Increased urinary leukotriene excretion in patients with cardiac ischemia : in vivo evidence for 5-lipoxygenase activation

Experimental cardiac ischemia in some animal models results in the activation of the enzyme 5-lipoxygenase and the subsequent production of leukotrienes, potent proinflammatory lipid mediators, by the affected myocardium. Furthermore, prototype antileukotriene drugs can show some beneficial effects...

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