Degradation of Quillaja saponaria Molina saponins: loss of the protective effects of a herpes simplex virus 1 subunit vaccine

Quillaja saponins (Q. saponins) are readily hydrolyzed at neutral pH to yield degraded deacylated saponins (DS-saponins). Degradation of Q. saponins resulted in some reduction of their capacity to elicit IgG1, IgG2a and IgG2b isotypes against the highly immunogenic envelope glycoprotein D (gD) from...

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Veröffentlicht in:	International immunopharmacology 2002-11, Vol.2 (12), p.1703-1711
Hauptverfasser:	Marciani, Dante J, Ptak, Roger G, Voss, Thomas G, Reynolds, Robert C, Pathak, Ashish K, Chamblin, Tyler L, Scholl, David R, May, Richard D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants Animals Antibodies, Viral - analysis Biological and medical sciences Female Herpes Simplex - immunology Herpes Simplex - prevention & control Herpes Simplex - virology Herpes Simplex Virus Vaccines - chemistry Herpes Simplex Virus Vaccines - immunology Herpes Simplex Virus Vaccines - metabolism Herpesvirus 1, Human - genetics Herpesvirus 1, Human - immunology Herpesvirus 1, Human - isolation & purification Herpesvirus 1, Human - physiology HSV-1 Immunoglobulin G - analysis Immunomodulators Medical sciences Mice Mice, Inbred BALB C Neutralization Tests Pharmacology. Drug treatments Quillaja - chemistry Saponins Saponins - metabolism Survival Rate Trigeminal Ganglion - virology Vaccines Vaccines, Subunit - chemistry Vaccines, Subunit - immunology Vaccines, Subunit - metabolism
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