Glandular-like morphogenesis of the human submandibular tumor cell line A253 on basement membrane components

We have studied the interaction of a human tumor cell line, A253, derived from a submandibular gland carcinoma with a differentiation promoting reconstituted basement membrane extract, Matrigel. When cultured on plastic, these cells maintain a flat, cobblestone, epithelial morphology. On Matrigel, A...

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Veröffentlicht in:	Experimental cell research 1992-02, Vol.198 (2), p.343-351
Hauptverfasser:	Kibeey, Maura C., Royce, Leah S., Dym, Martin, Baum, Bruce J., Kleinman, Hynda K.
Format:	Artikel
Sprache:	eng
Schlagworte:	A253 cells basement membranes Biological and medical sciences Blotting, Western Cell Adhesion - physiology Cell Differentiation - physiology Cell differentiation, maturation, development, hematopoiesis Cell physiology Collagen - metabolism Drug Combinations Fundamental and applied biological sciences. Psychology Humans induction laminin Laminin - metabolism man Microscopy, Electron Molecular and cellular biology Morphogenesis Proteoglycans - metabolism Receptors, Immunologic - analysis Receptors, Laminin submandibular gland Submandibular Gland Neoplasms - pathology Tumor Cells, Cultured - cytology tumours
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