Gross Variability in the Detection of Prolactin in Sera Containing Big Big Prolactin (Macroprolactin) by Commercial Immunoassays

A high molecular mass form of prolactin (PRL), macroprolactin, accumulates in the sera of some subjects. Although macroprolactin exhibits limited bioactivity in vivo, it retains immunoreactivity. We examined the frequency of macroprolactinemia in clinical practice and the ability of immunoassay syst...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2002-12, Vol.87 (12), p.5410-5415
Hauptverfasser:	Smith, Thomas P., Suliman, Abdulwahab M., Fahie-Wilson, Michael N., McKenna, T. Joseph
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Chromatography, Gel Endocrinology Female Fundamental and applied biological sciences. Psychology Hormones and neuropeptides. Regulation Humans Hyperprolactinemia - blood Hypothalamus. Hypophysis. Epiphysis. Urophysis Immunoassay - methods Immunoassay - standards Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Polyethylene Glycols - pharmacology Prolactin - blood Solvents - pharmacology Vertebrates: endocrinology
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