Substrate specificity and kinetics of degradation of antisense oligonucleotides by a 3' exonuclease in plasma

The pathways of degradation of oligodeoxynucleotides in plasma from several mammalian species, including human, were investigated. In all cases, hydrolysis occurred exclusively by a 3' to 5' exonucleolytic activity. Human, mouse, and rat plasma degraded oligonucleotides in this fashion at...

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Veröffentlicht in:	Antisense research and development 1991, Vol.1 (2), p.141-151
Hauptverfasser:	Eder, P S, DeVine, R J, Dagle, J M, Walder, J A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Exodeoxyribonuclease V Exodeoxyribonucleases - blood Humans Kinetics Mice Molecular Sequence Data Oligonucleotides, Antisense - metabolism Rabbits Rats Substrate Specificity
Online-Zugang:	Volltext
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