Objective assessment of spasticity, strength, and function with early exhibition of dantrolene sodium after cerebrovascular accident : a randomized double-blind study
A double-blind, placebo-controlled trial was conducted to determine whether early exhibition of Dantrium (Dantrolene Sodium) in patients with cerebrovascular accidents, before the onset of significant spasticity, would enhance the functional outcome of rehabilitation. Thirty-eight patients were enro...
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| Veröffentlicht in: | Archives of physical medicine and rehabilitation 1992, Vol.73 (1), p.4-9 |
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| container_title | Archives of physical medicine and rehabilitation |
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| creator | KATRAK, P. H COLE, A. M. D POULOS, C. J MCCAULEY, J. C. K |
| description | A double-blind, placebo-controlled trial was conducted to determine whether early exhibition of Dantrium (Dantrolene Sodium) in patients with cerebrovascular accidents, before the onset of significant spasticity, would enhance the functional outcome of rehabilitation. Thirty-eight patients were enrolled in the trial and 31 satisfactorily completed the study. A modified Cybex isokinetic dynamometer was used to gather information on strength and muscle tone. Clinical, functional, and biochemical data were also collected. It was found that Dantrium reduced strength in the unaffected limbs but did not alter strength in the paretic limbs. Dantrium produced no alteration in clinical tone, functional outcome, or biochemical tests at the dosage (200 mg per day) used in this study. |
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H ; COLE, A. M. D ; POULOS, C. J ; MCCAULEY, J. C. K</creator><creatorcontrib>KATRAK, P. H ; COLE, A. M. D ; POULOS, C. J ; MCCAULEY, J. C. K</creatorcontrib><description>A double-blind, placebo-controlled trial was conducted to determine whether early exhibition of Dantrium (Dantrolene Sodium) in patients with cerebrovascular accidents, before the onset of significant spasticity, would enhance the functional outcome of rehabilitation. Thirty-eight patients were enrolled in the trial and 31 satisfactorily completed the study. A modified Cybex isokinetic dynamometer was used to gather information on strength and muscle tone. Clinical, functional, and biochemical data were also collected. It was found that Dantrium reduced strength in the unaffected limbs but did not alter strength in the paretic limbs. Dantrium produced no alteration in clinical tone, functional outcome, or biochemical tests at the dosage (200 mg per day) used in this study.</description><identifier>ISSN: 0003-9993</identifier><identifier>EISSN: 1532-821X</identifier><identifier>PMID: 1729971</identifier><identifier>CODEN: APMHAI</identifier><language>eng</language><publisher>New York, NY: Elsevier</publisher><subject>Aged ; Aged, 80 and over ; Biological and medical sciences ; Cerebrovascular Disorders - drug therapy ; Cerebrovascular Disorders - physiopathology ; Dantrolene - therapeutic use ; Double-Blind Method ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Movement - drug effects ; Muscle ; Muscle Spasticity - drug therapy ; Pharmacology. Drug treatments</subject><ispartof>Archives of physical medicine and rehabilitation, 1992, Vol.73 (1), p.4-9</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5518306$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1729971$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KATRAK, P. H</creatorcontrib><creatorcontrib>COLE, A. M. D</creatorcontrib><creatorcontrib>POULOS, C. J</creatorcontrib><creatorcontrib>MCCAULEY, J. C. K</creatorcontrib><title>Objective assessment of spasticity, strength, and function with early exhibition of dantrolene sodium after cerebrovascular accident : a randomized double-blind study</title><title>Archives of physical medicine and rehabilitation</title><addtitle>Arch Phys Med Rehabil</addtitle><description>A double-blind, placebo-controlled trial was conducted to determine whether early exhibition of Dantrium (Dantrolene Sodium) in patients with cerebrovascular accidents, before the onset of significant spasticity, would enhance the functional outcome of rehabilitation. Thirty-eight patients were enrolled in the trial and 31 satisfactorily completed the study. A modified Cybex isokinetic dynamometer was used to gather information on strength and muscle tone. Clinical, functional, and biochemical data were also collected. It was found that Dantrium reduced strength in the unaffected limbs but did not alter strength in the paretic limbs. Dantrium produced no alteration in clinical tone, functional outcome, or biochemical tests at the dosage (200 mg per day) used in this study.