Right ventricular function in adults with repaired tetralogy of Fallot assessed with cardiovascular magnetic resonance imaging: Detrimental role of right ventricular outflow aneurysms or akinesia and adverse right-to-left ventricular interaction

We examined the relationship among biventricular hemodynamics, pulmonary regurgitant fraction (PRF), right ventricular outflow tract (RVOT) aneurysm or akinesia, and baseline and surgical characteristics in adults with repaired tetralogy of Fallot (rTOF). The precise relationship of pulmonary regurg...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of the American College of Cardiology 2002-12, Vol.40 (11), p.2044-2052
Hauptverfasser: DAVLOUROS, Periklis A, KILNER, Philip J, HORNUNG, Tim S, WEI LI, FRANCIS, Jane M, MOON, James C. C, SMITH, Gillian C, TAT, Tri, PENNELL, Dudley J, GATZOULIS, Michael A
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 2052
container_issue 11
container_start_page 2044
container_title Journal of the American College of Cardiology
container_volume 40
creator DAVLOUROS, Periklis A
KILNER, Philip J
HORNUNG, Tim S
WEI LI
FRANCIS, Jane M
MOON, James C. C
SMITH, Gillian C
TAT, Tri
PENNELL, Dudley J
GATZOULIS, Michael A
description We examined the relationship among biventricular hemodynamics, pulmonary regurgitant fraction (PRF), right ventricular outflow tract (RVOT) aneurysm or akinesia, and baseline and surgical characteristics in adults with repaired tetralogy of Fallot (rTOF). The precise relationship of pulmonary regurgitation with biventricular hemodynamics has been hampered by limitations of right ventricular (RV) imaging. We assessed 85 consecutive adults with rTOF and 26 matched healthy controls using cardiovascular magnetic resonance imaging. Patients had higher right ventricular end-diastolic volume index (RVEDVi) (p < 0.001), right ventricular end-systolic volume index (RVESVi) (p < 0.001), right ventricular mass index (RVMi) (p < 0.001), and lower right ventricular ejection fraction (RVEF) (p < 0.001) and left ventricular ejection fraction (LVEF) (p = 0.002) compared to controls. The PRF (range 0% to 55%) independently predicted RVEDVi (p < 0.01) and the latter predicted RVESVi (p < 0.01) and RVMi (p < 0.01). The RVOT aneurysm/akinesia was present in 48/85 (56.9%) of patients and predicted RV volumes (RVEDVi, p = 0.01, and RVESVi, p = 0.03). There was a negative effect of RVOT aneurysm/akinesia and RVMi on RVEF (p < 0.01 and p = 0.02, respectively). There was only a tendency among patients with transannular or RVOT patching toward RVOT aneurysm/akinesia (p = 0.09). The LVEF correlated with RVEF (r = 0.67, p < 0.001). Pulmonary regurgitation and RVOT aneurysm/akinesia were independently associated with RV dilation and the latter with RV hypertrophy late after rTOF. The RVOT aneurysm/akinesia was common but related only in part to RVOT or transannular patching. Both RV hypertrophy and RVOT aneurysm/akinesia were associated with lower RVEF. Left ventricular systolic dysfunction correlated with RV dysfunction, suggesting an unfavorable ventricular-ventricular interaction. Measures to maintain or restore pulmonary valve function and avoid RVOT aneurysm/akinesia are mandatory for preserving biventricular function late after rTOF.
