p53 codon 72 polymorphism (C/G) and the risk of human papillomavirus‐associated carcinomas in China
BACKGROUND Human papillomavirus (HPV) plays an important role in the development of carcinomas at various body sites. It was found previously that the p53 codon 72 polymorphism (C/G) is a high‐risk factor for the development HPV‐associated cervical carcinoma. However, it still was considered controv...
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| Veröffentlicht in: | Cancer 2002-12, Vol.95 (12), p.2571-2576 |
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| container_title | Cancer |
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| creator | Li, Tao Lu, Zhe‐Ming Guo, Mei Wu, Qin‐Jiao Chen, Ke‐Neng Xing, Hai‐Ping Mei, Qiang Ke, Yang |
| description | BACKGROUND
Human papillomavirus (HPV) plays an important role in the development of carcinomas at various body sites. It was found previously that the p53 codon 72 polymorphism (C/G) is a high‐risk factor for the development HPV‐associated cervical carcinoma. However, it still was considered controversial in several studies of cervical and esophageal carcinoma.
METHODS
In the current study, the authors used an allele specific polymerase chain reaction (PCR) method to analyze correlation between the p53 codon 72 (C/G) polymorphism and HPV‐associated, noncancerous esophageal epithelium as well as esophageal, ovarian, and breast carcinoma in the Chinese population. Esophageal balloon cytology examination samples were obtained from high‐incidence and low‐incidence populations for esophageal carcinoma in Anyang (Henan Province).
RESULTS
Thirty‐six of 48 esophageal balloon samples from the high‐incidence population were HPV positive, and 13 of 33 esophageal balloon samples from the low‐incidence population were HPV positive. Thirty‐nine of 62 esophageal carcinoma samples from Anyang Tumor Hospital were HPV positive. Twenty‐six of 39 ovarian carcinoma samples from the Second Affiliated Hospital of Inner Mongolia Medical College were HPV positive. Nineteen of 82 breast carcinoma samples from Beijing Cancer Hospital were HPV positive. It is noteworthy that the distribution of the p53 codon 72 Arg homozygous genotype in HPV positive samples of esophageal epithelium, ovarian carcinoma, and breast carcinoma was significantly higher compared with HPV negative tumor samples. (P < 0.05).
CONCLUSIONS
The current results suggest that the p53 codon 72 Arg homozygous genotype is one of the high‐risk genetic factors for HPV‐associated malignancies among the Chinese population. Cancer 2002;95:2571–6. © 2002 American Cancer Society.
DOI 10.1002/cncr.11008
The current study showed that the p53 codon 72 Arg homozygous genotype is one of the high‐risk genetic factors for human papillomavirus‐associated malignancies among the Chinese population. |
| doi_str_mv | 10.1002/cncr.11008 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72742234</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72742234</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3558-5a63f9476a6a53d200b833d173bccea74835165e88ff5e7e21074220209e970a3</originalsourceid><addsrcrecordid>eNp90M1KAzEQB_AgitbqxQeQXBQVqvncbI-y-AWiIArelmk2S6O7yZp0ld58BJ_RJzG1BW-ekkl-zAx_hPYoOaWEsDPtdDil6ZqvoQElYzUiVLB1NCDpaSQFf95C2zG-pFIxyTfRFmUiU6kYINNJjrWvvMOK4c4389aHbmpji4-Ks6tjDK7Cs6nBwcZX7Gs87VtwuIPONo1v4d2GPn5_fkGMXluYmQprCNq69BexdbiYWgc7aKOGJprd1TlET5cXj8X16Pb-6qY4vx1pLmVaFTJej4XKIAPJK0bIJOe8oopPtDagRM4lzaTJ87qWRhlGiRKMEUbGZqwI8CE6XPbtgn_rTZyVrY3aNA044_tYKrbwXCR4soQ6-BiDqcsu2BbCvKSkXIRaLkItf0NNeH_VtZ-0pvqjqxQTOFgBiBqaOoDTNv45IZjiiiRHl-7DNmb-z8iyuCselsN_AJtbjeM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72742234</pqid></control><display><type>article</type><title>p53 