Presynaptic Glutamate Receptors Regulate Noradrenaline Release from Isolated Nerve Terminals
: The wide‐ranging neuronal actions of excitatory amino acids, such as glutamate, are thought to be mediated mainly by postsynaptic N‐methyl‐D‐aspartate (NMDA) and non‐NMDA receptors. We now report the existence of presynaptic glutamate receptors in isolated nerve terminals (synaptosomes) prepared f...
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| Veröffentlicht in: | Journal of neurochemistry 1992-01, Vol.58 (1), p.204-211 |
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| creator | Wang, James K. T. Andrews, Helene Thukral, Vijay |
| description | : The wide‐ranging neuronal actions of excitatory amino acids, such as glutamate, are thought to be mediated mainly by postsynaptic N‐methyl‐D‐aspartate (NMDA) and non‐NMDA receptors. We now report the existence of presynaptic glutamate receptors in isolated nerve terminals (synaptosomes) prepared from hippocampus, olfactory bulb, and cerebral cortex. Activation of these receptors by NMDA or non‐NMDA agonists, in a concentration‐dependent manner, resulted in Ca2+‐dependent release of noradrenaline from vesicular transmitter stores. The NMDA‐stimulated release was potentiated by glycine and was blocked by Mg2+ and selective NMDA antagonists. In contrast, release stimulated by selective non‐NMDA agonists was blocked by 6‐cyano‐7‐nitroquinoxaline‐2,3‐dione, but not by Mg2+ or NMDA antagonists. Our data suggest that the presynaptic glutamate receptors can be classified pharmacologically as both the NMDA and non‐NMDA types. These receptors, localized on nerve terminals of the locus ceruleus noradrenergic neurons, may play an important role in interactions between noradrenaline and glutamate. |
| doi_str_mv | 10.1111/j.1471-4159.1992.tb09297.x |
| format | Article |
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T. ; Andrews, Helene ; Thukral, Vijay</creator><creatorcontrib>Wang, James K. T. ; Andrews, Helene ; Thukral, Vijay</creatorcontrib><description>: The wide‐ranging neuronal actions of excitatory amino acids, such as glutamate, are thought to be mediated mainly by postsynaptic N‐methyl‐D‐aspartate (NMDA) and non‐NMDA receptors. We now report the existence of presynaptic glutamate receptors in isolated nerve terminals (synaptosomes) prepared from hippocampus, olfactory bulb, and cerebral cortex. Activation of these receptors by NMDA or non‐NMDA agonists, in a concentration‐dependent manner, resulted in Ca2+‐dependent release of noradrenaline from vesicular transmitter stores. The NMDA‐stimulated release was potentiated by glycine and was blocked by Mg2+ and selective NMDA antagonists. In contrast, release stimulated by selective non‐NMDA agonists was blocked by 6‐cyano‐7‐nitroquinoxaline‐2,3‐dione, but not by Mg2+ or NMDA antagonists. Our data suggest that the presynaptic glutamate receptors can be classified pharmacologically as both the NMDA and non‐NMDA types. These receptors, localized on nerve terminals of the locus ceruleus noradrenergic neurons, may play an important role in interactions between noradrenaline and glutamate.</description><identifier>ISSN: 0022-3042</identifier><identifier>EISSN: 1471-4159</identifier><identifier>DOI: 10.1111/j.1471-4159.1992.tb09297.x</identifier><identifier>PMID: 1345765</identifier><identifier>CODEN: JONRA9</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Biological and medical sciences ; Calcium - physiology ; Central nervous system ; Central neurotransmission. Neuromudulation. Pathways and receptors ; Desipramine - pharmacology ; Dopamine - metabolism ; Excitatory amino acids ; Fundamental and applied biological sciences. Psychology ; Glutamates - pharmacology ; Glutamates - physiology ; Glutamic Acid ; In Vitro Techniques ; Male ; N-methyl-D-aspartic acid ; N-Methylaspartate - pharmacology ; nerve endings ; Nerve Endings - metabolism ; Neurotransmitter release ; norepinephrine ; Norepinephrine - metabolism ; presynapse ; Presynaptic non‐N‐methyl‐D‐aspartate receptors ; Presynaptic N‐methyl‐D‐aspartate receptors ; Rats ; Rats, Inbred Strains ; Receptors, Glutamate ; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors ; Receptors, N-Methyl-D-Aspartate - physiology ; Receptors, Neurotransmitter - physiology ; Reserpine - pharmacology ; Synapses - metabolism ; Synaptosomes ; Vertebrates: nervous system and sense organs</subject><ispartof>Journal of neurochemistry, 1992-01, Vol.58 (1), p.204-211</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4954-6f00445e52dfd7199f6f1841ef8c495ca7dc3fda6c8f1d933895238e721109da3</citedby><cites>FETCH-LOGICAL-c4954-6f00445e52dfd7199f6f1841ef8c495ca7dc3fda6c8f1d933895238e721109da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1471-4159.1992.tb09297.