Cyclooxygenase-pathway participates in the regulation of regional cerebral blood flow in response to neuronal activation under normo- and hypercapnia
The present study was designed to investigate whether cyclooxygenase products are involved in the regulation of the regional cerebral blood flow, evoked by somatosensory activation (evoked rCBF) under normo- and hypercapnia. Indomethacin (IMC) was used as cyclooxygenase inhibitor. It was applied int...
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| Veröffentlicht in: | Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2002-12, Vol.67 (6), p.379-388 |
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| creator | Bakalova, R.A. Matsuura, T. Kanno, I. |
| description | The present study was designed to investigate whether cyclooxygenase products are involved in the regulation of the regional cerebral blood flow, evoked by somatosensory activation (evoked rCBF) under normo- and hypercapnia. Indomethacin (IMC) was used as cyclooxygenase inhibitor. It was applied intravenously (i.v., 10 mg/kg/h) in two experimental protocols—before hypercapnia (i) and after hypercapnia (ii). Somatosensory activation was induced by electrical hind paw stimulation (5 Hz frequency, 5 s duration, 1.5 mA). The evoked rCBF-response was measured in
α -chloralose anesthetized rats using laser-Doppler flowmetry. IMC abolished completely the effect of hypercapnia on the baseline level of CBF. The drug reduced significantly evoked rCBF-response also. The inhibitory effect of IMC on evoked rCBF-response is better expressed under normocapnia (∼70%) than that under hypercapnia (∼40%). After IMC application, the normalized evoked rCBF curves peaked earlier as compared to that before its application (
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| doi_str_mv | 10.1054/plef.2002.0445 |
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α -chloralose anesthetized rats using laser-Doppler flowmetry. IMC abolished completely the effect of hypercapnia on the baseline level of CBF. The drug reduced significantly evoked rCBF-response also. The inhibitory effect of IMC on evoked rCBF-response is better expressed under normocapnia (∼70%) than that under hypercapnia (∼40%). After IMC application, the normalized evoked rCBF curves peaked earlier as compared to that before its application (
P<0.05), although the rise time of 0.5 s was nearly constant regardless of stimulus frequency. In conclusion, the results suggest a participation of IMC-sensitive and cyclooxygenase-dependent mechanisms in the regulation of evoked rCBF, induced by somatosensory stimulation.</description><identifier>ISSN: 0952-3278</identifier><identifier>EISSN: 1532-2823</identifier><identifier>DOI: 10.1054/plef.2002.0445</identifier><identifier>PMID: 12468258</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Acid-Base Equilibrium ; Animals ; Biological and medical sciences ; Blood Flow Velocity ; Blood Pressure ; Carbon Dioxide - metabolism ; Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges ; Cerebral Cortex - blood supply ; Cerebrovascular Circulation - physiology ; Cyclooxygenase Inhibitors - pharmacology ; Fundamental and applied biological sciences. Psychology ; Hypercapnia - enzymology ; Hypercapnia - physiopathology ; Indomethacin - pharmacology ; Male ; Neurons - physiology ; Prostaglandin-Endoperoxide Synthases - metabolism ; Rats ; Rats, Sprague-Dawley ; Regional Blood Flow ; Vertebrates: nervous system and sense organs</subject><ispartof>Prostaglandins, leukotrienes and essential fatty acids, 2002-12, Vol.67 (6), p.379-388</ispartof><rights>2002 Elsevier Science Ltd</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-a0aeabfb42d9b3d1b2def30d4a811901efcb5aa2d35b8e2754481a2f6cd1c37e3</citedby><cites>FETCH-LOGICAL-c370t-a0aeabfb42d9b3d1b2def30d4a811901efcb5aa2d35b8e2754481a2f6cd1c37e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S095232780290445X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14043454$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12468258$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bakalova, R.A.</creatorcontrib><creatorcontrib>Matsuura, T.</creatorcontrib><creatorcontrib>Kanno, I.</creatorcontrib><title>Cyclooxygenase-pathway participates in the regulation of regional cerebral blood flow in response to neuronal activation under normo- and hypercapnia</title><title>Prostaglandins, leukotrienes and essential fatty acids</title><addtitle>Prostaglandins Leukot Essent Fatty Acids</addtitle><description>The present study was designed to investigate whether cyclooxygenase products are involved in the regulation of the regional cerebral blood flow, evoked by somatosensory activation (evoked rCBF) under normo- and hypercapnia. Indomethacin (IMC) was used as cyclooxygenase inhibitor. It was applied intravenously (i.v., 10 mg/kg/h) in two experimental protocols—before hypercapnia (i) and after hypercapnia (ii). Somatosensory activation was induced by electrical hind paw stimulation (5 Hz frequency, 5 s duration, 1.5 mA). The evoked rCBF-response was measured in
α -chloralose anesthetized rats using laser-Doppler flowmetry. IMC abolished completely the effect of hypercapnia on the baseline level of CBF. The drug reduced significantly evoked rCBF-response also. The inhibitory effect of IMC on evoked rCBF-response is better expressed under normocapnia (∼70%) than that under hypercapnia (∼40%). After IMC application, the normalized evoked rCBF curves peaked earlier as compared to that before its application (