doi_str_mv 10.1016/S0735-1097(02)02566-4
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_72756387</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72756387</sourcerecordid><originalsourceid>FETCH-LOGICAL-c353t-1121d096f33ba1d2dd793ba88e0c6d701effe21c8403eed178bd1c4052db9d193</originalsourceid><addsrcrecordid>eNplke2LVCEUhyWKdtr6EwohivpwS6_Xl9u32NoKFoJePl8cPc66eXVS7yzzh_c9a6aiAkE5PD7-zhGh-5Q8o4SK5x-JZLyjZJRPSP-U9FyIbriBVpRz1TE-ypto9Rs5QXdKuSKECEXH2-iE9oPkg1Ar9O2D31xWvINYszdL0Bm7JZrqU8Q-Ym2XUAu-9vUSZ9hqn8HiCjXrkDZ7nBw-1yGkinUp0JY9oEZn69NOl4Nx1psI1ZumKCnqaAD7VvNx8wK_ajI_t-d1wDkF-OHM_2VKS3UhXWMdYcn7MhecMtZffITidavalnQHucDhbldTF8D97fCxQtY_W7uLbjkdCtw77qfo8_nrT2dvu4v3b96dvbzoDOOsdpT21JJROMbWmtreWjm2k1JAjLCSUHAOemrUQBiApVKtLTUD4b1dj5aO7BQ9Pni3OX1doNRp9sVACK2PtJRJ9pILpmQDH_4DXqUlx5ZtopwI2o9cqkY9OFLLegY7bdvkdN5Pv76zAY-OQBu9Di63WfvyhxuY4oMS7DvVhLhG</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1506129578</pqid></control><display><type>article</type><title>Right ventricular function in adults with repaired tetralogy of Fallot assessed with cardiovascular magnetic resonance imaging: Detrimental role of right ventricular outflow aneurysms or akinesia and adverse right-to-left ventricular interaction</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>DAVLOUROS, Periklis A ; KILNER, Philip J ; HORNUNG, Tim S ; WEI LI ; FRANCIS, Jane M ; MOON, James C. C ; SMITH, Gillian C ; TAT, Tri ; PENNELL, Dudley J ; GATZOULIS, Michael A</creator><creatorcontrib>DAVLOUROS, Periklis A ; KILNER, Philip J ; HORNUNG, Tim S ; WEI LI ; FRANCIS, Jane M ; MOON, James C. C ; SMITH, Gillian C ; TAT, Tri ; PENNELL, Dudley J ; GATZOULIS, Michael A</creatorcontrib><description><![CDATA[We examined the relationship among biventricular hemodynamics, pulmonary regurgitant fraction (PRF), right ventricular outflow tract (RVOT) aneurysm or akinesia, and baseline and surgical characteristics in adults with repaired tetralogy of Fallot (rTOF). The precise relationship of pulmonary regurgitation with biventricular hemodynamics has been hampered by limitations of right ventricular (RV) imaging. We assessed 85 consecutive adults with rTOF and 26 matched healthy controls using cardiovascular magnetic resonance imaging. Patients had higher right ventricular end-diastolic volume index (RVEDVi) (p < 0.001), right ventricular end-systolic volume index (RVESVi) (p < 0.001), right ventricular mass index (RVMi) (p < 0.001), and lower right ventricular ejection fraction (RVEF) (p < 0.001) and left ventricular ejection fraction (LVEF) (p = 0.002) compared to controls. The PRF (range 0% to 55%) independently predicted RVEDVi (p < 0.01) and the latter predicted RVESVi (p < 0.01) and RVMi (p < 0.01). The RVOT aneurysm/akinesia was present in 48/85 (56.9%) of patients and predicted RV volumes (RVEDVi, p = 0.01, and RVESVi, p = 0.03). There was a negative effect of RVOT aneurysm/akinesia and RVMi on RVEF (p < 0.01 and p = 0.02, respectively). There was only a tendency among patients with transannular or RVOT patching toward RVOT aneurysm/akinesia (p = 0.09). The LVEF correlated with RVEF (r = 0.67, p < 0.001). Pulmonary regurgitation and RVOT aneurysm/akinesia were independently associated with RV dilation and the latter with RV hypertrophy late after rTOF. The RVOT aneurysm/akinesia was common but related only in part to RVOT or transannular patching. Both RV hypertrophy and RVOT aneurysm/akinesia were associated with lower RVEF. Left ventricular systolic dysfunction correlated with RV dysfunction, suggesting an unfavorable ventricular-ventricular interaction. Measures to maintain or restore pulmonary valve function and avoid RVOT aneurysm/akinesia are mandatory for preserving biventricular function late after rTOF.]]