Effects of l-threo-DOPS, a noradrenaline precursor, on the long-term potentiation in the rat hippocampal mossy fiber-CA3 region
The effects of l-threo-3,4-dihydroxyphenylserine ( l-threo-DOPS), a synthetic precursor of norepinephrine (NE), on the long-term potentiation (LTP) in the hippocampal mossy fiber-CA3 system was examined in urethane-anesthetized rats, the objective being to determine whether or not this drug acts as...
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| Veröffentlicht in: | Brain research 1991-12, Vol.567 (2), p.267-273 |
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| creator | Sakai, Norio Sasa, Masashi Ishihara, Kumatoshi Komure, Osamu Tanaka, Chikako Takaori, Shuji |
| description | The effects of
l-threo-3,4-dihydroxyphenylserine (
l-threo-DOPS), a synthetic precursor of norepinephrine (NE), on the long-term potentiation (LTP) in the hippocampal mossy fiber-CA3 system was examined in urethane-anesthetized rats, the objective being to determine whether or not this drug acts as NE on the LTP.
l-threo-DOPS may be effective for treating some type of mental disorders, including dementia. The LTP, induced in CA3 by tetanic stimulation (100 Hz for 1 s) applied to the mossy fiber persisted for more than 4 h. When
l-threo-DOPS (50 and 150 μg) was injected into the lateral ventricle 30 min prior to the tetanic stimulation, there were no significant alterations in the LTP. However, in animals treated with reserpine (5 mg/kg i.p.) 24 h before the experiment. LTP was not induced with tetanic stimulation alone yet was obtained when tetanic stimulation was preceded by
l-threo-DOPS (50 and 150 μg) applied to the ventricle. The LTP obtained by
l-threo-DOPS in the reserpine-treated animal was inhibited by pretreatment with benserazide and was completely blocked by the simultaneous administration of sotalol. These results suggest that NE converted from
l-threo-DOPS plays an important role in inducing LTP in the mossy fiber-CA3 system in the animals deficient in catecholamines. |
| doi_str_mv | 10.1016/0006-8993(91)90805-6 |
| format | Article |
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l-threo-3,4-dihydroxyphenylserine (
l-threo-DOPS), a synthetic precursor of norepinephrine (NE), on the long-term potentiation (LTP) in the hippocampal mossy fiber-CA3 system was examined in urethane-anesthetized rats, the objective being to determine whether or not this drug acts as NE on the LTP.
l-threo-DOPS may be effective for treating some type of mental disorders, including dementia. The LTP, induced in CA3 by tetanic stimulation (100 Hz for 1 s) applied to the mossy fiber persisted for more than 4 h. When
l-threo-DOPS (50 and 150 μg) was injected into the lateral ventricle 30 min prior to the tetanic stimulation, there were no significant alterations in the LTP. However, in animals treated with reserpine (5 mg/kg i.p.) 24 h before the experiment. LTP was not induced with tetanic stimulation alone yet was obtained when tetanic stimulation was preceded by
l-threo-DOPS (50 and 150 μg) applied to the ventricle. The LTP obtained by
l-threo-DOPS in the reserpine-treated animal was inhibited by pretreatment with benserazide and was completely blocked by the simultaneous administration of sotalol. These results suggest that NE converted from
l-threo-DOPS plays an important role in inducing LTP in the mossy fiber-CA3 system in the animals deficient in catecholamines.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(91)90805-6</identifier><identifier>PMID: 1817730</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Anesthesia ; Animals ; Biological and medical sciences ; Central nervous system ; Droxidopa - antagonists & inhibitors ; Droxidopa - pharmacology ; Electric Stimulation ; Electrophysiology ; Evoked Potentials - drug effects ; Fundamental and applied biological sciences. Psychology ; Hippocampus ; Hippocampus - cytology ; Hippocampus - drug effects ; Hippocampus - physiology ; Injections, Intraventricular ; l-threo-3,4-Dihydroxyphenylserine ; Long-term potentiation ; Male ; Noradrenaline ; Norepinephrine - physiology ; Pyramidal Tracts - cytology ; Pyramidal Tracts - drug effects ; Rats ; Rats, Inbred Strains ; Reserpine - antagonists & inhibitors ; Reserpine - pharmacology ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research, 1991-12, Vol.567 (2), p.267-273</ispartof><rights>1991 Elsevier Science Publishers B.V.</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-4573461ef91cf61405f77fd471dc800c6ebe85c3284b83a9845277cb4fa978af3</citedby><cites>FETCH-LOGICAL-c417t-4573461ef91cf61405f77fd471dc800c6ebe85c3284b83a9845277cb4fa978af3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0006899391908056$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5095062$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1817730$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sakai, Norio</creatorcontrib><creatorcontrib>Sasa, Masashi</creatorcontrib><creatorcontrib>Ishihara, Kumatoshi</creatorcontrib><creatorcontrib>Komure, Osamu</creatorcontrib><creatorcontrib>Tanaka, Chikako</creatorcontrib><creatorcontrib>Takaori, Shuji</creatorcontrib><title>Effects of l-threo-DOPS, a noradrenaline precursor, on the long-term potentiation in the rat hippocampal mossy fiber-CA3 region</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>The effects of
l-threo-3,4-dihydroxyphenylserine (
l-threo-DOPS), a synthetic precursor of norepinephrine (NE), on the long-term potentiation (LTP) in the hippocampal mossy fiber-CA3 system was examined in urethane-anesthetized rats, the objective being to determine whether or not this drug acts as NE on the LTP.