P<0.05), although the rise time of 0.5 s was nearly constant regardless of stimulus frequency. In conclusion, the results suggest a participation of IMC-sensitive and cyclooxygenase-dependent mechanisms in the regulation of evoked rCBF, induced by somatosensory stimulation.</description><subject>Acid-Base Equilibrium</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Flow Velocity</subject><subject>Blood Pressure</subject><subject>Carbon Dioxide - metabolism</subject><subject>Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges</subject><subject>Cerebral Cortex - blood supply</subject><subject>Cerebrovascular Circulation - physiology</subject><subject>Cyclooxygenase Inhibitors - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hypercapnia - enzymology</subject><subject>Hypercapnia - physiopathology</subject><subject>Indomethacin - pharmacology</subject><subject>Male</subject><subject>Neurons - physiology</subject><subject>Prostaglandin-Endoperoxide Synthases - metabolism</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Regional Blood Flow</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0952-3278</issn><issn>1532-2823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1v1DAQhi1ERZfClSPyhd6y9WeTPaIVFKRKXOBsTexx1yhrBztpyQ_h_-KwK_XEyTPS8z6y5iXkHWdbzrS6GQf0W8GY2DKl9Auy4VqKRnRCviQbttOikaLtLsnrUn6yinGuXpFLLtRtJ3S3IX_2ix1S-r08YISCzQjT4QkWOkKegg11xUJDpNMBacaHeYAppEiTX7c6wUAtZuxzHfoqctQP6WlNZCxjigXplGjEOf9jwU7h8aSYo8NMY8rH1FCIjh6WEbOFMQZ4Qy48DAXfnt8r8uPzp-_7L839t7uv-4_3jZUtmxpggND7Xgm366XjvXDoJXMKOs53jKO3vQYQTuq-Q9FqpToOwt9ax6sB5RW5PnnHnH7NWCZzDMXiMEDENBfT1kzLpa7g9gTanErJ6M2YwxHyYjgzaxFmLcKsRZi1iBp4fzbP_RHdM36-fAU-nAEoFgafIdpQnjnFlFRaVa47cVjv8Bgwm2IDRosuZLSTcSn87w9_ATk0qWA</recordid><startdate>20021201</startdate><enddate>20021201</enddate><creator>Bakalova, R.A.</creator><creator>Matsuura, T.</creator><creator>Kanno, I.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021201</creationdate><title>Cyclooxygenase-pathway participates in the regulation of regional cerebral blood flow in response to neuronal activation under normo- and hypercapnia</title><author>Bakalova, R.A. ; Matsuura, T. ; Kanno, I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-a0aeabfb42d9b3d1b2def30d4a811901efcb5aa2d35b8e2754481a2f6cd1c37e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Acid-Base Equilibrium</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Flow Velocity</topic><topic>Blood Pressure</topic><topic>Carbon Dioxide - metabolism</topic><topic>Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges</topic><topic>Cerebral Cortex - blood supply</topic><topic>Cerebrovascular Circulation - physiology</topic><topic>Cyclooxygenase Inhibitors - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hypercapnia - enzymology</topic><topic>Hypercapnia - physiopathology</topic><topic>Indomethacin - pharmacology</topic><topic>Male</topic><topic>Neurons - physiology</topic><topic>Prostaglandin-Endoperoxide Synthases - metabolism</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Regional Blood Flow</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bakalova, R.A.</creatorcontrib><creatorcontrib>Matsuura, T.</creatorcontrib><creatorcontrib>Kanno, I.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Prostaglandins, leukotrienes and essential fatty acids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bakalova, R.A.</au><au>Matsuura, T.</au><au>Kanno, I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cyclooxygenase-pathway participates in the regulation of regional cerebral blood flow in response to neuronal activation under normo- and hypercapnia</atitle><jtitle>Prostaglandins, leukotrienes and essential fatty acids</jtitle><addtitle>Prostaglandins Leukot Essent Fatty Acids</addtitle><date>2002-12-01</date><risdate>2002</risdate><volume>67</volume><issue>6</issue><spage>379</spage><epage>388</epage><pages>379-388</pages><issn>0952-3278</issn><eissn>1532-2823</eissn><abstract>The present study was designed to investigate whether cyclooxygenase products are involved in the regulation of the regional cerebral blood flow, evoked by somatosensory activation (evoked rCBF) under normo- and hypercapnia. Indomethacin (IMC) was used as cyclooxygenase inhibitor. It was applied intravenously (i.v., 10 mg/kg/h) in two experimental protocols—before hypercapnia (i) and after hypercapnia (ii). Somatosensory activation was induced by electrical hind paw stimulation (5 Hz frequency, 5 s duration, 1.5 mA). The evoked rCBF-response was measured in
α -chloralose anesthetized rats using laser-Doppler flowmetry. IMC abolished completely the effect of hypercapnia on the baseline level of CBF. The drug reduced significantly evoked rCBF-response also. The inhibitory effect of IMC on evoked rCBF-response is better expressed under normocapnia (∼70%) than that under hypercapnia (∼40%). After IMC application, the normalized evoked rCBF curves peaked earlier as compared to that before its application (
P<0.05), although the rise time of 0.5 s was nearly constant regardless of stimulus frequency. In conclusion, the results suggest a participation of IMC-sensitive and cyclooxygenase-dependent mechanisms in the regulation of evoked rCBF, induced by somatosensory stimulation.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>12468258</pmid><doi>10.1054/plef.2002.0445</doi><tpages>10</tpages></addata></record> |
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| subjects | Acid-Base Equilibrium Animals Biological and medical sciences Blood Flow Velocity Blood Pressure Carbon Dioxide - metabolism Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Cerebral Cortex - blood supply Cerebrovascular Circulation - physiology Cyclooxygenase Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Hypercapnia - enzymology Hypercapnia - physiopathology Indomethacin - pharmacology Male Neurons - physiology Prostaglandin-Endoperoxide Synthases - metabolism Rats Rats, Sprague-Dawley Regional Blood Flow Vertebrates: nervous system and sense organs |
| title | Cyclooxygenase-pathway participates in the regulation of regional cerebral blood flow in response to neuronal activation under normo- and hypercapnia |
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