></description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/S0735-1097(02)02566-4</identifier><identifier>PMID: 12475468</identifier><identifier>CODEN: JACCDI</identifier><language>eng</language><publisher>New York, NY: Elsevier Science</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Cardiology ; Cardiology. Vascular system ; Cardiovascular Surgical Procedures ; Confidence intervals ; Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava ; Diagnostic Techniques, Cardiovascular ; Dyskinesias - diagnosis ; Dyskinesias - physiopathology ; Dyskinesias - surgery ; Female ; Heart ; Heart Aneurysm - diagnosis ; Heart Aneurysm - physiopathology ; Heart Aneurysm - surgery ; Heart attacks ; Heart Ventricles - diagnostic imaging ; Heart Ventricles - physiopathology ; Heart Ventricles - surgery ; Humans ; London ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Middle Aged ; Mortality ; Predictive Value of Tests ; Prospective Studies ; Pulmonary arteries ; Pulmonary Valve Insufficiency - complications ; Pulmonary Valve Insufficiency - diagnosis ; Pulmonary Valve Insufficiency - surgery ; Pulmonary Valve Stenosis - complications ; Pulmonary Valve Stenosis - diagnosis ; Pulmonary Valve Stenosis - physiopathology ; Severity of Illness Index ; Stroke Volume - physiology ; Tetralogy of Fallot - diagnosis ; Tetralogy of Fallot - physiopathology ; Tetralogy of Fallot - surgery ; Treatment Outcome ; Ultrasonography ; Veins &amp; arteries ; Ventricular Function, Right - physiology ; Ventricular Outflow Obstruction - diagnosis ; Ventricular Outflow Obstruction - physiopathology ; Ventricular Outflow Obstruction - surgery</subject><ispartof>Journal of the American College of Cardiology, 2002-12, Vol.40 (11), p.2044-2052</ispartof><rights>2003 INIST-CNRS</rights><rights>Copyright Elsevier Limited Dec 4, 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-1121d096f33ba1d2dd793ba88e0c6d701effe21c8403eed178bd1c4052db9d193</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=14385486$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12475468$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DAVLOUROS, Periklis A</creatorcontrib><creatorcontrib>KILNER, Philip J</creatorcontrib><creatorcontrib>HORNUNG, Tim S</creatorcontrib><creatorcontrib>WEI LI</creatorcontrib><creatorcontrib>FRANCIS, Jane M</creatorcontrib><creatorcontrib>MOON, James C. C</creatorcontrib><creatorcontrib>SMITH, Gillian C</creatorcontrib><creatorcontrib>TAT, Tri</creatorcontrib><creatorcontrib>PENNELL, Dudley J</creatorcontrib><creatorcontrib>GATZOULIS, Michael A</creatorcontrib><title>Right ventricular function in adults with repaired tetralogy of Fallot assessed with cardiovascular magnetic resonance imaging: Detrimental role of right ventricular outflow aneurysms or akinesia and adverse right-to-left ventricular interaction</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description><![CDATA[We examined the relationship among biventricular hemodynamics, pulmonary regurgitant fraction (PRF), right ventricular outflow tract (RVOT) aneurysm or akinesia, and baseline and surgical characteristics in adults with repaired tetralogy of Fallot (rTOF). The precise relationship of pulmonary regurgitation with biventricular hemodynamics has been hampered by limitations of right ventricular (RV) imaging. We assessed 85 consecutive adults with rTOF and 26 matched healthy controls using cardiovascular magnetic resonance imaging. Patients had higher right ventricular end-diastolic volume index (RVEDVi) (p < 0.001), right ventricular end-systolic volume index (RVESVi) (p < 0.001), right ventricular mass index (RVMi) (p < 0.001), and lower right ventricular ejection fraction (RVEF) (p < 0.001) and left ventricular ejection fraction (LVEF) (p = 0.002) compared to controls. The PRF (range 0% to 55%) independently predicted RVEDVi (p < 0.01) and the latter predicted RVESVi (p < 0.01) and RVMi (p < 0.01). The RVOT aneurysm/akinesia was present in 48/85 (56.9%) of patients and predicted RV volumes (RVEDVi, p = 0.01, and RVESVi, p = 0.03). There was a negative effect of RVOT aneurysm/akinesia and RVMi on RVEF (p < 0.01 and p = 0.02, respectively). There was only a tendency among patients with transannular or RVOT patching toward RVOT aneurysm/akinesia (p = 0.09). The LVEF correlated with RVEF (r = 0.67, p < 0.001). Pulmonary regurgitation and RVOT aneurysm/akinesia were independently associated with RV dilation and the latter with RV hypertrophy late after rTOF. The RVOT aneurysm/akinesia was common but related only in part to RVOT or transannular patching. Both RV hypertrophy and RVOT aneurysm/akinesia were associated with lower RVEF. Left ventricular systolic dysfunction correlated with RV dysfunction, suggesting an unfavorable ventricular-ventricular interaction. Measures to maintain or restore pulmonary valve function and avoid RVOT aneurysm/akinesia are mandatory for preserving biventricular function late after rTOF.]]