MnDPDP enhanced Magnetic Resonance Imaging of Focal Liver Lesions
Mangafodipir trisodium (MnDPDP) is a contrast agent for use in magnetic resonance imaging (MRI) of the liver. The agent is taken up by normal hepatocytes resulting in increased signal on T1-weighted imaging, and is excreted in the biliary system. Hepatocyte-containing liver neoplasms such as hepatom...
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| Veröffentlicht in: | Clinical Radiology 2002-12, Vol.57 (12), p.1047-1057 |
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| container_title | Clinical Radiology |
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| creator | King, L.J Burkill, G.J.C Scurr, E.D Vlavianos, P Murray-Lyons, I Healy, J.C |
| description | Mangafodipir trisodium (MnDPDP) is a contrast agent for use in magnetic resonance imaging (MRI) of the liver. The agent is taken up by normal hepatocytes resulting in increased signal on T1-weighted imaging, and is excreted in the biliary system. Hepatocyte-containing liver neoplasms such as hepatomas or focal nodular hyperplasia (FNH), take up MnDPDP and demonstrate varying degrees of enhancement. Metastatic liver deposits and primary liver tumours of non-hepatocyte origin do not typically enhance with MnDPDP thus increasing their conspicuity compared with pre-contrast T1-weighted images. Metastases may demonstrate rim enhancement particularly on delayed imaging at 24 h, which can increase their conspicuity, thus allowing better visualization of small lesions. Functional biliary obstruction due to liver metastases can also result in wedge shaped areas of parenchymal enhancement.
The MRI features of various focal liver after continuance with lesions following MnDPDP are discussed and illustrated including primary lesions such as hepatoma and secondary metastases. King, L. J. et al. (2002). Clinical Radiology57, 1047–1057. |
| doi_str_mv | 10.1053/crad.2002.1117 |
| format | Article |
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The MRI features of various focal liver after continuance with lesions following MnDPDP are discussed and illustrated including primary lesions such as hepatoma and secondary metastases. King, L. J. et al. (2002). Clinical Radiology57, 1047–1057.</description><identifier>ISSN: 0009-9260</identifier><identifier>EISSN: 1365-229X</identifier><identifier>DOI: 10.1053/crad.2002.1117</identifier><identifier>PMID: 12475527</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adenoma, Liver Cell - diagnosis ; Adult ; Aged ; Cholangiocarcinoma - diagnosis ; Contrast Media ; Edetic Acid - analogs & derivatives ; Female ; Focal Nodular Hyperplasia - diagnosis ; Hemangioma - diagnosis ; Humans ; Liver Diseases - diagnosis ; Liver Neoplasms - diagnosis ; Liver Neoplasms - secondary ; liver, MRI, MnDPDP ; Magnetic Resonance Imaging - methods ; Magnetic Resonance Imaging - standards ; Male ; Middle Aged ; Pyridoxal Phosphate - analogs & derivatives</subject><ispartof>Clinical Radiology, 2002-12, Vol.57 (12), p.1047-1057</ispartof><rights>2002 The Royal College of Radiologists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c340t-b043c63e14bfdefa5589d91d93bb08b7fde88406a85f845772884691b0c362c63</citedby><cites>FETCH-LOGICAL-c340t-b043c63e14bfdefa5589d91d93bb08b7fde88406a85f845772884691b0c362c63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0009926002911177$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>313,314,776,780,788,3537,27899,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12475527$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>King, L.J</creatorcontrib><creatorcontrib>Burkill, G.J.C</creatorcontrib><creatorcontrib>Scurr, E.D</creatorcontrib><creatorcontrib>Vlavianos, P</creatorcontrib><creatorcontrib>Murray-Lyons, I</creatorcontrib><creatorcontrib>Healy, J.C</creatorcontrib><title>MnDPDP enhanced Magnetic Resonance Imaging of Focal Liver Lesions</title><title>Clinical Radiology</title><addtitle>Clin Radiol</addtitle><description>Mangafodipir trisodium (MnDPDP) is a contrast agent for use in magnetic resonance imaging (MRI) of the liver. The agent is taken up by normal hepatocytes resulting in increased signal on T1-weighted imaging, and is excreted in the biliary system. Hepatocyte-containing liver neoplasms such as hepatomas or focal nodular hyperplasia (FNH), take up MnDPDP and demonstrate varying degrees of enhancement. Metastatic liver deposits and primary liver tumours of non-hepatocyte origin do not typically enhance with MnDPDP thus increasing their conspicuity compared with pre-contrast T1-weighted images. Metastases may demonstrate rim enhancement particularly on delayed imaging at 24 h, which can increase their conspicuity, thus allowing better visualization of small lesions. Functional biliary obstruction due to liver metastases can also result in wedge shaped areas of parenchymal enhancement.
