any correlations between hemangioma subtype and anatomic location with demographic factors, complications, and other associated anomalies. DESIGN Retrospective chart review of 327 patients with hemangioma of infancy seen between 1997 and 2000 in an ambulatory referral center. MAIN OUTCOMES MEASURES Demographic and gestational information, lesion size, associated anomalies, complications, treatments, and outcomes were analyzed together with classification of hemangiomas into 4 groups: localized, segmental, indeterminate, and multifocal. Subtypes were correlated with race and ethnicity, the incidence of complications, and overall outcome. RESULTS Of 472 hemangiomas (327 patients), 339 (72%) were localized, 84 (18%) were segmental, 37 (8%) were indeterminate, and 12 (3%) were multifocal (8 or more noncontiguous lesions). Segmental lesions were larger and were more frequently associated with developmental abnormalities. They also required more intensive and prolonged therapy and were associated with more complications and a poorer overall outcome (P |
| doi_str_mv | 10.1001/archderm.138.12.1567 |
| format | Article |
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There is currently no standard classification system for these lesions. While they occur in any race, an increased incidence occurs in girls, light-skinned whites, and premature infants, especially those weighing less than 1500 g. Other epidemiologic and demographic factors have not been well characterized. OBJECTIVE To determine any correlations between hemangioma subtype and anatomic location with demographic factors, complications, and other associated anomalies. DESIGN Retrospective chart review of 327 patients with hemangioma of infancy seen between 1997 and 2000 in an ambulatory referral center. MAIN OUTCOMES MEASURES Demographic and gestational information, lesion size, associated anomalies, complications, treatments, and outcomes were analyzed together with classification of hemangiomas into 4 groups: localized, segmental, indeterminate, and multifocal. Subtypes were correlated with race and ethnicity, the incidence of complications, and overall outcome. RESULTS Of 472 hemangiomas (327 patients), 339 (72%) were localized, 84 (18%) were segmental, 37 (8%) were indeterminate, and 12 (3%) were multifocal (8 or more noncontiguous lesions). Segmental lesions were larger and were more frequently associated with developmental abnormalities. They also required more intensive and prolonged therapy and were associated with more complications and a poorer overall outcome (P<.001). Lesions on Hispanic patients were more likely to involve mucous membranes, to be segmental (P<.004), to be associated with abnormalities (P = .05), especially PHACE syndrome (P = .05), and to have more complications (P = .01). Increased incidence of segmental hemangiomas was the only factor in Hispanic infants associated with complications, more extensive treatment, or associated anomalies. CONCLUSIONS Hemangiomas of infancy can usually be classified as localized, segmental, indeterminate, and multifocal, based on clinical features. Segmental lesions have a higher frequency of complications and associated abnormalities, and this type of hemangioma seems to present with increased frequency in Hispanic infants.Arch Dermatol. 2002;138:1567-1576--></description><identifier>ISSN: 0003-987X</identifier><identifier>ISSN: 2168-6068</identifier><identifier>EISSN: 1538-3652</identifier><identifier>EISSN: 2168-6084</identifier><identifier>DOI: 10.1001/archderm.138.12.1567</identifier><identifier>PMID: 12472344</identifier><identifier>CODEN: ARDEAC</identifier><language>eng</language><publisher>Chicago, IL: American Medical Association</publisher><subject>Biological and medical sciences ; Biopsy, Needle ; Combined Modality Therapy - methods ; Dermatology ; Facial Neoplasms - diagnosis ; Facial Neoplasms - epidemiology ; Facial Neoplasms - therapy ; Female ; Hemangioma - diagnosis ; Hemangioma - epidemiology ; Hemangioma - therapy ; Hispanic Americans - statistics & numerical data ; Humans ; Incidence ; Infant ; Male ; Medical sciences ; Multivariate Analysis ; Probability ; Prognosis ; Retrospective Studies ; Risk Assessment ; Severity of Illness Index ; Sex Distribution ; Skin Neoplasms - diagnosis ; Skin Neoplasms - epidemiology ; Skin Neoplasms - therapy ; United States - epidemiology ; Vascular disorders of the skin</subject><ispartof>Archives of dermatology (1960), 2002-12, Vol.138 (12), p.1567-1576</ispartof><rights>2003 INIST-CNRS</rights><rights>Copyright American Medical Association Dec 2002</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jamanetwork.com/journals/jamadermatology/articlepdf/10.1001/archderm.138.12.1567$$EPDF$$P50$$Gama$$H</linktopdf><linktohtml>$$Uhttps://jamanetwork.com/journals/jamadermatology/fullarticle/10.1001/archderm.138.12.1567$$EHTML$$P50$$Gama$$H</linktohtml><link.rule.ids>64,314,776,780,3327,27901,27902,76232,76235</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14424859$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12472344$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chiller, Katarina