Cortisol and dehydroepiandosterone sulfate plasma levels and their relationship to aging, cognitive function, and dementia

Cortisol and dehydroepiandosterone sulfate plasma levels and their relationship to aging, cognitive function, and dementia

We have studied the relationship between dehydroepiandrosterone sulfate (DHEAS), cortisol, and cognitive function in a population of demented patients ( n=29), age-matched controls ( n=46), and younger subjects ( n=11). All were submitted to morning collection of blood for determination of plasma co...

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Veröffentlicht in:Brain and cognition 2002-11, Vol.50 (2), p.316-323
Hauptverfasser: de Bruin, V.M.S, Vieira, M.C.M, Rocha, M.N.M, Viana, G.S.B
Format: Artikel
Sprache:eng
Schlagworte:
Adult and adolescent clinical studies
Aged
Aged, 80 and over
Aging - physiology
Alzheimer
Alzheimer Disease - metabolism
Biological and medical sciences
Brain - metabolism
Cognition
Cognition Disorders - metabolism
Cortisol
Cortisol/DHEAS ratio
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dehydroepiandrosterone Sulfate - blood
Dementia
Depression
Depressive Disorder, Major - metabolism
DHEAS
Female
Humans
Hydrocortisone - blood
Male
Medical sciences
Middle Aged
Minimental
Nervous system
Neurology
Organic mental disorders. Neuropsychology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Steroid
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Zusammenfassung:We have studied the relationship between dehydroepiandrosterone sulfate (DHEAS), cortisol, and cognitive function in a population of demented patients ( n=29), age-matched controls ( n=46), and younger subjects ( n=11). All were submitted to morning collection of blood for determination of plasma cortisol and DHEAS measured by 125I radioimmunoassay. DHEAS levels and cortisol/DHEAS ratios were significantly different among groups with higher DHEAS levels and lower cortisol/DHEAS ratios in younger people (Bonferroni p
ISSN:0278-2626
1090-2147
DOI:10.1016/S0278-2626(02)00519-5