The MRI features of various focal liver after continuance with lesions following MnDPDP are discussed and illustrated including primary lesions such as hepatoma and secondary metastases. King, L. J. et al. (2002). Clinical Radiology57, 1047–1057.</description><subject>Adenoma, Liver Cell - diagnosis</subject><subject>Adult</subject><subject>Aged</subject><subject>Cholangiocarcinoma - diagnosis</subject><subject>Contrast Media</subject><subject>Edetic Acid - analogs & derivatives</subject><subject>Female</subject><subject>Focal Nodular Hyperplasia - diagnosis</subject><subject>Hemangioma - diagnosis</subject><subject>Humans</subject><subject>Liver Diseases - diagnosis</subject><subject>Liver Neoplasms - diagnosis</subject><subject>Liver Neoplasms - secondary</subject><subject>liver, MRI, MnDPDP</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Magnetic Resonance Imaging - standards</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pyridoxal Phosphate - analogs & derivatives</subject><issn>0009-9260</issn><issn>1365-229X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM9LwzAUx4Mobk6vHiUnb6350TTtcWxOBxsOUfAW0vR1RtpmJt3A_96WDTx5erzH5_uF90HolpKYEsEfjNdlzAhhMaVUnqEx5amIGMs_ztGYEJJHOUvJCF2F8DWsCUsu0YiyRArB5BhN1-18M99gaD91a6DEa71tobMGv0Jw7XDDy0ZvbbvFrsILZ3SNV_YAHq8gWNeGa3RR6TrAzWlO0Pvi8W32HK1enpaz6SoyPCFdVJCEm5QDTYqqhEoLkeVlTsucFwXJCtkfsywhqc5ElSVCStavaU4LYnjK-uQE3R97d9597yF0qrHBQF3rFtw-KMmkkJyTHoyPoPEuBA-V2nnbaP-jKFGDNDVIU4M0NUjrA3en5n3RQPmHnyz1QHYEoP_vYMGrYCwMuqwH06nS2f-6fwFaqHlS</recordid><startdate>200212</startdate><enddate>200212</enddate><creator>King, L.J</creator><creator>Burkill, G.J.C</creator><creator>Scurr, E.D</creator><creator>Vlavianos, P</creator><creator>Murray-Lyons, I</creator><creator>Healy, J.C</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200212</creationdate><title>MnDPDP enhanced Magnetic Resonance Imaging of Focal Liver Lesions</title><author>King, L.J ; Burkill, G.J.C ; Scurr, E.D ; Vlavianos, P ; Murray-Lyons, I ; Healy, J.C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c340t-b043c63e14bfdefa5589d91d93bb08b7fde88406a85f845772884691b0c362c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adenoma, Liver Cell - diagnosis</topic><topic>Adult</topic><topic>Aged</topic><topic>Cholangiocarcinoma - diagnosis</topic><topic>Contrast Media</topic><topic>Edetic Acid - analogs & derivatives</topic><topic>Female</topic><topic>Focal Nodular Hyperplasia - diagnosis</topic><topic>Hemangioma - diagnosis</topic><topic>Humans</topic><topic>Liver Diseases - diagnosis</topic><topic>Liver Neoplasms - diagnosis</topic><topic>Liver Neoplasms - secondary</topic><topic>liver, MRI, MnDPDP</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Magnetic Resonance Imaging - standards</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pyridoxal Phosphate - analogs & derivatives</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>King, L.J</creatorcontrib><creatorcontrib>Burkill, G.J.C</creatorcontrib><creatorcontrib>Scurr, E.D</creatorcontrib><creatorcontrib>Vlavianos, P</creatorcontrib><creatorcontrib>Murray-Lyons, I</creatorcontrib><creatorcontrib>Healy, J.C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical Radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>King, L.J</au><au>Burkill, G.J.C</au><au>Scurr, E.D</au><au>Vlavianos, P</au><au>Murray-Lyons, I</au><au>Healy, J.C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MnDPDP enhanced Magnetic Resonance Imaging of Focal Liver Lesions</atitle><jtitle>Clinical Radiology</jtitle><addtitle>Clin Radiol</addtitle><date>2002-12</date><risdate>2002</risdate><volume>57</volume><issue>12</issue><spage>1047</spage><epage>1057</epage><pages>1047-1057</pages><issn>0009-9260</issn><eissn>1365-229X</eissn><abstract>Mangafodipir trisodium (MnDPDP) is a contrast agent for use in magnetic resonance imaging (MRI) of the liver. The agent is taken up by normal hepatocytes resulting in increased signal on T1-weighted imaging, and is excreted in the biliary system. Hepatocyte-containing liver neoplasms such as hepatomas or focal nodular hyperplasia (FNH), take up MnDPDP and demonstrate varying degrees of enhancement. Metastatic liver deposits and primary liver tumours of non-hepatocyte origin do not typically enhance with MnDPDP thus increasing their conspicuity compared with pre-contrast T1-weighted images. Metastases may demonstrate rim enhancement particularly on delayed imaging at 24 h, which can increase their conspicuity, thus allowing better visualization of small lesions. Functional biliary obstruction due to liver metastases can also result in wedge shaped areas of parenchymal enhancement.
The MRI features of various focal liver after continuance with lesions following MnDPDP are discussed and illustrated including primary lesions such as hepatoma and secondary metastases. King, L. J. et al. (2002). Clinical Radiology57, 1047–1057.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>12475527</pmid><doi>10.1053/crad.2002.1117</doi><tpages>11</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adenoma, Liver Cell - diagnosis Adult Aged Cholangiocarcinoma - diagnosis Contrast Media Edetic Acid - analogs & derivatives Female Focal Nodular Hyperplasia - diagnosis Hemangioma - diagnosis Humans Liver Diseases - diagnosis Liver Neoplasms - diagnosis Liver Neoplasms - secondary liver, MRI, MnDPDP Magnetic Resonance Imaging - methods Magnetic Resonance Imaging - standards Male Middle Aged Pyridoxal Phosphate - analogs & derivatives |
| title | MnDPDP enhanced Magnetic Resonance Imaging of Focal Liver Lesions |
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