The clinical and histologic criteria that predict metastases from cystosarcoma phyllodes
A retrospective study of 33 patients with cystosarcoma phyllodes was done. Eight of these patients had metastases, and the clinical and histologic criteria predicting the development of metastases were examined. The most reliable predictor was the presence of stromal overgrowth; this appears to be n...
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| Veröffentlicht in: | Cancer 1992-01, Vol.69 (1), p.141-147 |
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| container_title | Cancer |
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| creator | Hawkins, Robert E. Schofield, John B. Fisher, Cyril Wiltshaw, Eve McKinna, J. Alan |
| description | A retrospective study of 33 patients with cystosarcoma phyllodes was done. Eight of these patients had metastases, and the clinical and histologic criteria predicting the development of metastases were examined. The most reliable predictor was the presence of stromal overgrowth; this appears to be necessary for metastasis to occur. Other useful indicators of clinical behavior were the degree of mitotic activity, nuclear pleomorphism, and infiltrating margins. Based on these data and a literature review, the authors suggest close follow‐up of patients whose primary tumors contain areas of stromal overgrowth because, in all series combined, the risk of metastatic spread in such patients was 72% within 5 years. Among these high‐risk patients, local recurrence is another indication that metastasis is likely. |
| doi_str_mv | 10.1002/1097-0142(19920101)69:1<141::AID-CNCR2820690125>3.0.CO;2-1 |
| format | Article |
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Alan</creator><creatorcontrib>Hawkins, Robert E. ; Schofield, John B. ; Fisher, Cyril ; Wiltshaw, Eve ; McKinna, J. Alan</creatorcontrib><description>A retrospective study of 33 patients with cystosarcoma phyllodes was done. Eight of these patients had metastases, and the clinical and histologic criteria predicting the development of metastases were examined. The most reliable predictor was the presence of stromal overgrowth; this appears to be necessary for metastasis to occur. Other useful indicators of clinical behavior were the degree of mitotic activity, nuclear pleomorphism, and infiltrating margins. Based on these data and a literature review, the authors suggest close follow‐up of patients whose primary tumors contain areas of stromal overgrowth because, in all series combined, the risk of metastatic spread in such patients was 72% within 5 years. Among these high‐risk patients, local recurrence is another indication that metastasis is likely.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(19920101)69:1<141::AID-CNCR2820690125>3.0.CO;2-1</identifier><identifier>PMID: 1309302</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Adult ; Aged ; Breast Neoplasms - pathology ; Breast Neoplasms - therapy ; Breast Neoplasms - ultrastructure ; Female ; Follow-Up Studies ; Humans ; Middle Aged ; Neoplasm Recurrence, Local - pathology ; Phyllodes Tumor - pathology ; Phyllodes Tumor - secondary ; Phyllodes Tumor - therapy ; Phyllodes Tumor - ultrastructure ; Predictive Value of Tests ; Retrospective Studies ; Survival Analysis</subject><ispartof>Cancer, 1992-01, Vol.69 (1), p.141-147</ispartof><rights>Copyright © 1992 American Cancer Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3835-41abb3b55da30288562322f74eb871e294923f9225084affadf30c416521a0473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1309302$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hawkins, Robert E.</creatorcontrib><creatorcontrib>Schofield, John B.</creatorcontrib><creatorcontrib>Fisher, Cyril</creatorcontrib><creatorcontrib>Wiltshaw, Eve</creatorcontrib><creatorcontrib>McKinna, J. Alan</creatorcontrib><title>The clinical and histologic criteria that predict metastases from cystosarcoma phyllodes</title><title>Cancer</title><addtitle>Cancer</addtitle><description>A retrospective study of 33 patients with cystosarcoma phyllodes was done. Eight of these patients had metastases, and the clinical and histologic criteria predicting the development of metastases were examined. The most reliable predictor was the presence of stromal overgrowth; this appears to be necessary for metastasis to occur. Other useful indicators of clinical behavior were the degree of mitotic activity, nuclear pleomorphism, and infiltrating margins. Based on these data and a literature review, the authors suggest close follow‐up of patients whose primary tumors contain areas of stromal overgrowth because, in all series combined, the risk of metastatic spread in such patients was 72% within 5 years. Among these high‐risk patients, local recurrence is another indication that metastasis is likely.