Amplification of ETS2 oncogene in acute nonlymphoblastic leukemia with t(6;21;18)

Cytogenetic and molecular studies in a case of acute nonlymphoblastic leukemia (ANLL) are reported in this paper. Bone marrow blasts carried a hypodiploid karyotype with a complex t(6;18;21)(6qter→6p21::21q22→21qter;18qter→18p11::6p22→6pter;21pter→21q22::6p21→6p22::18p11→18pter) and other numerical...

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Veröffentlicht in:	Cancer genetics and cytogenetics 1992, Vol.58 (1), p.71-75
Hauptverfasser:	Santoro, A., Maggio, A., Carbone, P., Mirto, S., Caronia, F., Acuto, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biological and medical sciences Blotting, Northern Blotting, Southern Chromosome Aberrations Chromosomes, Human, Pair 18 Chromosomes, Human, Pair 21 Chromosomes, Human, Pair 6 DNA-Binding Proteins Gene Amplification - genetics Hematologic and hematopoietic diseases Humans Leukemia, Myeloid, Acute - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Protein-Tyrosine Kinases - genetics Proto-Oncogene Protein c-ets-2 Proto-Oncogene Proteins - genetics Repressor Proteins Trans-Activators Transcription Factors Translocation, Genetic
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