codon 72 polymorphism (C/G) and the risk of human papillomavirus‐associated carcinomas in China</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Wiley Online Library Free Content</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Li, Tao ; Lu, Zhe‐Ming ; Guo, Mei ; Wu, Qin‐Jiao ; Chen, Ke‐Neng ; Xing, Hai‐Ping ; Mei, Qiang ; Ke, Yang</creator><creatorcontrib>Li, Tao ; Lu, Zhe‐Ming ; Guo, Mei ; Wu, Qin‐Jiao ; Chen, Ke‐Neng ; Xing, Hai‐Ping ; Mei, Qiang ; Ke, Yang</creatorcontrib><description>BACKGROUND
Human papillomavirus (HPV) plays an important role in the development of carcinomas at various body sites. It was found previously that the p53 codon 72 polymorphism (C/G) is a high‐risk factor for the development HPV‐associated cervical carcinoma. However, it still was considered controversial in several studies of cervical and esophageal carcinoma.
METHODS
In the current study, the authors used an allele specific polymerase chain reaction (PCR) method to analyze correlation between the p53 codon 72 (C/G) polymorphism and HPV‐associated, noncancerous esophageal epithelium as well as esophageal, ovarian, and breast carcinoma in the Chinese population. Esophageal balloon cytology examination samples were obtained from high‐incidence and low‐incidence populations for esophageal carcinoma in Anyang (Henan Province).
RESULTS
Thirty‐six of 48 esophageal balloon samples from the high‐incidence population were HPV positive, and 13 of 33 esophageal balloon samples from the low‐incidence population were HPV positive. Thirty‐nine of 62 esophageal carcinoma samples from Anyang Tumor Hospital were HPV positive. Twenty‐six of 39 ovarian carcinoma samples from the Second Affiliated Hospital of Inner Mongolia Medical College were HPV positive. Nineteen of 82 breast carcinoma samples from Beijing Cancer Hospital were HPV positive. It is noteworthy that the distribution of the p53 codon 72 Arg homozygous genotype in HPV positive samples of esophageal epithelium, ovarian carcinoma, and breast carcinoma was significantly higher compared with HPV negative tumor samples. (P < 0.05).
CONCLUSIONS
The current results suggest that the p53 codon 72 Arg homozygous genotype is one of the high‐risk genetic factors for HPV‐associated malignancies among the Chinese population. Cancer 2002;95:2571–6. © 2002 American Cancer Society.
DOI 10.1002/cncr.11008
The current study showed that the p53 codon 72 Arg homozygous genotype is one of the high‐risk genetic factors for human papillomavirus‐associated malignancies among the Chinese population.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/cncr.11008</identifier><identifier>PMID: 12467072</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>allele specific polymerase chain reaction analysis ; Alleles ; Biological and medical sciences ; Breast Neoplasms - ethnology ; Breast Neoplasms - genetics ; Breast Neoplasms - virology ; Case-Control Studies ; China - epidemiology ; Codon ; DNA Primers - chemistry ; Esophageal Neoplasms - ethnology ; Esophageal Neoplasms - genetics ; Esophageal Neoplasms - virology ; Esophagus ; Female ; Female genital diseases ; Gastroenterology. Liver. Pancreas. Abdomen ; Genotype ; Gynecology. Andrology. Obstetrics ; Homozygote ; human papillomavirus ; Humans ; Medical sciences ; p53 ; Papillomaviridae - pathogenicity ; Polymerase Chain Reaction ; polymorphism ; Polymorphism, Genetic ; Risk Factors ; Tropical medicine ; Tumor Suppressor Protein p53 - genetics ; Tumors ; Uterine Cervical Neoplasms - ethnology ; Uterine Cervical Neoplasms - genetics ; Uterine Cervical Neoplasms - virology</subject><ispartof>Cancer, 2002-12, Vol.95 (12), p.2571-2576</ispartof><rights>Copyright © 2002 American Cancer Society</rights><rights>2003 INIST-CNRS</rights><rights>Copyright 2002 American Cancer Society.DOI 10.1002/cncr.11008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3558-5a63f9476a6a53d200b833d173bccea74835165e88ff5e7e21074220209e970a3</citedby><cites>FETCH-LOGICAL-c3558-5a63f9476a6a53d200b833d173bccea74835165e88ff5e7e21074220209e970a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcncr.11008$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcncr.11008$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27903,27904,45553,45554,46387,46811</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14427370$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12467072$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Tao</creatorcontrib><creatorcontrib>Lu, Zhe‐Ming</creatorcontrib><creatorcontrib>Guo, Mei</creatorcontrib><creatorcontrib>Wu, Qin‐Jiao</creatorcontrib><creatorcontrib>Chen, Ke‐Neng</creatorcontrib><creatorcontrib>Xing, Hai‐Ping</creatorcontrib><creatorcontrib>Mei, Qiang</creatorcontrib><creatorcontrib>Ke, Yang</creatorcontrib><title>p53 codon 72 polymorphism (C/G) and the risk of human papillomavirus‐associated carcinomas in China</title><title>Cancer</title><addtitle>Cancer</addtitle><description>BACKGROUND
Human papillomavirus (HPV) plays an important role in the development of carcinomas at various body sites. It was found previously that the p53 codon 72 polymorphism (C/G) is a high‐risk factor for the development HPV‐associated cervical carcinoma. However, it still was considered controversial in several studies of cervical and esophageal carcinoma.
METHODS
In the current study, the authors used an allele specific polymerase chain reaction (PCR) method to analyze correlation between the p53 codon 72 (C/G) polymorphism and HPV‐associated, noncancerous esophageal epithelium as well as esophageal, ovarian, and breast carcinoma in the Chinese population. Esophageal balloon cytology examination samples were obtained from high‐incidence and low‐incidence populations for esophageal carcinoma in Anyang (Henan Province).
RESULTS
Thirty‐six of 48 esophageal balloon samples from the high‐incidence population were HPV positive, and 13 of 33 esophageal balloon samples from the low‐incidence population were HPV positive. Thirty‐nine of 62 esophageal carcinoma samples from Anyang Tumor Hospital were HPV positive. Twenty‐six of 39 ovarian carcinoma samples from the Second Affiliated Hospital of Inner Mongolia Medical College were HPV positive. Nineteen of 82 breast carcinoma samples from Beijing Cancer Hospital were HPV positive. It is noteworthy that the distribution of the p53 codon 72 Arg homozygous genotype in HPV positive samples of esophageal epithelium, ovarian carcinoma, and breast carcinoma was significantly higher compared with HPV negative tumor samples. (P < 0.05).
CONCLUSIONS
The current results suggest that the p53 codon 72 Arg homozygous genotype is one of the high‐risk genetic factors for HPV‐associated malignancies among the Chinese population. Cancer 2002;95:2571–6. © 2002 American Cancer Society.