l-threo-DOPS may be effective for treating some type of mental disorders, including dementia. The LTP, induced in CA3 by tetanic stimulation (100 Hz for 1 s) applied to the mossy fiber persisted for more than 4 h. When
l-threo-DOPS (50 and 150 μg) was injected into the lateral ventricle 30 min prior to the tetanic stimulation, there were no significant alterations in the LTP. However, in animals treated with reserpine (5 mg/kg i.p.) 24 h before the experiment. LTP was not induced with tetanic stimulation alone yet was obtained when tetanic stimulation was preceded by
l-threo-DOPS (50 and 150 μg) applied to the ventricle. The LTP obtained by
l-threo-DOPS in the reserpine-treated animal was inhibited by pretreatment with benserazide and was completely blocked by the simultaneous administration of sotalol. These results suggest that NE converted from
l-threo-DOPS plays an important role in inducing LTP in the mossy fiber-CA3 system in the animals deficient in catecholamines.</description><subject>Anesthesia</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Droxidopa - antagonists & inhibitors</subject><subject>Droxidopa - pharmacology</subject><subject>Electric Stimulation</subject><subject>Electrophysiology</subject><subject>Evoked Potentials - drug effects</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hippocampus</subject><subject>Hippocampus - cytology</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - physiology</subject><subject>Injections, Intraventricular</subject><subject>l-threo-3,4-Dihydroxyphenylserine</subject><subject>Long-term potentiation</subject><subject>Male</subject><subject>Noradrenaline</subject><subject>Norepinephrine - physiology</subject><subject>Pyramidal Tracts - cytology</subject><subject>Pyramidal Tracts - drug effects</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Reserpine - antagonists & inhibitors</subject><subject>Reserpine - pharmacology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rFTEUhoMo9bb6DxSyEFFoNJlkJslGKLf1AwoV1HXIZE56IzOTMckVuvKvm-tc6k5XIbzPOSTPi9AzRt8wyrq3lNKOKK35K81ea6poS7oHaMOUbEjXCPoQbe6Rx-g05-_1yrmmJ-iEKSYlpxv068p7cCXj6PFIyi5BJJc3n7-cY4vnmOyQYLZjmAEvCdw-5ZjOcZxx2QEe43xLCqQJL7HAXIItoUZhTZMteBeWJTo7LXbEU8z5DvvQQyLbC44T3Fb6CXrk7Zjh6fE8Q9_eX33dfiTXNx8-bS-uiRNMFiJayUXHwGvmfMcEbb2UfhCSDU5R6jroQbWON0r0ilutRNtI6XrhrZbKen6GXq57lxR_7CEXM4XsYBztDHGfjWwkr57Uf0HWMV6tygqKFXSp_iyBN0sKk013hlFzKMgc7JuDfaOZ-VOQ6erY8-P-fT_B8HdobaTmL465zc6OPtnZhXyPtVS3tGsq9m7FoEr7GSCZ7ALMDoZQeypmiOHf7_gNxFGsAw</recordid><startdate>19911220</startdate><enddate>19911220</enddate><creator>Sakai, Norio</creator><creator>Sasa, Masashi</creator><creator>Ishihara, Kumatoshi</creator><creator>Komure, Osamu</creator><creator>Tanaka, Chikako</creator><creator>Takaori, Shuji</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19911220</creationdate><title>Effects of l-threo-DOPS, a noradrenaline precursor, on the long-term potentiation in the rat hippocampal mossy fiber-CA3 region</title><author>Sakai, Norio ; Sasa, Masashi ; Ishihara, Kumatoshi ; Komure, Osamu ; Tanaka, Chikako ; Takaori, Shuji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-4573461ef91cf61405f77fd471dc800c6ebe85c3284b83a9845277cb4fa978af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Anesthesia</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Droxidopa - antagonists & inhibitors</topic><topic>Droxidopa - pharmacology</topic><topic>Electric Stimulation</topic><topic>Electrophysiology</topic><topic>Evoked Potentials - drug effects</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hippocampus</topic><topic>Hippocampus - cytology</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - physiology</topic><topic>Injections, Intraventricular</topic><topic>l-threo-3,4-Dihydroxyphenylserine</topic><topic>Long-term