Randomized, double-blind, placebo controlled, multicentre study of idebenone in patients suffering from multi-infarct dementia

Randomized, double-blind, placebo controlled, multicentre study of idebenone in patients suffering from multi-infarct dementia

In this randomized double-blind, placebo controlled, multicentre study on 108 elderly patients with mild to moderate mental deterioration of vascular origin, idebenone — a benzoquinone derivative with a hydroxyalkyl side chain — proved to be therapeutically effective in the treatment of multi-infarc...

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Veröffentlicht in:Archives of gerontology and geriatrics 1992-11, Vol.15 (3), p.239-248
Hauptverfasser: Marigliano, Vicenzo, Abate, Giuseppe, Barbagallo-Sangiorgi, Giuseppe, Bartorelli, Luisa, Capurso, Antonio, Cucinotta, Domenico, Cuzzupoli, Marco, Senin, Umberto, Tammaro, Aldo E., Fioravanti, Mario
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Clinical trial
Idebenone, Multi-infarct dementria
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container_end_page 248
container_issue 3
container_start_page 239
container_title Archives of gerontology and geriatrics
container_volume 15
creator Marigliano, Vicenzo
Abate, Giuseppe
Barbagallo-Sangiorgi, Giuseppe
Bartorelli, Luisa
Capurso, Antonio
Cucinotta, Domenico
Cuzzupoli, Marco
Senin, Umberto
Tammaro, Aldo E.
Fioravanti, Mario
description In this randomized double-blind, placebo controlled, multicentre study on 108 elderly patients with mild to moderate mental deterioration of vascular origin, idebenone — a benzoquinone derivative with a hydroxyalkyl side chain — proved to be therapeutically effective in the treatment of multi-infarct dementia. The oral administration of idebenone 45 mg/day b.i.d. for 120 days significantly improved the scores of the following test in comparison with placebo: Mini Mental State, Randt Memory Test, Gottfries Rating Scale, Token Test, Toulouse Piéron Test, indicating improvements in memory attention and cognitivity. The drug was well tolerated and effective in patients with multi-infarct dementria. No changes in laboratory parameters were observed either before or after treatment.
doi_str_mv 10.1016/0167-4943(92)90059-D
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1872-6976
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subjects Clinical trial
Idebenone, Multi-infarct dementria
title Randomized, double-blind, placebo controlled, multicentre study of idebenone in patients suffering from multi-infarct dementia
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