DOI 10.1002/cncr.11008
The current study showed that the p53 codon 72 Arg homozygous genotype is one of the high‐risk genetic factors for human papillomavirus‐associated malignancies among the Chinese population.</description><subject>allele specific polymerase chain reaction analysis</subject><subject>Alleles</subject><subject>Biological and medical sciences</subject><subject>Breast Neoplasms - ethnology</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - virology</subject><subject>Case-Control Studies</subject><subject>China - epidemiology</subject><subject>Codon</subject><subject>DNA Primers - chemistry</subject><subject>Esophageal Neoplasms - ethnology</subject><subject>Esophageal Neoplasms - genetics</subject><subject>Esophageal Neoplasms - virology</subject><subject>Esophagus</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Genotype</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Homozygote</subject><subject>human papillomavirus</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>p53</subject><subject>Papillomaviridae - pathogenicity</subject><subject>Polymerase Chain Reaction</subject><subject>polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Risk Factors</subject><subject>Tropical medicine</subject><subject>Tumor Suppressor Protein p53 - genetics</subject><subject>Tumors</subject><subject>Uterine Cervical Neoplasms - ethnology</subject><subject>Uterine Cervical Neoplasms - genetics</subject><subject>Uterine Cervical Neoplasms - virology</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90M1KAzEQB_AgitbqxQeQXBQVqvncbI-y-AWiIArelmk2S6O7yZp0ld58BJ_RJzG1BW-ekkl-zAx_hPYoOaWEsDPtdDil6ZqvoQElYzUiVLB1NCDpaSQFf95C2zG-pFIxyTfRFmUiU6kYINNJjrWvvMOK4c4389aHbmpji4-Ks6tjDK7Cs6nBwcZX7Gs87VtwuIPONo1v4d2GPn5_fkGMXluYmQprCNq69BexdbiYWgc7aKOGJprd1TlET5cXj8X16Pb-6qY4vx1pLmVaFTJej4XKIAPJK0bIJOe8oopPtDagRM4lzaTJ87qWRhlGiRKMEUbGZqwI8CE6XPbtgn_rTZyVrY3aNA044_tYKrbwXCR4soQ6-BiDqcsu2BbCvKSkXIRaLkItf0NNeH_VtZ-0pvqjqxQTOFgBiBqaOoDTNv45IZjiiiRHl-7DNmb-z8iyuCselsN_AJtbjeM</recordid><startdate>20021215</startdate><enddate>20021215</enddate><creator>Li, Tao</creator><creator>Lu, Zhe‐Ming</creator><creator>Guo, Mei</creator><creator>Wu, Qin‐Jiao</creator><creator>Chen, Ke‐Neng</creator><creator>Xing, Hai‐Ping</creator><creator>Mei, Qiang</creator><creator>Ke, Yang</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021215</creationdate><title>p53 codon 72 polymorphism (C/G) and the risk of human papillomavirus‐associated carcinomas in China</title><author>Li, Tao ; Lu, Zhe‐Ming ; Guo, Mei ; Wu, Qin‐Jiao ; Chen, Ke‐Neng ; Xing, Hai‐Ping ; Mei, Qiang ; Ke, Yang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3558-5a63f9476a6a53d200b833d173bccea74835165e88ff5e7e21074220209e970a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>allele specific polymerase chain reaction analysis</topic><topic>Alleles</topic><topic>Biological and medical sciences</topic><topic>Breast Neoplasms - ethnology</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - virology</topic><topic>Case-Control Studies</topic><topic>China - epidemiology</topic><topic>Codon</topic><topic>DNA Primers - chemistry</topic><topic>Esophageal Neoplasms - ethnology</topic><topic>Esophageal Neoplasms - genetics</topic><topic>Esophageal Neoplasms - virology</topic><topic>Esophagus</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Genotype</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Homozygote</topic><topic>human papillomavirus</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>p53</topic><topic>Papillomaviridae - pathogenicity</topic><topic>Polymerase Chain Reaction</topic><topic>polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Risk Factors</topic><topic>Tropical medicine</topic><topic>Tumor Suppressor Protein p53 - genetics</topic><topic>Tumors</topic><topic>Uterine Cervical Neoplasms - ethnology</topic><topic>Uterine Cervical Neoplasms - genetics</topic><topic>Uterine Cervical Neoplasms - virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Tao</creatorcontrib><creatorcontrib>Lu, Zhe‐Ming</creatorcontrib><creatorcontrib>Guo, Mei</creatorcontrib><creatorcontrib>Wu, Qin‐Jiao</creatorcontrib><creatorcontrib>Chen, Ke‐Neng</creatorcontrib><creatorcontrib>Xing, Hai‐Ping</creatorcontrib><creatorcontrib>Mei, Qiang</creatorcontrib><creatorcontrib>Ke, Yang</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Tao</au><au>Lu, Zhe‐Ming</au><au>Guo, Mei</au><au>Wu, Qin‐Jiao</au><au>Chen, Ke‐Neng</au><au>Xing, Hai‐Ping</au><au>Mei, Qiang</au><au>Ke, Yang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>p53 codon 72 polymorphism (C/G) and the risk of human papillomavirus‐associated carcinomas in China</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>2002-12-15</date><risdate>2002</risdate><volume>95</volume><issue>12</issue><spage>2571</spage><epage>2576</epage><pages>2571-2576</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>BACKGROUND
Human papillomavirus (HPV) plays an important role in the development of carcinomas at various body sites. It was found previously that the p53 codon 72 polymorphism (C/G) is a high‐risk factor for the development HPV‐associated cervical carcinoma. However, it still was considered controversial in several studies of cervical and esophageal carcinoma.