G</creatorcontrib><creatorcontrib>Passaro, Douglas</creatorcontrib><creatorcontrib>Frieden, Ilona J</creatorcontrib><title>Hemangiomas of Infancy: Clinical Characteristics, Morphologic Subtypes, and Their Relationship to Race, Ethnicity, and Sex</title><title>Archives of dermatology (1960)</title><addtitle>Arch Dermatol</addtitle><description>BACKGROUND Hemangiomas of infancy vary widely in appearance, size, and depth of cutaneous involvement. There is currently no standard classification system for these lesions. While they occur in any race, an increased incidence occurs in girls, light-skinned whites, and premature infants, especially those weighing less than 1500 g. Other epidemiologic and demographic factors have not been well characterized. OBJECTIVE To determine any correlations between hemangioma subtype and anatomic location with demographic factors, complications, and other associated anomalies. DESIGN Retrospective chart review of 327 patients with hemangioma of infancy seen between 1997 and 2000 in an ambulatory referral center. MAIN OUTCOMES MEASURES Demographic and gestational information, lesion size, associated anomalies, complications, treatments, and outcomes were analyzed together with classification of hemangiomas into 4 groups: localized, segmental, indeterminate, and multifocal. Subtypes were correlated with race and ethnicity, the incidence of complications, and overall outcome. RESULTS Of 472 hemangiomas (327 patients), 339 (72%) were localized, 84 (18%) were segmental, 37 (8%) were indeterminate, and 12 (3%) were multifocal (8 or more noncontiguous lesions). Segmental lesions were larger and were more frequently associated with developmental abnormalities. They also required more intensive and prolonged therapy and were associated with more complications and a poorer overall outcome (P<.001). Lesions on Hispanic patients were more likely to involve mucous membranes, to be segmental (P<.004), to be associated with abnormalities (P = .05), especially PHACE syndrome (P = .05), and to have more complications (P = .01). Increased incidence of segmental hemangiomas was the only factor in Hispanic infants associated with complications, more extensive treatment, or associated anomalies. CONCLUSIONS Hemangiomas of infancy can usually be classified as localized, segmental, indeterminate, and multifocal, based on clinical features. Segmental lesions have a higher frequency of complications and associated abnormalities, and this type of hemangioma seems to present with increased frequency in Hispanic infants.Arch Dermatol. 2002;138:1567-1576--></description><subject>Biological and medical sciences</subject><subject>Biopsy, Needle</subject><subject>Combined Modality Therapy - methods</subject><subject>Dermatology</subject><subject>Facial Neoplasms - diagnosis</subject><subject>Facial Neoplasms - epidemiology</subject><subject>Facial Neoplasms - therapy</subject><subject>Female</subject><subject>Hemangioma - diagnosis</subject><subject>Hemangioma - epidemiology</subject><subject>Hemangioma - therapy</subject><subject>Hispanic Americans - statistics & numerical data</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infant</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Multivariate Analysis</subject><subject>Probability</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Severity of Illness Index</subject><subject>Sex Distribution</subject><subject>Skin Neoplasms - diagnosis</subject><subject>Skin Neoplasms - epidemiology</subject><subject>Skin Neoplasms - therapy</subject><subject>United States - epidemiology</subject><subject>Vascular disorders of the skin</subject><issn>0003-987X</issn><issn>2168-6068</issn><issn>1538-3652</issn><issn>2168-6084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkV1rFDEUhoModlv9AYJIEOpVZ83HTJL1TpZqCxWhreBdOJM500mZmUyTGXD99absasGrwMnzvhzOQ8hbztacMf4RousajMOaS7PmYs0rpZ-RFa-kKaSqxHOyYozJYmP0zyNynNJ9TgljxEtyxEWphSzLFfl9gQOMdz4MkGho6eXYwuh2n-i296N30NNtBxHcjNGn2bt0Rr-FOHWhD3fe0ZulnncT5imMDb3t0Ed6jT3MPoyp8xOdA70Gh2f0fO5yn593e_QGf70iL1roE74-vCfkx5fz2-1FcfX96-X281UBUui5QActoqo4yz2oWK2VKcFwWTPjlKpQtkI0jWGIrmGsbpRjauMaXTIJWnJ5Qj7se6cYHhZMsx18ctj3MGJYktVCV9pIkcH3_4H3YYlj3s0KKbngRqsMlXvIxZBSxNZO0Q8Qd5Yz-yjG_hVjsxjLhX0Uk2PvDt1LPWDzFDqYyMDpAYCUz97GrMGnJ64sRWmqTebe7DkY4N9vqTecKfkHZHehfQ</recordid><startdate>20021201</startdate><enddate>20021201</enddate><creator>Chiller, Katarina G</creator><creator>Passaro, Douglas</creator><creator>Frieden, Ilona J</creator><general>American Medical Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20021201</creationdate><title>Hemangiomas of Infancy: Clinical Characteristics, Morphologic Subtypes, and Their Relationship to Race, Ethnicity, and Sex</title><author>Chiller, Katarina G ; Passaro, Douglas ; Frieden, Ilona J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a327t-ecafee6510acee60b7684a813b08c665e3f22dd80eecd00bd6c069cd7403a7313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Biological and medical sciences</topic><topic>Biopsy, Needle</topic><topic>Combined Modality Therapy - methods</topic><topic>Dermatology</topic><topic>Facial