Further case of paroxysmal exercise-induced dystonia and some insights into pathogenesis

Cerebrospinal fluid (CSF) analysis of pterin and monamine metabolites was performed before and after an attack in a patient with paroxysmal exercise‐induced dystonia. A twofold increase in CSF homovanillic acid and 5‐hydroxyindoleacetic acid after an attack was measured. This finding lends support t...

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Veröffentlicht in:Movement disorders 2002-11, Vol.17 (6), p.1386-1387
Hauptverfasser: Barnett, Michael H., Jarman, Paul R., Heales, Simon J.R., Bhatia, Kailash P.
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container_title Movement disorders
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creator Barnett, Michael H.
Jarman, Paul R.
Heales, Simon J.R.
Bhatia, Kailash P.
description Cerebrospinal fluid (CSF) analysis of pterin and monamine metabolites was performed before and after an attack in a patient with paroxysmal exercise‐induced dystonia. A twofold increase in CSF homovanillic acid and 5‐hydroxyindoleacetic acid after an attack was measured. This finding lends support to the hypothesis that increased dopaminergic transmission contributes to the clinical features of the hyperkinetic movement disorders. © 2002 Movement Disorder Society
doi_str_mv 10.1002/mds.10291
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subjects Adult
cerebrospinal fluid
dopamine
Dopamine - physiology
Dystonia - diagnosis
Dystonia - physiopathology
Exercise - physiology
homovanillic acid
Homovanillic Acid - cerebrospinal fluid
Humans
hydroxyindoleacetic acid
Hydroxyindoleacetic Acid - cerebrospinal fluid
Male
Neurologic Examination
paroxysmal exercise-induced dystonia
Synaptic Transmission - physiology
title Further case of paroxysmal exercise-induced dystonia and some insights into pathogenesis
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