METHODS
In the current study, the authors used an allele specific polymerase chain reaction (PCR) method to analyze correlation between the p53 codon 72 (C/G) polymorphism and HPV‐associated, noncancerous esophageal epithelium as well as esophageal, ovarian, and breast carcinoma in the Chinese population. Esophageal balloon cytology examination samples were obtained from high‐incidence and low‐incidence populations for esophageal carcinoma in Anyang (Henan Province).
RESULTS
Thirty‐six of 48 esophageal balloon samples from the high‐incidence population were HPV positive, and 13 of 33 esophageal balloon samples from the low‐incidence population were HPV positive. Thirty‐nine of 62 esophageal carcinoma samples from Anyang Tumor Hospital were HPV positive. Twenty‐six of 39 ovarian carcinoma samples from the Second Affiliated Hospital of Inner Mongolia Medical College were HPV positive. Nineteen of 82 breast carcinoma samples from Beijing Cancer Hospital were HPV positive. It is noteworthy that the distribution of the p53 codon 72 Arg homozygous genotype in HPV positive samples of esophageal epithelium, ovarian carcinoma, and breast carcinoma was significantly higher compared with HPV negative tumor samples. (P < 0.05).
CONCLUSIONS
The current results suggest that the p53 codon 72 Arg homozygous genotype is one of the high‐risk genetic factors for HPV‐associated malignancies among the Chinese population. Cancer 2002;95:2571–6. © 2002 American Cancer Society.
DOI 10.1002/cncr.11008
The current study showed that the p53 codon 72 Arg homozygous genotype is one of the high‐risk genetic factors for human papillomavirus‐associated malignancies among the Chinese population.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>12467072</pmid><doi>10.1002/cncr.11008</doi><tpages>6</tpages></addata></record> |
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| subjects | allele specific polymerase chain reaction analysis Alleles Biological and medical sciences Breast Neoplasms - ethnology Breast Neoplasms - genetics Breast Neoplasms - virology Case-Control Studies China - epidemiology Codon DNA Primers - chemistry Esophageal Neoplasms - ethnology Esophageal Neoplasms - genetics Esophageal Neoplasms - virology Esophagus Female Female genital diseases Gastroenterology. Liver. Pancreas. Abdomen Genotype Gynecology. Andrology. Obstetrics Homozygote human papillomavirus Humans Medical sciences p53 Papillomaviridae - pathogenicity Polymerase Chain Reaction polymorphism Polymorphism, Genetic Risk Factors Tropical medicine Tumor Suppressor Protein p53 - genetics Tumors Uterine Cervical Neoplasms - ethnology Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - virology |
| title | p53 codon 72 polymorphism (C/G) and the risk of human papillomavirus‐associated carcinomas in China |
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