potentiation</topic><topic>Male</topic><topic>Noradrenaline</topic><topic>Norepinephrine - physiology</topic><topic>Pyramidal Tracts - cytology</topic><topic>Pyramidal Tracts - drug effects</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Reserpine - antagonists & inhibitors</topic><topic>Reserpine - pharmacology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sakai, Norio</creatorcontrib><creatorcontrib>Sasa, Masashi</creatorcontrib><creatorcontrib>Ishihara, Kumatoshi</creatorcontrib><creatorcontrib>Komure, Osamu</creatorcontrib><creatorcontrib>Tanaka, Chikako</creatorcontrib><creatorcontrib>Takaori, Shuji</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sakai, Norio</au><au>Sasa, Masashi</au><au>Ishihara, Kumatoshi</au><au>Komure, Osamu</au><au>Tanaka, Chikako</au><au>Takaori, Shuji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of l-threo-DOPS, a noradrenaline precursor, on the long-term potentiation in the rat hippocampal mossy fiber-CA3 region</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1991-12-20</date><risdate>1991</risdate><volume>567</volume><issue>2</issue><spage>267</spage><epage>273</epage><pages>267-273</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>The effects of
l-threo-3,4-dihydroxyphenylserine (
l-threo-DOPS), a synthetic precursor of norepinephrine (NE), on the long-term potentiation (LTP) in the hippocampal mossy fiber-CA3 system was examined in urethane-anesthetized rats, the objective being to determine whether or not this drug acts as NE on the LTP.
l-threo-DOPS may be effective for treating some type of mental disorders, including dementia. The LTP, induced in CA3 by tetanic stimulation (100 Hz for 1 s) applied to the mossy fiber persisted for more than 4 h. When
l-threo-DOPS (50 and 150 μg) was injected into the lateral ventricle 30 min prior to the tetanic stimulation, there were no significant alterations in the LTP. However, in animals treated with reserpine (5 mg/kg i.p.) 24 h before the experiment. LTP was not induced with tetanic stimulation alone yet was obtained when tetanic stimulation was preceded by
l-threo-DOPS (50 and 150 μg) applied to the ventricle. The LTP obtained by
l-threo-DOPS in the reserpine-treated animal was inhibited by pretreatment with benserazide and was completely blocked by the simultaneous administration of sotalol. These results suggest that NE converted from
l-threo-DOPS plays an important role in inducing LTP in the mossy fiber-CA3 system in the animals deficient in catecholamines.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>1817730</pmid><doi>10.1016/0006-8993(91)90805-6</doi><tpages>7</tpages></addata></record> |
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| ispartof | Brain research, 1991-12, Vol.567 (2), p.267-273 |
| issn | 0006-8993 1872-6240 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Anesthesia Animals Biological and medical sciences Central nervous system Droxidopa - antagonists & inhibitors Droxidopa - pharmacology Electric Stimulation Electrophysiology Evoked Potentials - drug effects Fundamental and applied biological sciences. Psychology Hippocampus Hippocampus - cytology Hippocampus - drug effects Hippocampus - physiology Injections, Intraventricular l-threo-3,4-Dihydroxyphenylserine Long-term potentiation Male Noradrenaline Norepinephrine - physiology Pyramidal Tracts - cytology Pyramidal Tracts - drug effects Rats Rats, Inbred Strains Reserpine - antagonists & inhibitors Reserpine - pharmacology Vertebrates: nervous system and sense organs |
| title | Effects of l-threo-DOPS, a noradrenaline precursor, on the long-term potentiation in the rat hippocampal mossy fiber-CA3 region |
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