In vitro and in vivo characterization of novel nonsteroidal progesterone receptor antagonists derived from the fungal metabolite PF1092C

We studied the pharmacological effects of novel nonsteroidal progesterone receptor antagonists CP8661 and CP8754, which were synthesized from the fungal metabolite PF1092C. CP8661 possess a tetrahydrobenzindolone skeleton and CP8754 possess a tetrahydronaphthofuranone skeleton. In binding assays for...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 2002-10, Vol.82 (2), p.217-223
Hauptverfasser:	Tabata, Yuji, Iizuka, Yumiko, Masuda, Naomi Takei, Shinei, Rie, Kurihara, Ken-ichi, Okonogi, Tsuneo, Hoshiko, Shigeru, Kurata, Yasushi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biological Assay Dose-Response Relationship, Drug Endometrium - metabolism Estrogens - metabolism Female Gene Expression Regulation Genes, Reporter Genital system. Reproduction Hormone Antagonists - chemistry Hormone Antagonists - metabolism Hormone Antagonists - pharmacology Humans McPhail test Medical sciences Molecular Structure Naphthols - chemistry Naphthols - metabolism Naphthols - pharmacology Nonsteroidal progesterone receptor antagonist PF1092 Pharmacology. Drug treatments Progesterone - chemistry Progesterone - metabolism Rabbits Receptors, Androgen - metabolism Receptors, Estrogen - metabolism Receptors, Progesterone - antagonists & inhibitors Receptors, Progesterone - metabolism Sesquiterpenes - chemistry Sesquiterpenes - metabolism Sesquiterpenes - pharmacology T47D Tetrahydrobenzindolone Tetrahydronaphthofuranone Tumor Cells, Cultured
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