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1471-4159.1992.tb09297.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,4024,27923,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4414832$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1345765$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, James K. T.</creatorcontrib><creatorcontrib>Andrews, Helene</creatorcontrib><creatorcontrib>Thukral, Vijay</creatorcontrib><title>Presynaptic Glutamate Receptors Regulate Noradrenaline Release from Isolated Nerve Terminals</title><title>Journal of neurochemistry</title><addtitle>J Neurochem</addtitle><description>: The wide‐ranging neuronal actions of excitatory amino acids, such as glutamate, are thought to be mediated mainly by postsynaptic N‐methyl‐D‐aspartate (NMDA) and non‐NMDA receptors. We now report the existence of presynaptic glutamate receptors in isolated nerve terminals (synaptosomes) prepared from hippocampus, olfactory bulb, and cerebral cortex. Activation of these receptors by NMDA or non‐NMDA agonists, in a concentration‐dependent manner, resulted in Ca2+‐dependent release of noradrenaline from vesicular transmitter stores. The NMDA‐stimulated release was potentiated by glycine and was blocked by Mg2+ and selective NMDA antagonists. In contrast, release stimulated by selective non‐NMDA agonists was blocked by 6‐cyano‐7‐nitroquinoxaline‐2,3‐dione, but not by Mg2+ or NMDA antagonists. Our data suggest that the presynaptic glutamate receptors can be classified pharmacologically as both the NMDA and non‐NMDA types. These receptors, localized on nerve terminals of the locus ceruleus noradrenergic neurons, may play an important role in interactions between noradrenaline and glutamate.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Calcium - physiology</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>Desipramine - pharmacology</subject><subject>Dopamine - metabolism</subject><subject>Excitatory amino acids</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glutamates - pharmacology</subject><subject>Glutamates - physiology</subject><subject>Glutamic Acid</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>N-methyl-D-aspartic acid</subject><subject>N-Methylaspartate - pharmacology</subject><subject>nerve endings</subject><subject>Nerve Endings - metabolism</subject><subject>Neurotransmitter release</subject><subject>norepinephrine</subject><subject>Norepinephrine - metabolism</subject><subject>presynapse</subject><subject>Presynaptic non‐N‐methyl‐D‐aspartate receptors</subject><subject>Presynaptic N‐methyl‐D‐aspartate receptors</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Receptors, Glutamate</subject><subject>Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors</subject><subject>Receptors, N-Methyl-D-Aspartate - physiology</subject><subject>Receptors, Neurotransmitter - physiology</subject><subject>Reserpine - pharmacology</subject><subject>Synapses - metabolism</subject><subject>Synaptosomes</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0022-3042</issn><issn>1471-4159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkV1rFDEUhoNY6rb6E4RBxLsZc_IxmXghyGJrpWyL1DshpMmJzDIfazKj3X9vhl3qpTQ3J-R9zknyvoS8AVpBXu-3FQgFpQCpK9CaVdM91Uyr6uEZWT1Kz8mKUsZKTgV7Qc5S2lIKtajhlJwCF1LVckV-3EZM-8HuptYVl9082d5OWHxDh7tpjCnvfs7dcrQZo_URB9u1wwJ0aBMWIY59cZXGBfHFBuNvLO4w9m3m0ktyEnLBV8d6Tr5ffL5bfymvby6v1p-uSye0FGUdKBVComQ-eJU_FOoAjQAMzQI4q7zjwdvaNQG85rzRkvEGFQOg2lt-Tt4d5u7i-GvGNJm-TQ67zg44zskopoRQEv4LQk2VlrTJ4IcD6OKYUsRgdrHtbdwboGbJwGzNYrRZjDZLBuaYgXnIza-Pt8z3Pfp_rQfTs_72qNvkbBeiHVybHjEhQDScZezjAfvTdrh_wgPM182aUcH_AmPIpAU</recordid><startdate>199201</startdate><enddate>199201</enddate><creator>Wang, James K. T.