></description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cardiology</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular Surgical Procedures</subject><subject>Confidence intervals</subject><subject>Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava</subject><subject>Diagnostic Techniques, Cardiovascular</subject><subject>Dyskinesias - diagnosis</subject><subject>Dyskinesias - physiopathology</subject><subject>Dyskinesias - surgery</subject><subject>Female</subject><subject>Heart</subject><subject>Heart Aneurysm - diagnosis</subject><subject>Heart Aneurysm - physiopathology</subject><subject>Heart Aneurysm - surgery</subject><subject>Heart attacks</subject><subject>Heart Ventricles - diagnostic imaging</subject><subject>Heart Ventricles - physiopathology</subject><subject>Heart Ventricles - surgery</subject><subject>Humans</subject><subject>London</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Predictive Value of Tests</subject><subject>Prospective Studies</subject><subject>Pulmonary arteries</subject><subject>Pulmonary Valve Insufficiency - complications</subject><subject>Pulmonary Valve Insufficiency - diagnosis</subject><subject>Pulmonary Valve Insufficiency - surgery</subject><subject>Pulmonary Valve Stenosis - complications</subject><subject>Pulmonary Valve Stenosis - diagnosis</subject><subject>Pulmonary Valve Stenosis - physiopathology</subject><subject>Severity of Illness Index</subject><subject>Stroke Volume - physiology</subject><subject>Tetralogy of Fallot - diagnosis</subject><subject>Tetralogy of Fallot - physiopathology</subject><subject>Tetralogy of Fallot - surgery</subject><subject>Treatment Outcome</subject><subject>Ultrasonography</subject><subject>Veins &amp; arteries</subject><subject>Ventricular Function, Right - physiology</subject><subject>Ventricular Outflow Obstruction - diagnosis</subject><subject>Ventricular Outflow Obstruction - physiopathology</subject><subject>Ventricular Outflow Obstruction - surgery</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplke2LVCEUhyWKdtr6EwohivpwS6_Xl9u32NoKFoJePl8cPc66eXVS7yzzh_c9a6aiAkE5PD7-zhGh-5Q8o4SK5x-JZLyjZJRPSP-U9FyIbriBVpRz1TE-ypto9Rs5QXdKuSKECEXH2-iE9oPkg1Ar9O2D31xWvINYszdL0Bm7JZrqU8Q-Ym2XUAu-9vUSZ9hqn8HiCjXrkDZ7nBw-1yGkinUp0JY9oEZn69NOl4Nx1psI1ZumKCnqaAD7VvNx8wK_ajI_t-d1wDkF-OHM_2VKS3UhXWMdYcn7MhecMtZffITidavalnQHucDhbldTF8D97fCxQtY_W7uLbjkdCtw77qfo8_nrT2dvu4v3b96dvbzoDOOsdpT21JJROMbWmtreWjm2k1JAjLCSUHAOemrUQBiApVKtLTUD4b1dj5aO7BQ9Pni3OX1doNRp9sVACK2PtJRJ9pILpmQDH_4DXqUlx5ZtopwI2o9cqkY9OFLLegY7bdvkdN5Pv76zAY-OQBu9Di63WfvyhxuY4oMS7DvVhLhG</recordid><startdate>20021204</startdate><enddate>20021204</enddate><creator>DAVLOUROS, Periklis A</creator><creator>KILNER, Philip J</creator><creator>HORNUNG, Tim S</creator><creator>WEI LI</creator><creator>FRANCIS, Jane M</creator><creator>MOON, James C. C</creator><creator>SMITH, Gillian C</creator><creator>TAT, Tri</creator><creator>PENNELL, Dudley J</creator><creator>GATZOULIS, Michael A</creator><general>Elsevier Science</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20021204</creationdate><title>Right ventricular function in adults with repaired tetralogy of Fallot assessed with cardiovascular magnetic resonance imaging: Detrimental role of right ventricular outflow aneurysms or akinesia and adverse right-to-left ventricular interaction</title><author>DAVLOUROS, Periklis A ; KILNER, Philip J ; HORNUNG, Tim S ; WEI LI ; FRANCIS, Jane M ; MOON, James C. C ; SMITH, Gillian C ; TAT, Tri ; PENNELL, Dudley J ; GATZOULIS, Michael