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Cerebrovascular Disorders - drug therapy</subject><subject>Cerebrovascular Disorders - physiopathology</subject><subject>Dantrolene - therapeutic use</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Movement - drug effects</subject><subject>Muscle</subject><subject>Muscle Spasticity - drug therapy</subject><subject>Pharmacology. Drug treatments</subject><issn>0003-9993</issn><issn>1532-821X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUctuFDEQHCGisAQ-AckHxCkj-TFej7mhiJcUKRci5bZq2z2sI894cXsCmw_iOzGw4sqp1V1VXa3qJ91GaCX7UYq7p92Gc656a6161j0num_tVitx3p0LI601YtP9vHH36Gt8QAZESDTjUlmeGB2AavSxHi8Z1YLL17q_ZLAENq1LE-SFfY91zxBKOjL8sY8u_pk2bYCllpxwQUY5xHVmMFUszGNBV_IDkF8TFAbex_Db7y0DVtruPMdHDCzk1SXsXYrNjuoaji-6swkS4ctTvehuP7z_cvWpv775-Pnq3XV_kNtt7dGMCgF5sMMwKKWlVZpPMJopOBTBcDmgkc6ISQYtRgwDeCMHjn70ZuROXXRv_u49lPxtRaq7OZLHlGDBvNLOSKO5tuq_RDGaQVitG_HVibi6GcPuUOIM5bg7faDhr094SwXS1GLwkf7RdDtT8a36BcQclBs</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>KATRAK, P. H</creator><creator>COLE, A. M. D</creator><creator>POULOS, C. J</creator><creator>MCCAULEY, J. C. 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K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p266t-e783eae0d944433529350fa87fdbe1d7024e72b71f2d518ed4ac7240ec8c780b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Cerebrovascular Disorders - drug therapy</topic><topic>Cerebrovascular Disorders - physiopathology</topic><topic>Dantrolene - therapeutic use</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Movement - drug effects</topic><topic>Muscle</topic><topic>Muscle Spasticity - drug therapy</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KATRAK, P. H</creatorcontrib><creatorcontrib>COLE, A. M. D</creatorcontrib><creatorcontrib>POULOS, C. J</creatorcontrib><creatorcontrib>MCCAULEY, J. C. K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Physical Education Index</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of physical medicine and rehabilitation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KATRAK, P. H</au><au>COLE, A. M. D</au><au>POULOS, C. J</au><au>MCCAULEY, J. C. K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Objective assessment of spasticity, strength, and function with early exhibition of dantrolene sodium after cerebrovascular accident : a randomized double-blind study</atitle><jtitle>Archives of physical medicine and rehabilitation</jtitle><addtitle>Arch Phys Med Rehabil</addtitle><date>1992</date><risdate>1992</risdate><volume>73</volume><issue>1</issue><spage>4</spage><epage>9</epage><pages>4-9</pages><issn>0003-9993</issn><eissn>1532-821X</eissn><coden>APMHAI</coden><abstract>A double-blind, placebo-controlled trial was conducted to determine whether early exhibition of Dantrium (Dantrolene Sodium) in patients with cerebrovascular accidents, before the onset of significant spasticity, would enhance the functional outcome of rehabilitation. Thirty-eight patients were enrolled in the trial and 31 satisfactorily completed the study. A modified Cybex isokinetic dynamometer was used to gather information on strength and muscle tone. Clinical, functional, and biochemical data were also collected. It was found that Dantrium reduced strength in the unaffected limbs but did not alter strength in the paretic limbs. Dantrium produced no alteration in clinical tone, functional outcome, or biochemical tests at the dosage (200 mg per day) used in this study.</abstract><cop>New York, NY</cop><pub>Elsevier</pub><pmid>1729971</pmid><tpages>6</tpages></addata></record> |
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| ispartof | Archives of physical medicine and rehabilitation, 1992, Vol.73 (1), p.4-9 |
| issn | 0003-9993 1532-821X |
| language | eng |
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| source | Electronic Journals Library; MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aged Aged, 80 and over Biological and medical sciences Cerebrovascular Disorders - drug therapy Cerebrovascular Disorders - physiopathology Dantrolene - therapeutic use Double-Blind Method Female Humans Male Medical sciences Middle Aged Movement - drug effects Muscle Muscle Spasticity - drug therapy Pharmacology. Drug treatments |
| title | Objective assessment of spasticity, strength, and function with early exhibition of dantrolene sodium after cerebrovascular accident : a randomized double-blind study |
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