Neoplasms - diagnosis</topic><topic>Facial Neoplasms - epidemiology</topic><topic>Facial Neoplasms - therapy</topic><topic>Female</topic><topic>Hemangioma - diagnosis</topic><topic>Hemangioma - epidemiology</topic><topic>Hemangioma - therapy</topic><topic>Hispanic Americans - statistics & numerical data</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infant</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Multivariate Analysis</topic><topic>Probability</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Severity of Illness Index</topic><topic>Sex Distribution</topic><topic>Skin Neoplasms - diagnosis</topic><topic>Skin Neoplasms - epidemiology</topic><topic>Skin Neoplasms - therapy</topic><topic>United States - epidemiology</topic><topic>Vascular disorders of the skin</topic><toplevel>online_resources</toplevel><creatorcontrib>Chiller, Katarina G</creatorcontrib><creatorcontrib>Passaro, Douglas</creatorcontrib><creatorcontrib>Frieden, Ilona J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of dermatology (1960)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chiller, Katarina G</au><au>Passaro, Douglas</au><au>Frieden, Ilona J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hemangiomas of Infancy: Clinical Characteristics, Morphologic Subtypes, and Their Relationship to Race, Ethnicity, and Sex</atitle><jtitle>Archives of dermatology (1960)</jtitle><addtitle>Arch Dermatol</addtitle><date>2002-12-01</date><risdate>2002</risdate><volume>138</volume><issue>12</issue><spage>1567</spage><epage>1576</epage><pages>1567-1576</pages><issn>0003-987X</issn><issn>2168-6068</issn><eissn>1538-3652</eissn><eissn>2168-6084</eissn><coden>ARDEAC</coden><abstract>BACKGROUND Hemangiomas of infancy vary widely in appearance, size, and depth of cutaneous involvement. There is currently no standard classification system for these lesions. While they occur in any race, an increased incidence occurs in girls, light-skinned whites, and premature infants, especially those weighing less than 1500 g. Other epidemiologic and demographic factors have not been well characterized. OBJECTIVE To determine any correlations between hemangioma subtype and anatomic location with demographic factors, complications, and other associated anomalies. DESIGN Retrospective chart review of 327 patients with hemangioma of infancy seen between 1997 and 2000 in an ambulatory referral center. MAIN OUTCOMES MEASURES Demographic and gestational information, lesion size, associated anomalies, complications, treatments, and outcomes were analyzed together with classification of hemangiomas into 4 groups: localized, segmental, indeterminate, and multifocal. Subtypes were correlated with race and ethnicity, the incidence of complications, and overall outcome. RESULTS Of 472 hemangiomas (327 patients), 339 (72%) were localized, 84 (18%) were segmental, 37 (8%) were indeterminate, and 12 (3%) were multifocal (8 or more noncontiguous lesions). Segmental lesions were larger and were more frequently associated with developmental abnormalities. They also required more intensive and prolonged therapy and were associated with more complications and a poorer overall outcome (P<.001). Lesions on Hispanic patients were more likely to involve mucous membranes, to be segmental (P<.004), to be associated with abnormalities (P = .05), especially PHACE syndrome (P = .05), and to have more complications (P = .01). Increased incidence of segmental hemangiomas was the only factor in Hispanic infants associated with complications, more extensive treatment, or associated anomalies. CONCLUSIONS Hemangiomas of infancy can usually be classified as localized, segmental, indeterminate, and multifocal, based on clinical features. Segmental lesions have a higher frequency of complications and associated abnormalities, and this type of hemangioma seems to present with increased frequency in Hispanic infants.Arch Dermatol. 2002;138:1567-1576--></abstract><cop>Chicago, IL</cop><pub>American Medical Association</pub><pmid>12472344</pmid><doi>10.1001/archderm.138.12.1567</doi><tpages>10</tpages></addata></record> |
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| ispartof | Archives of dermatology (1960), 2002-12, Vol.138 (12), p.1567-1576 |
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| subjects | Biological and medical sciences Biopsy, Needle Combined Modality Therapy - methods Dermatology Facial Neoplasms - diagnosis Facial Neoplasms - epidemiology Facial Neoplasms - therapy Female Hemangioma - diagnosis Hemangioma - epidemiology Hemangioma - therapy Hispanic Americans - statistics & numerical data Humans Incidence Infant Male Medical sciences Multivariate Analysis Probability Prognosis Retrospective Studies Risk Assessment Severity of Illness Index Sex Distribution Skin Neoplasms - diagnosis Skin Neoplasms - epidemiology Skin Neoplasms - therapy United States - epidemiology Vascular disorders of the skin |
| title | Hemangiomas of Infancy: Clinical Characteristics, Morphologic Subtypes, and Their Relationship to Race, Ethnicity, and Sex |
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