A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-1121d096f33ba1d2dd793ba88e0c6d701effe21c8403eed178bd1c4052db9d193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cardiology</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular Surgical Procedures</topic><topic>Confidence intervals</topic><topic>Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava</topic><topic>Diagnostic Techniques, Cardiovascular</topic><topic>Dyskinesias - diagnosis</topic><topic>Dyskinesias - physiopathology</topic><topic>Dyskinesias - surgery</topic><topic>Female</topic><topic>Heart</topic><topic>Heart Aneurysm - diagnosis</topic><topic>Heart Aneurysm - physiopathology</topic><topic>Heart Aneurysm - surgery</topic><topic>Heart attacks</topic><topic>Heart Ventricles - diagnostic imaging</topic><topic>Heart Ventricles - physiopathology</topic><topic>Heart Ventricles - surgery</topic><topic>Humans</topic><topic>London</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Predictive Value of Tests</topic><topic>Prospective Studies</topic><topic>Pulmonary arteries</topic><topic>Pulmonary Valve Insufficiency - complications</topic><topic>Pulmonary Valve Insufficiency - diagnosis</topic><topic>Pulmonary Valve Insufficiency - surgery</topic><topic>Pulmonary Valve Stenosis - complications</topic><topic>Pulmonary Valve Stenosis - diagnosis</topic><topic>Pulmonary Valve Stenosis - physiopathology</topic><topic>Severity of Illness Index</topic><topic>Stroke Volume - physiology</topic><topic>Tetralogy of Fallot - diagnosis</topic><topic>Tetralogy of Fallot - physiopathology</topic><topic>Tetralogy of Fallot - surgery</topic><topic>Treatment Outcome</topic><topic>Ultrasonography</topic><topic>Veins &amp; arteries</topic><topic>Ventricular Function, Right - physiology</topic><topic>Ventricular Outflow Obstruction - diagnosis</topic><topic>Ventricular Outflow Obstruction - physiopathology</topic><topic>Ventricular Outflow Obstruction - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DAVLOUROS, Periklis A</creatorcontrib><creatorcontrib>KILNER, Philip J</creatorcontrib><creatorcontrib>HORNUNG, Tim S</creatorcontrib><creatorcontrib>WEI LI</creatorcontrib><creatorcontrib>FRANCIS, Jane M</creatorcontrib><creatorcontrib>MOON, James C. C</creatorcontrib><creatorcontrib>SMITH, Gillian C</creatorcontrib><creatorcontrib>TAT, Tri</creatorcontrib><creatorcontrib>PENNELL, Dudley J</creatorcontrib><creatorcontrib>GATZOULIS, Michael A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DAVLOUROS, Periklis A</au><au>KILNER, Philip J</au><au>HORNUNG, Tim S</au><au>WEI LI</au><au>FRANCIS, Jane M</au><au>MOON, James C. C</au><au>SMITH, Gillian C</au><au>TAT, Tri</au><au>PENNELL, Dudley J</au><au>GATZOULIS, Michael A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Right ventricular function in adults with repaired tetralogy of Fallot assessed with cardiovascular magnetic resonance imaging: Detrimental role of right ventricular outflow aneurysms or akinesia and adverse right-to-left ventricular interaction</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>2002-12-04</date><risdate>2002</risdate><volume>40</volume><issue>11</issue><spage>2044</spage><epage>2052</epage><pages>2044-2052</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><coden>JACCDI</coden><abstract><![CDATA[We examined the relationship among biventricular hemodynamics, pulmonary regurgitant fraction (PRF), right ventricular outflow tract (RVOT) aneurysm or akinesia, and baseline and surgical characteristics in adults with repaired tetralogy of Fallot (rTOF). The precise relationship of pulmonary regurgitation with biventricular hemodynamics has been hampered by limitations of right ventricular (RV) imaging. We assessed 85 consecutive adults with rTOF and 26 matched healthy controls using cardiovascular magnetic resonance imaging. Patients had higher right ventricular end-diastolic volume index (RVEDVi) (p < 0.001), right ventricular end-systolic volume index (RVESVi) (p < 0.001), right ventricular mass index (RVMi) (p < 0.001), and lower right ventricular ejection fraction (RVEF) (p < 0.001) and left ventricular ejection