Simple and simultaneous determination of sulphapyridine and acetylsulphapyridine in human serum by column-switching high-performance liquid chromatography

Summary Objective: A high‐performance liquid chromatography (HPLC) with an automated on‐line column‐switching system was used for the simultaneous determination of sulphapyridine and acetylsulphapyridine, two major active metabolites related to the adverse effects of sulphasalazine, in human serum....

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Veröffentlicht in:	Journal of clinical pharmacy and therapeutics 2002-12, Vol.27 (6), p.403-408
Hauptverfasser:	Teshima, D., Hino, B., Itoh, Y., Oishi, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylsulphapyridine Administration, Oral adverse effects Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - blood Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Biological and medical sciences Chromatography, High Pressure Liquid - methods column-switching Digestive system Drug Monitoring - methods Humans Medical sciences Pharmacology. Drug treatments Reproducibility of Results Sulfapyridine - analogs & derivatives Sulfapyridine - blood Sulfasalazine - administration & dosage Sulfasalazine - blood Sulfasalazine - pharmacokinetics sulphapyridine
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