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - therapy</subject><subject>Breast Neoplasms - ultrastructure</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Phyllodes Tumor - pathology</subject><subject>Phyllodes Tumor - secondary</subject><subject>Phyllodes Tumor - therapy</subject><subject>Phyllodes Tumor - ultrastructure</subject><subject>Predictive Value of Tests</subject><subject>Retrospective Studies</subject><subject>Survival Analysis</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkG9rFDEQxoNY6rX6EYS8En2x50z-7G7OItS11kLxQCoU34RsNutFsrdnske5b2-OaxV9IQgDw_A888zwI-QdwhwB2GsEVRWAgr1EpRgg4KtSLfAMBS4W51fvi-ZT85nVDEoFyORbPod5s3zDCnxEZr-WH5MZANSFFPz2CTlJ6XseKyb5MTlGDooDm5Hbm5WjNvi1tyZQs-7oyqdpDOM3b6mNfnLRGzqtzEQ30XXeTnRwk0m5XKJ9HAdqd3khmWjHwdDNahfC2Ln0lBz1JiT37L6fki8fLm6aj8X18vKqOb8uLK-5LASatuWtlJ3J_9S1LBlnrK-Ea-sKHVNCMd4rxiTUwvS96XoOVmApGRoQFT8lLw65mzj-2Lo06cEn60Iwazduk65YJTkKno1fD0Ybx5Si6_Um-sHEnUbQe-x6T07vyekH7LpUGnXGrnXGrv_ErrkG3Sx1tufw5_dfbNvBdb-jD5yz7g76nQ9u91-X_3n4L4X_BGURnwY</recordid><startdate>19920101</startdate><enddate>19920101</enddate><creator>Hawkins, Robert E.</creator><creator>Schofield, John B.</creator><creator>Fisher, Cyril</creator><creator>Wiltshaw, Eve</creator><creator>McKinna, J. Alan</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920101</creationdate><title>The clinical and histologic criteria that predict metastases from cystosarcoma phyllodes</title><author>Hawkins, Robert E. ; Schofield, John B. ; Fisher, Cyril ; Wiltshaw, Eve ; McKinna, J. Alan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3835-41abb3b55da30288562322f74eb871e294923f9225084affadf30c416521a0473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - therapy</topic><topic>Breast Neoplasms - ultrastructure</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Phyllodes Tumor - pathology</topic><topic>Phyllodes Tumor - secondary</topic><topic>Phyllodes Tumor - therapy</topic><topic>Phyllodes Tumor - ultrastructure</topic><topic>Predictive Value of Tests</topic><topic>Retrospective Studies</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hawkins, Robert E.</creatorcontrib><creatorcontrib>Schofield, John B.</creatorcontrib><creatorcontrib>Fisher, Cyril</creatorcontrib><creatorcontrib>Wiltshaw, Eve</creatorcontrib><creatorcontrib>McKinna, J. Alan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hawkins, Robert E.</au><au>Schofield, John B.</au><au>Fisher, Cyril</au><au>Wiltshaw, Eve</au><au>McKinna, J. Alan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The clinical and histologic criteria that predict metastases from cystosarcoma phyllodes</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1992-01-01</date><risdate>1992</risdate><volume>69</volume><issue>1</issue><spage>141</spage><epage>147</epage><pages>141-147</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><abstract>A retrospective study of 33 patients with cystosarcoma phyllodes was done. Eight of these patients had metastases, and the clinical and histologic criteria predicting the development of metastases were examined. The most reliable predictor was the presence of stromal overgrowth; this appears to be necessary for metastasis to occur. Other useful indicators of clinical behavior were the degree of mitotic activity, nuclear pleomorphism, and infiltrating margins. Based on these data and a literature review, the authors suggest close follow‐up of patients whose primary tumors contain areas of stromal overgrowth because, in all series combined, the risk of metastatic spread in such patients was 72% within 5 years. Among these high‐risk patients, local recurrence is another indication that metastasis is likely.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>1309302</pmid><doi>10.1002/1097-0142(19920101)69:1<141::AID-CNCR2820690125>3.0.CO;2-1</doi><tpages>7</tpages></addata></record> |
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| ispartof | Cancer, 1992-01, Vol.69 (1), p.141-147 |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Breast Neoplasms - pathology Breast Neoplasms - therapy Breast Neoplasms - ultrastructure Female Follow-Up Studies Humans Middle Aged Neoplasm Recurrence, Local - pathology Phyllodes Tumor - pathology Phyllodes Tumor - secondary Phyllodes Tumor - therapy Phyllodes Tumor - ultrastructure Predictive Value of Tests Retrospective Studies Survival Analysis |
| title | The clinical and histologic criteria that predict metastases from cystosarcoma phyllodes |
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