fraction (LVEF) (p = 0.002) compared to controls. The PRF (range 0% to 55%) independently predicted RVEDVi (p < 0.01) and the latter predicted RVESVi (p < 0.01) and RVMi (p < 0.01). The RVOT aneurysm/akinesia was present in 48/85 (56.9%) of patients and predicted RV volumes (RVEDVi, p = 0.01, and RVESVi, p = 0.03). There was a negative effect of RVOT aneurysm/akinesia and RVMi on RVEF (p < 0.01 and p = 0.02, respectively). There was only a tendency among patients with transannular or RVOT patching toward RVOT aneurysm/akinesia (p = 0.09). The LVEF correlated with RVEF (r = 0.67, p < 0.001). Pulmonary regurgitation and RVOT aneurysm/akinesia were independently associated with RV dilation and the latter with RV hypertrophy late after rTOF. The RVOT aneurysm/akinesia was common but related only in part to RVOT or transannular patching. Both RV hypertrophy and RVOT aneurysm/akinesia were associated with lower RVEF. Left ventricular systolic dysfunction correlated with RV dysfunction, suggesting an unfavorable ventricular-ventricular interaction. Measures to maintain or restore pulmonary valve function and avoid RVOT aneurysm/akinesia are mandatory for preserving biventricular function late after rTOF.]]></abstract><cop>New York, NY</cop><pub>Elsevier Science</pub><pmid>12475468</pmid><doi>10.1016/S0735-1097(02)02566-4</doi><tpages>9</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0735-1097
ispartof Journal of the American College of Cardiology, 2002-12, Vol.40 (11), p.2044-2052
issn 0735-1097
1558-3597
language eng
recordid cdi_proquest_miscellaneous_72756387
source MEDLINE; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection
subjects Adolescent
Adult
Aged
Biological and medical sciences
Cardiology
Cardiology. Vascular system
Cardiovascular Surgical Procedures
Confidence intervals
Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava
Diagnostic Techniques, Cardiovascular
Dyskinesias - diagnosis
Dyskinesias - physiopathology
Dyskinesias - surgery
Female
Heart
Heart Aneurysm - diagnosis
Heart Aneurysm - physiopathology
Heart Aneurysm - surgery
Heart attacks
Heart Ventricles - diagnostic imaging
Heart Ventricles - physiopathology
Heart Ventricles - surgery
Humans
London
Magnetic Resonance Imaging
Male
Medical sciences
Middle Aged
Mortality
Predictive Value of Tests
Prospective Studies
Pulmonary arteries
Pulmonary Valve Insufficiency - complications
Pulmonary Valve Insufficiency - diagnosis
Pulmonary Valve Insufficiency - surgery
Pulmonary Valve Stenosis - complications
Pulmonary Valve Stenosis - diagnosis
Pulmonary Valve Stenosis - physiopathology
Severity of Illness Index
Stroke Volume - physiology
Tetralogy of Fallot - diagnosis
Tetralogy of Fallot - physiopathology
Tetralogy of Fallot - surgery
Treatment Outcome
Ultrasonography
Veins & arteries
Ventricular Function, Right - physiology
Ventricular Outflow Obstruction - diagnosis
Ventricular Outflow Obstruction - physiopathology
Ventricular Outflow Obstruction - surgery
title Right ventricular function in adults with repaired tetralogy of Fallot assessed with cardiovascular magnetic resonance imaging: Detrimental role of right ventricular outflow aneurysms or akinesia and adverse right-to-left ventricular interaction
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T17%3A56%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Right%20ventricular%20function%20in%20adults%20with%20repaired%20tetralogy%20of%20Fallot%20assessed%20with%20cardiovascular%20magnetic%20resonance%20imaging:%20Detrimental%20role%20of%20right%20ventricular%20outflow%20aneurysms%20or%20akinesia%20and%20adverse%20right-to-left%20ventricular%20interaction&rft.jtitle=Journal%20of%20the%20American%20College%20of%20Cardiology&rft.au=DAVLOUROS,%20Periklis%20A&rft.date=2002-12-04&rft.volume=40&rft.issue=11&rft.spage=2044&rft.epage=2052&rft.pages=2044-2052&rft.issn=0735-1097&rft.eissn=1558-3597&rft.coden=JACCDI&rft_id=info:doi/10.1016/S0735-1097(02)02566-4&rft_dat=%3Cproquest_pubme%3E72756387%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1506129578&rft_id=info:pmid/12475468&rfr_iscdi=true