</creator><creator>Andrews, Helene</creator><creator>Thukral, Vijay</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>199201</creationdate><title>Presynaptic Glutamate Receptors Regulate Noradrenaline Release from Isolated Nerve Terminals</title><author>Wang, James K. T. ; Andrews, Helene ; Thukral, Vijay</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4954-6f00445e52dfd7199f6f1841ef8c495ca7dc3fda6c8f1d933895238e721109da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Calcium - physiology</topic><topic>Central nervous system</topic><topic>Central neurotransmission. Neuromudulation. Pathways and receptors</topic><topic>Desipramine - pharmacology</topic><topic>Dopamine - metabolism</topic><topic>Excitatory amino acids</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glutamates - pharmacology</topic><topic>Glutamates - physiology</topic><topic>Glutamic Acid</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>N-methyl-D-aspartic acid</topic><topic>N-Methylaspartate - pharmacology</topic><topic>nerve endings</topic><topic>Nerve Endings - metabolism</topic><topic>Neurotransmitter release</topic><topic>norepinephrine</topic><topic>Norepinephrine - metabolism</topic><topic>presynapse</topic><topic>Presynaptic non‐N‐methyl‐D‐aspartate receptors</topic><topic>Presynaptic N‐methyl‐D‐aspartate receptors</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Receptors, Glutamate</topic><topic>Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors</topic><topic>Receptors, N-Methyl-D-Aspartate - physiology</topic><topic>Receptors, Neurotransmitter - physiology</topic><topic>Reserpine - pharmacology</topic><topic>Synapses - metabolism</topic><topic>Synaptosomes</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, James K. T.</creatorcontrib><creatorcontrib>Andrews, Helene</creatorcontrib><creatorcontrib>Thukral, Vijay</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, James K. T.</au><au>Andrews, Helene</au><au>Thukral, Vijay</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Presynaptic Glutamate Receptors Regulate Noradrenaline Release from Isolated Nerve Terminals</atitle><jtitle>Journal of neurochemistry</jtitle><addtitle>J Neurochem</addtitle><date>1992-01</date><risdate>1992</risdate><volume>58</volume><issue>1</issue><spage>204</spage><epage>211</epage><pages>204-211</pages><issn>0022-3042</issn><eissn>1471-4159</eissn><coden>JONRA9</coden><abstract>: The wide‐ranging neuronal actions of excitatory amino acids, such as glutamate, are thought to be mediated mainly by postsynaptic N‐methyl‐D‐aspartate (NMDA) and non‐NMDA receptors. We now report the existence of presynaptic glutamate receptors in isolated nerve terminals (synaptosomes) prepared from hippocampus, olfactory bulb, and cerebral cortex. Activation of these receptors by NMDA or non‐NMDA agonists, in a concentration‐dependent manner, resulted in Ca2+‐dependent release of noradrenaline from vesicular transmitter stores. The NMDA‐stimulated release was potentiated by glycine and was blocked by Mg2+ and selective NMDA antagonists. In contrast, release stimulated by selective non‐NMDA agonists was blocked by 6‐cyano‐7‐nitroquinoxaline‐2,3‐dione, but not by Mg2+ or NMDA antagonists. Our data suggest that the presynaptic glutamate receptors can be classified pharmacologically as both the NMDA and non‐NMDA types. These receptors, localized on nerve terminals of the locus ceruleus noradrenergic neurons, may play an important role in interactions between noradrenaline and glutamate.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>1345765</pmid><doi>10.1111/j.1471-4159.1992.tb09297.x</doi><tpages>8</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Calcium - physiology Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Desipramine - pharmacology Dopamine - metabolism Excitatory amino acids Fundamental and applied biological sciences. Psychology Glutamates - pharmacology Glutamates - physiology Glutamic Acid In Vitro Techniques Male N-methyl-D-aspartic acid N-Methylaspartate - pharmacology nerve endings Nerve Endings - metabolism Neurotransmitter release norepinephrine Norepinephrine - metabolism presynapse Presynaptic non‐N‐methyl‐D‐aspartate receptors Presynaptic N‐methyl‐D‐aspartate receptors Rats Rats, Inbred Strains Receptors, Glutamate Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - physiology Receptors, Neurotransmitter - physiology Reserpine - pharmacology Synapses - metabolism Synaptosomes Vertebrates: nervous system and sense organs |
| title | Presynaptic Glutamate Receptors Regulate Noradrenaline Release from Isolated Nerve Terminals |
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